Securin
"Securin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.
| Descriptor ID |
D064249
|
| MeSH Number(s) |
D12.776.167.504
|
| Concept/Terms |
Securin- Securin
- Pituitary Tumor-Transforming Proteins
- Pituitary Tumor Transforming Proteins
- PTTG Protein
- Pituitary Tumor-Transforming Gene Protein
|
Below are MeSH descriptors whose meaning is more general than "Securin".
Below are MeSH descriptors whose meaning is more specific than "Securin".
This graph shows the total number of publications written about "Securin" by people in this website by year, and whether "Securin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Securin" by people in Profiles.
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DeGregori J. Of mice, genes and aging. Haematologica. 2020; 105(2):246-248.
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Nakachi I, Helfrich BA, Spillman MA, Mickler EA, Olson CJ, Rice JL, Coldren CD, Heasley LE, Geraci MW, Stearman RS. PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines. Clin Transl Sci. 2016 12; 9(6):293-301.