 Tumor Suppressor Protein p14ARF
"Tumor Suppressor Protein p14ARF" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.
| Descriptor ID |
D025803
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| MeSH Number(s) |
D12.776.167.600 D12.776.624.776.772
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor Protein p14ARF".
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This graph shows the total number of publications written about "Tumor Suppressor Protein p14ARF" by people in this website by year, and whether "Tumor Suppressor Protein p14ARF" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1999 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 2 | 0 | 2 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tumor Suppressor Protein p14ARF" by people in Profiles.
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Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Komori H, Ohtani K. Cancer cell specific cytotoxic gene expression mediated by ARF tumor suppressor promoter constructs. Biochem Biophys Res Commun. 2014 Jul 18; 450(1):240-6.
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Walker GJ, Soyer HP, Handoko HY, Ferguson B, Kunisada T, Khosrotehrani K, Box NF, Muller HK. Superficial spreading-like melanoma in Arf(-/-)::Tyr-Nras(Q61K)::K14-Kitl mice: keratinocyte Kit ligand expression sufficient to "translocate" melanomas from dermis to epidermis. J Invest Dermatol. 2011 Jun; 131(6):1384-7.
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Box NF, Terzian T. The role of p53 in pigmentation, tanning and melanoma. Pigment Cell Melanoma Res. 2008 Oct; 21(5):525-33.
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Rovin RA, Winn R. Pokemon expression in malignant glioma: an application of bioinformatics methods. Neurosurg Focus. 2005 Oct 15; 19(4):E8.
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Komori H, Enomoto M, Nakamura M, Iwanaga R, Ohtani K. Distinct E2F-mediated transcriptional program regulates p14ARF gene expression. EMBO J. 2005 Nov 02; 24(21):3724-36.
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Gregory MA, Qi Y, Hann SR. The ARF tumor suppressor: keeping Myc on a leash. Cell Cycle. 2005 Feb; 4(2):249-52.
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Qi Y, Gregory MA, Li Z, Brousal JP, West K, Hann SR. p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature. 2004 Oct 07; 431(7009):712-7.
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Zhu JW, DeRyckere D, Li FX, Wan YY, DeGregori J. A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection. Cell Growth Differ. 1999 Dec; 10(12):829-38.
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