Talin
"Talin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 235-kDa cytoplasmic protein that is also found in platelets. It has been localized to regions of cell-substrate adhesion. It binds to INTEGRINS; VINCULIN; and ACTINS and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.
Descriptor ID |
D016608
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MeSH Number(s) |
D12.776.220.985
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Concept/Terms |
Talin- Talin
- Band 2 Protein
- Protein, Band 2
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Below are MeSH descriptors whose meaning is more general than "Talin".
Below are MeSH descriptors whose meaning is more specific than "Talin".
This graph shows the total number of publications written about "Talin" by people in this website by year, and whether "Talin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2004 | 1 | 0 | 1 | 2006 | 2 | 0 | 2 | 2012 | 1 | 1 | 2 | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Talin" by people in Profiles.
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Getz TM, Piatt R, Petrich BG, Monroe D, Mackman N, Bergmeier W. Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition. J Thromb Haemost. 2015 Mar; 13(3):417-25.
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Rajshankar D, Downey GP, McCulloch CA. IL-1? enhances cell adhesion to degraded fibronectin. FASEB J. 2012 Nov; 26(11):4429-44.
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Ahmad HA, Lu L, Ye S, Schwartz GG, Greyson CR. Calpain inhibition preserves talin and attenuates right heart failure in acute pulmonary hypertension. Am J Respir Cell Mol Biol. 2012 Sep; 47(3):379-86.
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Simonson WT, Franco SJ, Huttenlocher A. Talin1 regulates TCR-mediated LFA-1 function. J Immunol. 2006 Dec 01; 177(11):7707-14.
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Franco SJ, Senetar MA, Simonson WT, Huttenlocher A, McCann RO. The conserved C-terminal I/LWEQ module targets Talin1 to focal adhesions. Cell Motil Cytoskeleton. 2006 Sep; 63(9):563-81.
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Franco SJ, Rodgers MA, Perrin BJ, Han J, Bennin DA, Critchley DR, Huttenlocher A. Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol. 2004 Oct; 6(10):977-83.
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