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Catherine Anne Musselman

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

    Collapse Research 
    Collapse research activities and funding
    R35GM128705     (MUSSELMAN, CATHERINE ANNE)Aug 1, 2018 - Jul 31, 2023
    NIH
    Molecular mechanisms of histone signaling in a chromatin relevant context
    Role: Principal Investigator
    F32HL096399     (MUSSELMAN, CATHERINE ANNE)Aug 1, 2009 - Jul 31, 2012
    NIH
    Structural insight into the role of CHD4 PHD fingers.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Akbari E, Park EJ, Singh AK, Vinayak V, Virk RKA, Wereszczynksi J, Musselman CA. Multiscale genome organization symposium - annual biophysical society meeting 2023. Biophys Rev. 2023 Jun; 15(3):313-315. PMID: 37396443.
      View in: PubMed
    2. De Silva SM, Dhiman A, Sood S, Mercedes KF, Simmons WJ, Henen MA, V?geli B, Dykhuizen EC, Musselman CA. PBRM1 bromodomains associate with RNA to facilitate chromatin association. Nucleic Acids Res. 2023 05 08; 51(8):3631-3649. PMID: 36808431.
      View in: PubMed
    3. Ghoneim M, Musselman CA. Protocol to prepare doubly labeled fluorescent nucleosomes for single-molecule fluorescence microscopy. STAR Protoc. 2023 Apr 19; 4(2):102229. PMID: 37083320.
      View in: PubMed
    4. Ghoneim M, Musselman CA. Single-Molecule Characterization of Cy3.5 -Cy5.5 Dye Pair for FRET Studies of Nucleic Acids and Nucleosomes. J Fluoresc. 2023 Mar; 33(2):413-421. PMID: 36435903.
      View in: PubMed
    5. Musselman CA, Valkov E. Dynamic views of molecular recognition in protein-nucleic acid complexes. Curr Opin Struct Biol. 2022 Nov 16; 77:102500. PMID: 36402027.
      View in: PubMed
    6. Musselman C, Kanelis V, Lecomte S, Strodel B. Editorial for the special issue "A Celebration of Women in Biophysical Chemistry". Biophys Chem. 2023 01; 292:106929. PMID: 36371933.
      View in: PubMed
    7. Musselman CA, Kutateladze TG. Visualizing Conformational Ensembles of the Nucleosome by NMR. ACS Chem Biol. 2022 03 18; 17(3):495-502. PMID: 35196453.
      View in: PubMed
    8. Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chem Biol. 2022 04 21; 29(4):555-571.e11. PMID: 34715055.
      View in: PubMed
    9. Morrison EA, Baweja L, Poirier MG, Wereszczynski J, Musselman CA. Nucleosome composition regulates the histone H3 tail conformational ensemble and accessibility. Nucleic Acids Res. 2021 05 07; 49(8):4750-4767. PMID: 33856458.
      View in: PubMed
    10. Ghoneim M, Fuchs HA, Musselman CA. Histone Tail Conformations: A Fuzzy Affair with DNA. Trends Biochem Sci. 2021 07; 46(7):564-578. PMID: 33551235.
      View in: PubMed
    11. Lupo BE, Chu P, Harms MJ, Morrison EA, Musselman CA. Evolutionary Conservation of Structural and Functional Coupling between the BRM AT-Hook and Bromodomain. J Mol Biol. 2021 07 09; 433(14):166845. PMID: 33539881.
      View in: PubMed
    12. Musselman CA, Kutateladze TG. Characterization of functional disordered regions within chromatin-associated proteins. iScience. 2021 Feb 19; 24(2):102070. PMID: 33604523.
      View in: PubMed
    13. Sanchez JC, Zhang L, Evoli S, Schnicker NJ, Nunez-Hernandez M, Yu L, Wereszczynski J, Pufall MA, Musselman CA. The molecular basis of selective DNA binding by the BRG1 AT-hook and bromodomain. Biochim Biophys Acta Gene Regul Mech. 2020 08; 1863(8):194566. PMID: 32376391.
      View in: PubMed
    14. Wang S, Denton KE, Hobbs KF, Weaver T, McFarlane JMB, Connelly KE, Gignac MC, Milosevich N, Hof F, Paci I, Musselman CA, Dykhuizen EC, Krusemark CJ. Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor. ACS Chem Biol. 2020 01 17; 15(1):112-131. PMID: 31755685.
      View in: PubMed
    15. Musselman CA, Kutateladze TG. The PHD finger of Spp1 mediates histone modification cross-talk. Biochem J. 2019 08 28; 476(16):2351-2354. PMID: 31462441.
      View in: PubMed
    16. Li Y, Xie N, Chen R, Lee AR, Lovnicki J, Morrison EA, Fazli L, Zhang Q, Musselman CA, Wang Y, Huang J, Gleave ME, Collins C, Dong X. RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression. Eur Urol. 2019 08; 76(2):157-166. PMID: 30910347.
