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Xuedong Liu

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry
Phone303/735-6161

    Collapse Research 
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    R21GM135668     (GOODWIN, ANDREW P)Jan 1, 2020 - Dec 31, 2021
    NIH
    Affinity-Mediated Covalent Conjugation: A Method for Direct Modification of Specific Receptors on Cell Membranes
    Role: Co-Principal Investigator
    S10OD025072     (LIU, XUEDONG)Jul 15, 2018 - Jul 14, 2019
    NIH
    Opera Phenix High Throughput and High Content Confocal Microscope
    Role: Principal Investigator
    S10OD021601     (LIU, XUEDONG)Apr 1, 2016 - Mar 31, 2017
    NIH
    FACSAria Fusion Cell Sorter
    Role: Principal Investigator
    R01AR068254     (LIU, XUEDONG)Sep 14, 2015 - Aug 31, 2021
    NIH
    Quantitative Analysis of Mechanochemical Signaling in Wound Response
    Role: Principal Investigator
    R03NS093607     (LIU, XUEDONG)Aug 15, 2015 - Jul 31, 2018
    NIH
    Development of Analog Sensitive PINK1 Animal Model and iPS Cells
    Role: Principal Investigator
    R01GM113141     (LIU, XUEDONG)Aug 1, 2015 - Jul 31, 2019
    NIH
    High Throughput Screening to Discover Chemical Probes and Pharmacological Agents for Modulating Parkin Activity
    Role: Principal Investigator
    S10RR026680     (LIU, XUEDONG)Sep 26, 2011 - Sep 25, 2013
    NIH
    ImageXpress Micro Cellular Imagining and Analysis System
    Role: Principal Investigator
    F33GM093670     (LIU, XUEDONG)May 21, 2010 - Nov 20, 2010
    NIH
    A Systems Biology Analysis of Spindle Checkpoint Signaling
    Role: Principal Investigator
    R01GM083172     (LIU, XUEDONG)Apr 1, 2008 - Mar 31, 2013
    NIH
    Quantitative Analysis of TGF-b/Smad Signaling Dynamics
    Role: Principal Investigator
    R01CA107098     (LIU, XUEDONG)Apr 1, 2004 - Apr 30, 2014
    NIH
    Mechanisms of p27Kipl Proteolysis in Cancer Cells
    Role: Principal Investigator
    R01CA095527     (LIU, XUEDONG)Apr 1, 2002 - Mar 31, 2008
    NIH
    Regulation of Ski-SnoN by Cell Cycle and TGF-beta
    Role: Principal Investigator
    F32CA067460     (LIU, XUEDONG)Nov 11, 1995
    NIH
    TGF B SIGNAL TRANSDUCTION PATHWAY(S)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Guard SE, Chapnick DA, Poss ZC, Ebmeier CC, Jacobsen J, Nemkov T, Ball KA, Webb KJ, Simpson HL, Coleman S, Bunker E, Ramirez A, Reisz JA, Sievers R, Stowell MHB, D'Alessandro A, Liu X, Old WM. Multiomic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines. Mol Cell Proteomics. 2022 Oct; 21(10):100262. PMID: 35753663.
      View in: PubMed
    2. Xu Q, Zhang X, Sanchez GJ, Ramirez AT, Liu X. Cell type-specific intercellular gene transfer in mammalian cells via transient cell entrapment. Cell Discov. 2022 Mar 01; 8(1):20. PMID: 35228545.
      View in: PubMed
    3. Liu Z, Ramirez A, Liu X. Live Cell Imaging of Spatiotemporal Ca2+ Fluctuation Responses to Anticancer Drugs. Methods Mol Biol. 2022; 2488:227-236. PMID: 35347692.
      View in: PubMed
    4. Wheeler GE, Purkayastha A, Bunker EN, Bortz DM, Liu X. Protocol for Analysis and Consolidation of TrackMate Outputs for Measuring Two-Dimensional Cell Motility using Nuclear Tracking. J Vis Exp. 2021 12 18; (178). PMID: 34978296.
      View in: PubMed
    5. Ramirez A, Old W, Selwood DL, Liu X. Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles. Eur J Cell Biol. 2022 Jan; 101(1):151185. PMID: 34915361.
