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Andrew Peter Bradford

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OB/GYN RS GENERAL OPS
Phone303/724-3507

    Collapse Research 
    Collapse research activities and funding
    R01CA104875     (BRADFORD, ANDREW P)Apr 1, 2004 - Feb 28, 2010
    NIH
    THE ROLE OF PROTEIN KINASE C IN ENDOMETRIAL CANCER
    Role: Principal Investigator
    R01DK053496     (BRADFORD, ANDREW P)Aug 14, 1998 - Jun 30, 2003
    NIH
    FGF SIGNALING AND PITUITARY TUMORIGENESIS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Santoro N, Kuhn K, Pretzel S, Schauer IE, Fought A, D'Alessandro A, Stephenson D, Bradford AP. A high-fat eucaloric diet induces reprometabolic syndrome of obesity in normal weight women. PNAS Nexus. 2024 Jan; 3(1):pgad440. PMID: 38178979.
      View in: PubMed
    2. Zhou Y, Nakajima R, Shirasawa M, Fikriyanti M, Zhao L, Iwanaga R, Bradford AP, Kurayoshi K, Araki K, Ohtani K. Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression. Biology (Basel). 2023 Dec 11; 12(12). PMID: 38132337.
      View in: PubMed
    3. Luu TH, Kuhn K, Bradford AP, Wempe MF, Wittenburg L, Johnson RL, Carlson NE, Kumar TR, Polotsky AJ. Effects of pulsatile intravenous follicle-stimulating hormone treatment on ovarian function in women with obesity. Fertil Steril. 2023 10; 120(4):890-898. PMID: 37276947.
      View in: PubMed
    4. Nakajima R, Deguchi R, Komori H, Zhao L, Zhou Y, Shirasawa M, Angelina A, Goto Y, Tohjo F, Nakahashi K, Nakata K, Iwanaga R, Bradford AP, Araki K, Warita T, Ohtani K. The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F. Biochem Biophys Res Commun. 2023 06 30; 663:154-162. PMID: 37141667.
      View in: PubMed
    5. Nakajima R, Zhao L, Zhou Y, Shirasawa M, Uchida A, Murakawa H, Fikriyanti M, Iwanaga R, Bradford AP, Araki K, Warita T, Ohtani K. Deregulated E2F Activity as a Cancer-Cell Specific Therapeutic Tool. Genes (Basel). 2023 02 02; 14(2). PMID: 36833320.
      View in: PubMed
    6. McDonald R, Kuhn K, Nguyen TB, Tannous A, Schauer I, Santoro N, Bradford AP. A randomized clinical trial demonstrating cell type specific effects of hyperlipidemia and hyperinsulinemia on pituitary function. PLoS One. 2022; 17(5):e0268323. PMID: 35544473.
      View in: PubMed
    7. Kohn SA, Fought AJ, Kuhn K, Jones Slogett K, Bradford AP, Santoro N, Schauer I. Heparin Effects on Serum Gonadotropins. J Endocr Soc. 2022 Jan 01; 6(1):bvab178. PMID: 35024539.
      View in: PubMed
    8. Moroney MR, Woodruff E, Qamar L, Bradford AP, Wolsky R, Bitler BG, Corr BR. Inhibiting Wnt/beta-catenin in CTNNB1-mutated endometrial cancer. Mol Carcinog. 2021 08; 60(8):511-523. PMID: 34038589.
      View in: PubMed
    9. Santoro N, Schauer IE, Kuhn K, Fought AJ, Babcock-Gilbert S, Bradford AP. Gonadotropin response to insulin and lipid infusion reproduces the reprometabolic syndrome of obesity in eumenorrheic lean women: a randomized crossover trial. Fertil Steril. 2021 08; 116(2):566-574. PMID: 33838870.
      View in: PubMed
    10. Tannous A, Bradford AP, Kuhn K, Fought A, Schauer I, Santoro N. A randomised trial examining inflammatory signaling in acutely induced hyperinsulinemia and hyperlipidemia in normal weight women-the reprometabolic syndrome. PLoS One. 2021; 16(3):e0247638. PMID: 33764994.
      View in: PubMed
    11. Jones K, Ryan S, Carlson NE, Chosich J, Bradford AP, Santoro N, Polotsky AJ. Aromatase Inhibition Ameliorates Decreased LH Output Found in Obese Women. Reprod Sci. 2020 04; 27(4):1018-1023. PMID: 32046430.
      View in: PubMed
    12. Adams CL, Dimitrova I, Post MD, Gibson L, Spillman MA, Behbakht K, Bradford AP. Identification of a novel diagnostic gene expression signature to discriminate uterine leiomyoma from leiomyosarcoma. Exp Mol Pathol. 2019 10; 110:104284. PMID: 31301306.
