 PHD Zinc Fingers
"PHD Zinc Fingers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates binding of two zinc ions. They are similar structurally to RING FINGER DOMAINS, with a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. PHD fingers occur in many proteins that function in chromatin-mediated gene expression and EPIGENETICS such as POLYCOMB-GROUP PROTEINS.
| Descriptor ID |
D000075925
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| MeSH Number(s) |
G02.111.570.820.709.275.500.985.438
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| Concept/Terms |
PHD Zinc Fingers- PHD Zinc Fingers
- Finger, PHD Zinc
- Fingers, PHD Zinc
- Zinc Finger, PHD
- Zinc Fingers, PHD
- PHD Fingers
- Finger, PHD
- Fingers, PHD
- PHD Finger
- PHD Motifs
- PHD Domains
- Domain, PHD
- Domains, PHD
- PHD Domain
- PHD Zinc Finger
- PHD Finger Domain
- Domain, PHD Finger
- Domains, PHD Finger
- Finger Domain, PHD
- Finger Domains, PHD
- PHD Finger Domains
- PHD Motif
- Motif, PHD
- Motifs, PHD
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Below are MeSH descriptors whose meaning is more general than "PHD Zinc Fingers".
Below are MeSH descriptors whose meaning is more specific than "PHD Zinc Fingers".
This graph shows the total number of publications written about "PHD Zinc Fingers" by people in this website by year, and whether "PHD Zinc Fingers" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 2 | 1 | 3 | | 2020 | 0 | 1 | 1 | | 2023 | 3 | 0 | 3 |
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Below are the most recent publications written about "PHD Zinc Fingers" by people in Profiles.
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Kumar Sinha V, Zhang Y, Xu L, Chen YW, Picaud S, Zandian M, Biswas S, Filippakopoulos P, Wang SP, Shi X, Kutateladze TG. Histone H4K16ac Binding Function of the Triple PHD Finger Cassette of MLL4. J Mol Biol. 2024 Apr 01; 436(7):168212.
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Gaurav N, Kutateladze TG. Non-histone binding functions of PHD fingers. Trends Biochem Sci. 2023 07; 48(7):610-617.
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Black JC, Kutateladze TG. Atypical histone targets of PHD fingers. J Biol Chem. 2023 04; 299(4):104601.
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Zhang Y, Guo Y, Gough SM, Zhang J, Vann KR, Li K, Cai L, Shi X, Aplan PD, Wang GG, Kutateladze TG. Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun. 2020 07 03; 11(1):3339.
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Mondal P, Sen S, Klein BJ, Tiwary N, Gadad SS, Kutateladze TG, Roy S, Das C. TCF19 Promotes Cell Proliferation through Binding to the Histone H3K4me3 Mark. Biochemistry. 2020 02 04; 59(4):389-399.
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Musselman CA, Kutateladze TG. The PHD finger of Spp1 mediates histone modification cross-talk. Biochem J. 2019 08 28; 476(16):2351-2354.
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Zhang Y, Jang Y, Lee JE, Ahn J, Xu L, Holden MR, Cornett EM, Krajewski K, Klein BJ, Wang SP, Dou Y, Roeder RG, Strahl BD, Rothbart SB, Shi X, Ge K, Kutateladze TG. Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF. Nat Commun. 2019 05 24; 10(1):2314.
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Morrison EA, Bowerman S, Sylvers KL, Wereszczynski J, Musselman CA. The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome. Elife. 2018 04 12; 7.
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Tencer AH, Gatchalian J, Klein BJ, Khan A, Zhang Y, Strahl BD, van Wely KHM, Kutateladze TG. A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO. Structure. 2017 10 03; 25(10):1530-1539.e3.
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