      View in: PubMed
    6. Roy S, Curry SD, Bibbey MG, Chapnick DA, Liu X, Goodwin AP, Cha JN. Effect of covalent photoconjugation of affibodies to epidermal growth factor receptor (EGFR) on cellular quiescence. Biotechnol Bioeng. 2022 01; 119(1):187-198. PMID: 34676884.
      View in: PubMed
    7. Clarke DC, Brown ML, Erickson RA, Shi Y, Liu X. Correction for Clarke et al., "Transforming Growth Factor ? Depletion Is the Primary Determinant of Smad Signaling Kinetics". Mol Cell Biol. 2021 Jul 23; 41(8):e0025521. PMID: 34296951.
      View in: PubMed
    8. Bunker EN, Wheeler GE, Chapnick DA, Liu X. Suppression of a-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-a autocrine/paracrine signaling. Mol Biol Cell. 2021 02 15; 32(4):348-361. PMID: 33378218.
      View in: PubMed
    9. Zhang X, Xu Q, Zi Z, Liu Z, Wan C, Crisman L, Shen J, Liu X. Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications. Dev Cell. 2020 12 21; 55(6):784-801.e9. PMID: 33296682.
      View in: PubMed
    10. Zhang C, Wang R, Liu Z, Bunker E, Lee S, Giuntini M, Chapnick D, Liu X. The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1's association with the mitochondrial protein TOM20. J Biol Chem. 2019 05 03; 294(18):7472-7487. PMID: 30885942.
      View in: PubMed
    11. Chapnick DA, Bunker E, Liu X, Old WM. Temporal Metabolite, Ion, and Enzyme Activity Profiling Using Fluorescence Microscopy and Genetically Encoded Biosensors. Methods Mol Biol. 2019; 1978:343-353. PMID: 31119673.
      View in: PubMed
    12. Grim JC, Brown TE, Aguado BA, Chapnick DA, Viert AL, Liu X, Anseth KS. A Reversible and Repeatable Thiol-Ene Bioconjugation for Dynamic Patterning of Signaling Proteins in Hydrogels. ACS Cent Sci. 2018 Jul 25; 4(7):909-916. PMID: 30062120.
      View in: PubMed
    13. Sanchez GJ, Richmond PA, Bunker EN, Karman SS, Azofeifa J, Garnett AT, Xu Q, Wheeler GE, Toomey CM, Zhang Q, Dowell RD, Liu X. Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers. Nucleic Acids Res. 2018 02 28; 46(4):1756-1776. PMID: 29240919.
      View in: PubMed
    14. Zhang C, Liu Z, Bunker E, Ramirez A, Lee S, Peng Y, Tan AC, Eckhardt SG, Chapnick DA, Liu X. Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response. J Biol Chem. 2017 09 08; 292(36):15105-15120. PMID: 28673964.
      View in: PubMed
    15. McQuate SE, Young AM, Silva-Herzog E, Bunker E, Hernandez M, de Chaumont F, Liu X, Detweiler CS, Palmer AE. Long-term live-cell imaging reveals new roles for Salmonella effector proteins SseG and SteA. Cell Microbiol. 2017 01; 19(1). PMID: 27376507.
      View in: PubMed
    16. Nardini JT, Chapnick DA, Liu X, Bortz DM. Modeling keratinocyte wound healing dynamics: Cell-cell adhesion promotes sustained collective migration. J Theor Biol. 2016 07 07; 400:103-17. PMID: 27105673.
      View in: PubMed
    17. Bennett CG, Riemondy K, Chapnick DA, Bunker E, Liu X, Kuersten S, Yi R. Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration. Nucleic Acids Res. 2016 05 05; 44(8):3788-800. PMID: 27034466.
      View in: PubMed
    18. Feng Z, Zi Z, Liu X. Measuring TGF-? Ligand Dynamics in Culture Medium. Methods Mol Biol. 2016; 1344:379-89. PMID: 26520139.
      View in: PubMed
    19. Davis EM, Kim J, Menasche BL, Sheppard J, Liu X, Tan AC, Shen J. Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins. Cell Rep. 2015 Jun 23; 11(11):1727-36. PMID: 26074080.
      View in: PubMed
    20. Chapnick DA, Bunker E, Liu X. A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation. Sci Signal. 2015 Feb 24; 8(365):rs1. PMID: 25714465.