      View in: PubMed
    13. Bauer JL, Kuhn K, Bradford AP, Al-Safi ZA, Harris MA, Eckel RH, Robledo CY, Malkhasyan A, Johnson J, Gee NR, Polotsky AJ. Reduction in FSH Throughout the Menstrual Cycle After Omega-3 Fatty Acid Supplementation in Young Normal Weight but not Obese Women. Reprod Sci. 2019 08; 26(8):1025-1033. PMID: 30773100.
      View in: PubMed
    14. Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani K. Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes. Sci Rep. 2018 05 31; 8(1):8438. PMID: 29855511.
      View in: PubMed
    15. Al-Safi ZA, Polotsky A, Chosich J, Roth L, Allshouse AA, Bradford AP, Santoro N. Evidence for disruption of normal circadian cortisol rhythm in women with obesity. Gynecol Endocrinol. 2018 Apr; 34(4):336-340. PMID: 29068243.
      View in: PubMed
    16. Chosich J, Bradford AP, Allshouse AA, Reusch JE, Santoro N, Schauer IE. Acute recapitulation of the hyperinsulinemia and hyperlipidemia characteristic of metabolic syndrome suppresses gonadotropins. Obesity (Silver Spring). 2017 03; 25(3):553-560. PMID: 28158916.
      View in: PubMed
    17. Kurayoshi K, Shiromoto A, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani K. Ectopic expression of the CDK inhibitor p21Cip1 enhances deregulated E2F activity and increases cancer cell-specific cytotoxic gene expression mediated by the ARF tumor suppressor promoter. Biochem Biophys Res Commun. 2017 01 29; 483(1):107-114. PMID: 28042030.
      View in: PubMed
    18. Kurayoshi K, Okuno J, Ozono E, Iwanaga R, Bradford AP, Kugawa K, Araki K, Ohtani K. The phosphatidyl inositol 3 kinase pathway does not suppress activation of the ARF and BIM genes by deregulated E2F1 activity. Biochem Biophys Res Commun. 2017 Jan 22; 482(4):784-790. PMID: 27888102.
      View in: PubMed
    19. Kuokkanen S, Polotsky AJ, Chosich J, Bradford AP, Jasinska A, Phang T, Santoro N, Appt SE. Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med. 2016 Aug; 62(4):227-42. PMID: 27187064.
      View in: PubMed
    20. Al-Safi ZA, Liu H, Carlson NE, Chosich J, Harris M, Bradford AP, Robledo C, Eckel RH, Polotsky AJ. Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women. J Clin Endocrinol Metab. 2016 Jan; 101(1):324-33. PMID: 26523525.
      View in: PubMed
    21. Al-Safi ZA, Liu H, Carlson NE, Chosich J, Lesh J, Robledo C, Bradford AP, Gee NA, Phang T, Santoro N, Kohrt W, Polotsky AJ. Estradiol Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese Women. J Clin Endocrinol Metab. 2015 Nov; 100(11):4372-81. PMID: 26425884.
      View in: PubMed
    22. Noshchenko A, Hoffecker L, Lindley EM, Burger EL, Cain CM, Patel VV, Bradford AP. Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis. World J Orthop. 2015 Aug 18; 6(7):537-58. PMID: 26301183.
      View in: PubMed
    23. Bradford AP, Jones K, Kechris K, Chosich J, Montague M, Warren WC, May MC, Al-Safi Z, Kuokkanen S, Appt SE, Polotsky AJ. Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain. PLoS One. 2015; 10(8):e0135163. PMID: 26258540.
      View in: PubMed
    24. Kitamura H, Ozono E, Iwanaga R, Bradford AP, Okuno J, Shimizu E, Kurayoshi K, Kugawa K, Toh H, Ohtani K. Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts. Genes Cells. 2015 Sep; 20(9):739-57. PMID: 26201719.
      View in: PubMed
    25. Merhi Z, Polotsky AJ, Bradford AP, Buyuk E, Chosich J, Phang T, Jindal S, Santoro N. Adiposity Alters Genes Important in Inflammation and Cell Cycle Division in Human Cumulus Granulosa Cell. Reprod Sci. 2015 Oct; 22(10):1220-8. PMID: 25676576.
      View in: PubMed
    26. Wooding KM, Hankin JA, Johnson CA, Chosich JD, Baek SW, Bradford AP, Murphy RC, Santoro N. Measurement of estradiol, estrone, and testosterone in postmenopausal human serum by isotope dilution liquid chromatography tandem mass spectrometry without derivatization. Steroids. 2015 Apr; 96:89-94. PMID: 25617740.
