Factor XIa
"Factor XIa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa in the presence of cofactor HMWK; (HIGH MOLECULAR WEIGHT KININOGEN). Factor XIa then activates factor IX to factor IXa in the presence of calcium.
Descriptor ID |
D015945
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MeSH Number(s) |
D08.811.277.656.300.760.320 D08.811.277.656.959.350.320 D12.776.124.125.425.320 D23.119.425.320
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Concept/Terms |
Factor XIa- Factor XIa
- Factor Eleven A
- Activated Factor XI
- Coagulation Factor XIa
- Factor XIa, Coagulation
- Blood Coagulation Factor XI, Activated
- Contact Activation Product
- Factor 11A
- Factor XI, Activated
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Below are MeSH descriptors whose meaning is more general than "Factor XIa".
Below are MeSH descriptors whose meaning is more specific than "Factor XIa".
This graph shows the total number of publications written about "Factor XIa" by people in this website by year, and whether "Factor XIa" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 1 | 1 | 1998 | 1 | 0 | 1 |
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Below are the most recent publications written about "Factor XIa" by people in Profiles.
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Kjalke M, Monroe DM, Hoffman M, Oliver JA, Ezban M, Roberts HR. Active site-inactivated factors VIIa, Xa, and IXa inhibit individual steps in a cell-based model of tissue factor-initiated coagulation. Thromb Haemost. 1998 Oct; 80(4):578-84.
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Chang JY, Monroe DM, Stafford DW, Brinkhous KM, Roberts HR. Replacing the first epidermal growth factor-like domain of factor IX with that of factor VII enhances activity in vitro and in canine hemophilia B. J Clin Invest. 1997 Aug 15; 100(4):886-92.
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Noyes CM, Griffith MJ, Roberts HR, Lundblad RL. Identification of the molecular defect in factor IX Chapel Hill: substitution of histidine for arginine at position 145. Proc Natl Acad Sci U S A. 1983 Jul; 80(14):4200-2.
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Braunstein KM, Noyes CM, Griffith MJ, Lundblad RL, Roberts HR. Characterization of the defect in activation of factor IX Chapel Hill by human factor XIa. J Clin Invest. 1981 Dec; 68(6):1420-6.
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