      View in: PubMed
    21. Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, Shen J, Shen J, Zhou Z, Liu X. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell Res. 2015 Mar; 25(3):394-7. PMID: 25475060.
      View in: PubMed
    22. Lee S, Zhang C, Liu X. Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses. J Biol Chem. 2015 Jan 09; 290(2):904-17. PMID: 25404737.
      View in: PubMed
    23. Zhang C, Lee S, Peng Y, Bunker E, Giaime E, Shen J, Zhou Z, Liu X. PINK1 triggers autocatalytic activation of Parkin to specify cell fate decisions. Curr Biol. 2014 Aug 18; 24(16):1854-65. PMID: 25088558.
      View in: PubMed
    24. Chapnick DA, Liu X. Leader cell positioning drives wound-directed collective migration in TGF?-stimulated epithelial sheets. Mol Biol Cell. 2014 May; 25(10):1586-93. PMID: 24623725.
      View in: PubMed
    25. Chapnick DA, Jacobsen J, Liu X. The development of a novel high throughput computational tool for studying individual and collective cellular migration. PLoS One. 2013; 8(12):e82444. PMID: 24386097.
      View in: PubMed
    26. Ungermannova D, Lee J, Zhang G, Dallmann HG, McHenry CS, Liu X. High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1. J Biomol Screen. 2013 Sep; 18(8):910-20. PMID: 23589337.
      View in: PubMed
    27. Lee J, Sammond DW, Fiorini Z, Saludes JP, Resch MG, Hao B, Wang W, Yin H, Liu X. Computationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4). Chembiochem. 2013 Mar 04; 14(4):445-51. PMID: 23401343.
      View in: PubMed
    28. Liu X, Winey M. The MPS1 family of protein kinases. Annu Rev Biochem. 2012; 81:561-85. PMID: 22482908.
      View in: PubMed
    29. Ungermannova D, Parker SJ, Nasveschuk CG, Chapnick DA, Phillips AJ, Kuchta RD, Liu X. Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J Biomol Screen. 2012 Apr; 17(4):421-34. PMID: 22274912.
      View in: PubMed
    30. Ungermannova D, Parker SJ, Nasveschuk CG, Wang W, Quade B, Zhang G, Kuchta RD, Phillips AJ, Liu X. Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1). PLoS One. 2012; 7(1):e29208. PMID: 22279528.
      View in: PubMed
    31. Chapnick DA, Warner L, Bernet J, Rao T, Liu X. Partners in crime: the TGF? and MAPK pathways in cancer progression. Cell Biosci. 2011 Dec 28; 1:42. PMID: 22204556.
      View in: PubMed
    32. Zhang X, Yin Q, Ling Y, Zhang Y, Ma R, Ma Q, Cao C, Zhong H, Liu X, Xu Q. Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses. Cell Cycle. 2011 Aug 15; 10(16):2742-50. PMID: 21778823.
      View in: PubMed
    33. Sun T, Yang X, Wang W, Zhang X, Xu Q, Zhu S, Kuchta R, Chen G, Liu X. Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment. J Biol Chem. 2010 Dec 03; 285(49):38730-9. PMID: 20884615.
      View in: PubMed
    34. Chapnick DA, Liu X. Analysis of ligand-dependent nuclear accumulation of Smads in TGF-beta signaling. Methods Mol Biol. 2010; 647:95-111. PMID: 20694662.
      View in: PubMed
    35. Clarke DC, Liu X. Measuring the absolute abundance of the Smad transcription factors using quantitative immunoblotting. Methods Mol Biol. 2010; 647:357-76. PMID: 20694679.
      View in: PubMed
    36. Wang W, Yang Y, Gao Y, Xu Q, Wang F, Zhu S, Old W, Resing K, Ahn N, Lei M, Liu X. Structural and mechanistic insights into Mps1 kinase activation. J Cell Mol Med. 2009 Aug; 13(8B):1679-1694. PMID: 19120698.
      View in: PubMed
    37. Clarke DC, Brown ML, Erickson RA, Shi Y, Liu X. Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics. Mol Cell Biol. 2009 May; 29(9):2443-55. PMID: 19223462.
      View in: PubMed
    38. Erickson RA, Liu X. Association of v-ErbA with Smad4 disrupts TGF-beta signaling. Mol Biol Cell. 2009 Mar; 20(5):1509-19. PMID: 19144825.