      View in: PubMed
    27. Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Komori H, Ohtani K. Cancer cell specific cytotoxic gene expression mediated by ARF tumor suppressor promoter constructs. Biochem Biophys Res Commun. 2014 Jul 18; 450(1):240-6. PMID: 24893334.
      View in: PubMed
    28. Roth LW, Allshouse AA, Bradshaw-Pierce EL, Lesh J, Chosich J, Kohrt W, Bradford AP, Polotsky AJ, Santoro N. Luteal phase dynamics of follicle-stimulating and luteinizing hormones in obese and normal weight women. Clin Endocrinol (Oxf). 2014 Sep; 81(3):418-25. PMID: 24576183.
      View in: PubMed
    29. Roth LW, Bradshaw-Pierce EL, Allshouse AA, Lesh J, Chosich J, Bradford AP, Polotsky AJ, Santoro N. Evidence of GnRH antagonist escape in obese women. J Clin Endocrinol Metab. 2014 May; 99(5):E871-5. PMID: 24650013.
      View in: PubMed
    30. Ross LA, Polotsky AJ, Kucherov A, Bradford AP, Lesh J, Chosich J, Gee N, Santoro N. Profound reduction of ovarian estrogen by aromatase inhibition in obese women. Obesity (Silver Spring). 2014 Jun; 22(6):1464-9. PMID: 24482405.
      View in: PubMed
    31. Dai D, Bradford AP, Prossnitz ER. Endometrial cancer: molecular and cellular basis of tumor development, novel biomarkers and therapeutic agents, and innovative research approaches. Obstet Gynecol Int. 2014; 2014:710405. PMID: 24550988.
      View in: PubMed
    32. Wooding KM, Barkley RM, Hankin JA, Johnson CA, Bradford AP, Santoro N, Murphy RC. Mechanism of formation of the major estradiol product ions following collisional activation of the molecular anion in a tandem quadrupole mass spectrometer. J Am Soc Mass Spectrom. 2013 Oct; 24(10):1451-5. PMID: 23955001.
      View in: PubMed
    33. Thorne AM, Jackson TA, Willis VC, Bradford AP. Protein Kinase C a Modulates Estrogen-Receptor-Dependent Transcription and Proliferation in Endometrial Cancer Cells. Obstet Gynecol Int. 2013; 2013:537479. PMID: 23843797.
      View in: PubMed
    34. Kundu MC, May MC, Chosich J, Bradford AP, Lasley B, Gee N, Santoro N, Appt SE, Polotsky AJ. Assessment of luteal function in the vervet monkey as a means to develop a model for obesity-related reproductive phenotype. Syst Biol Reprod Med. 2013 Apr; 59(2):74-81. PMID: 23278149.
      View in: PubMed
    35. Iwanaga R, Wang CA, Micalizzi DS, Harrell JC, Jedlicka P, Sartorius CA, Kabos P, Farabaugh SM, Bradford AP, Ford HL. Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways. Breast Cancer Res. 2012 Jul 05; 14(4):R100. PMID: 22765220.
      View in: PubMed
    36. Korch C, Spillman MA, Jackson TA, Jacobsen BM, Murphy SK, Lessey BA, Jordan VC, Bradford AP. DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination. Gynecol Oncol. 2012 Oct; 127(1):241-8. PMID: 22710073.
      View in: PubMed
    37. Georgieva B, Milev I, Minkov I, Dimitrova I, Bradford AP, Baev V. Characterization of the uterine leiomyoma microRNAome by deep sequencing. Genomics. 2012 May; 99(5):275-81. PMID: 22446413.
      View in: PubMed
    38. Kucherov A, Polotsky AJ, Menke M, Isaac B, McAvey B, Buyuk E, Bradford AP, Hickmon C, Babbs B, Berga S, Loucks T, Santoro N. Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal women. Fertil Steril. 2011 May; 95(6):2063-6. PMID: 21353673.
      View in: PubMed
    39. Haughian JM, Reno EM, Thorne AM, Bradford AP. Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. Int J Cancer. 2009 Dec 01; 125(11):2556-64. PMID: 19672862.
      View in: PubMed
    40. Haughian JM, Bradford AP. Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells. J Cell Physiol. 2009 Jul; 220(1):112-8. PMID: 19235902.
      View in: PubMed
    41. Reno EM, Haughian JM, Jackson TA, Thorne AM, Bradford AP. c-Jun N-terminal kinase regulates apoptosis in endometrial cancer cells. Apoptosis. 2009 Jun; 14(6):809-20. PMID: 19424800.