      View in: PubMed
    39. Xu Q, Zhu S, Wang W, Zhang X, Old W, Ahn N, Liu X. Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. Mol Biol Cell. 2009 Jan; 20(1):10-20. PMID: 18923149.
      View in: PubMed
    40. Clarke DC, Liu X. Decoding the quantitative nature of TGF-beta/Smad signaling. Trends Cell Biol. 2008 Sep; 18(9):430-42. PMID: 18706811.
      View in: PubMed
    41. Nasveschuk CG, Ungermannova D, Liu X, Phillips AJ. A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships. Org Lett. 2008 Aug 21; 10(16):3595-8. PMID: 18616341.
      View in: PubMed
    42. Barthel KK, Liu X. A transcriptional enhancer from the coding region of ADAMTS5. PLoS One. 2008 May 14; 3(5):e2184. PMID: 18478108.
      View in: PubMed
    43. Zhang L, Ding L, Cheung TH, Dong MQ, Chen J, Sewell AK, Liu X, Yates JR, Han M. Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Mol Cell. 2007 Nov 30; 28(4):598-613. PMID: 18042455.
      View in: PubMed
    44. Cheung TH, Barthel KK, Kwan YL, Liu X. Identifying pattern-defined regulatory islands in mammalian genomes. Proc Natl Acad Sci U S A. 2007 Jun 12; 104(24):10116-21. PMID: 17535887.
      View in: PubMed
    45. Zhu S, Wang W, Clarke DC, Liu X. Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling. J Biol Chem. 2007 Jun 22; 282(25):18327-18338. PMID: 17452325.
      View in: PubMed
    46. Cheung TH, Kwan YL, Hamady M, Liu X. Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT. Genome Biol. 2006; 7(10):R97. PMID: 17064417.
      View in: PubMed
    47. Riquelme C, Barthel KK, Qin XF, Liu X. Ubc9 expression is essential for myotube formation in C2C12. Exp Cell Res. 2006 Jul 01; 312(11):2132-41. PMID: 16631162.
      View in: PubMed
    48. Riquelme C, Barthel KK, Liu X. SUMO-1 modification of MEF2A regulates its transcriptional activity. J Cell Mol Med. 2006 Jan-Mar; 10(1):132-44. PMID: 16563226.
      View in: PubMed
    49. Wang W, Nacusi L, Sheaff RJ, Liu X. Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection. Biochemistry. 2005 Nov 08; 44(44):14553-64. PMID: 16262255.
      View in: PubMed
    50. Knuesel M, Cheung HT, Hamady M, Barthel KK, Liu X. A method of mapping protein sumoylation sites by mass spectrometry using a modified small ubiquitin-like modifier 1 (SUMO-1) and a computational program. Mol Cell Proteomics. 2005 Oct; 4(10):1626-36. PMID: 16020427.
      View in: PubMed
    51. Ungermannova D, Gao Y, Liu X. Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2. J Biol Chem. 2005 Aug 26; 280(34):30301-9. PMID: 15980415.
      View in: PubMed
    52. Wang W, Ungermannova D, Chen L, Liu X. Molecular and biochemical characterization of the Skp2-Cks1 binding interface. J Biol Chem. 2004 Dec 03; 279(49):51362-9. PMID: 15452136.
      View in: PubMed
    53. Macdonald M, Wan Y, Wang W, Roberts E, Cheung TH, Erickson R, Knuesel MT, Liu X. Control of cell cycle-dependent degradation of c-Ski proto-oncoprotein by Cdc34. Oncogene. 2004 Jul 22; 23(33):5643-53. PMID: 15122324.
      View in: PubMed
    54. Wang W, Ungermannova D, Jin J, Harper JW, Liu X. Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling. Oncogene. 2004 Feb 05; 23(5):1064-75. PMID: 14676846.
      View in: PubMed
    55. Knuesel M, Wan Y, Xiao Z, Holinger E, Lowe N, Wang W, Liu X. Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system. Mol Cell Proteomics. 2003 Nov; 2(11):1225-33. PMID: 12963786.
      View in: PubMed
    56. Wang W, Ungermannova D, Chen L, Liu X. A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1. J Biol Chem. 2003 Aug 22; 278(34):32390-6. PMID: 12813041.
      View in: PubMed
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