      View in: PubMed
    42. Dimitrova IK, Richer JK, Rudolph MC, Spoelstra NS, Reno EM, Medina TM, Bradford AP. Gene expression profiling of multiple leiomyomata uteri and matched normal tissue from a single patient. Fertil Steril. 2009 Jun; 91(6):2650-63. PMID: 18672237.
      View in: PubMed
    43. Reno EM, Haughian JM, Dimitrova IK, Jackson TA, Shroyer KR, Bradford AP. Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors. Hum Pathol. 2008 Jan; 39(1):21-9. PMID: 17959229.
      View in: PubMed
    44. Gutierrez-Hartmann A, Duval DL, Bradford AP. ETS transcription factors in endocrine systems. Trends Endocrinol Metab. 2007 May-Jun; 18(4):150-8. PMID: 17387021.
      View in: PubMed
    45. Haughian JM, Jackson TA, Koterwas DM, Bradford AP. Endometrial cancer cell survival and apoptosis is regulated by protein kinase C alpha and delta. Endocr Relat Cancer. 2006 Dec; 13(4):1251-67. PMID: 17158769.
      View in: PubMed
    46. Siriwardana G, Bradford A, Coy D, Zeitler P. Autocrine/paracrine regulation of breast cancer cell proliferation by growth hormone releasing hormone via Ras, Raf, and mitogen-activated protein kinase. Mol Endocrinol. 2006 Sep; 20(9):2010-9. PMID: 16613992.
      View in: PubMed
    47. Jackson TA, Koterwas DM, Bradford AP. Differential regulation of cell growth and gene expression by FGF-2 and FGF-4 in pituitary lactotroph GH4 cells. Mol Cell Endocrinol. 2006 Mar 09; 247(1-2):183-91. PMID: 16469431.
      View in: PubMed
    48. Farrow KN, Bradford AP, Tentler JJ, Gutierrez-Hartmann A. Structural and functional analysis of the differential effects of c-Jun and v-Jun on prolactin gene expression. Mol Endocrinol. 2004 Oct; 18(10):2479-90. PMID: 15231872.
      View in: PubMed
    49. Jackson TA, Koterwas DM, Morgan MA, Bradford AP. Fibroblast growth factors regulate prolactin transcription via an atypical Rac-dependent signaling pathway. Mol Endocrinol. 2003 Oct; 17(10):1921-30. PMID: 12843210.
      View in: PubMed
    50. Tentler JJ, Bradford AP, Schweppe RE, Gutierrez-Hartmann A. Selective repression of rat prolactin gene by stable expression of dominant-negative Ets in GH4 pituitary cells. Endocrine. 2003 Feb-Mar; 20(1-2):3-12. PMID: 12668863.
      View in: PubMed
    51. Bradford AP, Brodsky KS, Diamond SE, Kuhn LC, Liu Y, Gutierrez-Hartmann A. The Pit-1 homeodomain and beta-domain interact with Ets-1 and modulate synergistic activation of the rat prolactin promoter. J Biol Chem. 2000 Feb 04; 275(5):3100-6. PMID: 10652292.
      View in: PubMed
    52. Schweppe RE, Frazer-Abel AA, Gutierrez-Hartmann A, Bradford AP. Functional components of fibroblast growth factor (FGF) signal transduction in pituitary cells. Identification of FGF response elements in the prolactin gene. J Biol Chem. 1997 Dec 05; 272(49):30852-9. PMID: 9388230.
      View in: PubMed
    53. Bradford AP, Wasylyk C, Wasylyk B, Gutierrez-Hartmann A. Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression. Mol Cell Biol. 1997 Mar; 17(3):1065-74. PMID: 9032233.
      View in: PubMed
    54. Wasylyk C, Bradford AP, Gutierrez-Hartmann A, Wasylyk B. Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2. Oncogene. 1997 Feb 27; 14(8):899-913. PMID: 9050989.
      View in: PubMed
    55. Bradford AP, Conrad KE, Tran PH, Ostrowski MC, Gutierrez-Hartmann A. GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element. J Biol Chem. 1996 Oct 04; 271(40):24639-48. PMID: 8798730.
      View in: PubMed
    56. Bradford AP, Conrad KE, Wasylyk C, Wasylyk B, Gutierrez-Hartmann A. Functional interaction of c-Ets-1 and GHF-1/Pit-1 mediates Ras activation of pituitary-specific gene expression: mapping of the essential c-Ets-1 domain. Mol Cell Biol. 1995 May; 15(5):2849-57. PMID: 7739565.
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    57. Wolfe L, Bradford AP, Klarlund JK, Czech MP. Purification and characterization of a cytosolic insulin-stimulated serine kinase from rat liver. J Biol Chem. 1992 May 15; 267(14):9749-56. PMID: 1533638.
      View in: PubMed
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