      View in: PubMed
    17. Connelly KE, Weaver TM, Alpsoy A, Gu BX, Musselman CA, Dykhuizen EC. Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association. Nucleic Acids Res. 2019 03 18; 47(5):2289-2305. PMID: 30597065.
      View in: PubMed
    18. Musselman CA, Kutateladze TG. Strategies for Generating Modified Nucleosomes: Applications within Structural Biology Studies. ACS Chem Biol. 2019 04 19; 14(4):579-586. PMID: 30817115.
      View in: PubMed
    19. Weaver TM, Liu J, Connelly KE, Coble C, Varzavand K, Dykhuizen EC, Musselman CA. The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail. Sci Rep. 2019 01 30; 9(1):987. PMID: 30700785.
      View in: PubMed
    20. Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, Hall D, Wu J, Shi Y, Zhu Q, Chen C, Thiel WH, Zhan X, Weiss RM, Zhan F, Musselman CA, Pufall M, Zhu W, Au KF, Hong J, Anderson ME, Grueter CE, Song LS. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018 12 21; 362(6421). PMID: 30409805.
      View in: PubMed
    21. Weaver TM, Morrison EA, Musselman CA. Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains. Molecules. 2018 Oct 12; 23(10). PMID: 30322003.
      View in: PubMed
    22. Musselman CA, Kutateladze TG. A histone reader becomes the readout. J Biol Chem. 2018 05 11; 293(19):7486-7487. PMID: 29752422.
      View in: PubMed
    23. Morrison EA, Bowerman S, Sylvers KL, Wereszczynski J, Musselman CA. The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome. Elife. 2018 04 12; 7. PMID: 29648537.
      View in: PubMed
    24. Gatchalian J, Wang X, Ikebe J, Cox KL, Tencer AH, Zhang Y, Burge NL, Di L, Gibson MD, Musselman CA, Poirier MG, Kono H, Hayes JJ, Kutateladze TG. Accessibility of the histone H3 tail in the nucleosome for binding of paired readers. Nat Commun. 2017 11 14; 8(1):1489. PMID: 29138400.
      View in: PubMed
    25. Tencer AH, Cox KL, Di L, Bridgers JB, Lyu J, Wang X, Sims JK, Weaver TM, Allen HF, Zhang Y, Gatchalian J, Darcy MA, Gibson MD, Ikebe J, Li W, Wade PA, Hayes JJ, Strahl BD, Kono H, Poirier MG, Musselman CA, Kutateladze TG. Covalent Modifications of Histone H3K9 Promote Binding of CHD3. Cell Rep. 2017 Oct 10; 21(2):455-466. PMID: 29020631.
      View in: PubMed
    26. Morrison EA, Sanchez JC, Ronan JL, Farrell DP, Varzavand K, Johnson JK, Gu BX, Crabtree GR, Musselman CA. DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes. Nat Commun. 2017 07 14; 8:16080. PMID: 28706277.
      View in: PubMed
    27. Flenker KS, Burghardt EL, Dutta N, Burns WJ, Grover JM, Kenkel EJ, Weaver TM, Mills J, Kim H, Huang L, Owczarzy R, Musselman CA, Behlke MA, Ford B, McNamara JO. Rapid Detection of Urinary Tract Infections via Bacterial Nuclease Activity. Mol Ther. 2017 06 07; 25(6):1353-1362. PMID: 28391960.
      View in: PubMed
    28. Xing S, Li F, Zeng Z, Zhao Y, Yu S, Shan Q, Li Y, Phillips FC, Maina PK, Qi HH, Liu C, Zhu J, Pope RM, Musselman CA, Zeng C, Peng W, Xue HH. Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. Nat Immunol. 2016 06; 17(6):695-703. PMID: 27111144.
      View in: PubMed
    29. Musselman CA, Kutateladze TG. Preparation, Biochemical Analysis, and Structure Determination of Methyllysine Readers. Methods Enzymol. 2016; 573:345-62. PMID: 27372761.
      View in: PubMed
    30. Tong Q, Cui G, Botuyan MV, Rothbart SB, Hayashi R, Musselman CA, Singh N, Appella E, Strahl BD, Mer G, Kutateladze TG. Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1. Structure. 2015 Feb 03; 23(2):312-21. PMID: 25579814.
      View in: PubMed
    31. Wang C, Chen Z, Hong X, Ning F, Liu H, Zang J, Yan X, Kemp J, Musselman CA, Kutateladze TG, Zhao R, Jiang C, Zhang G. The structural basis of urea-induced protein unfolding in ?-catenin. Acta Crystallogr D Biol Crystallogr. 2014 Nov; 70(Pt 11):2840-7. PMID: 25372676.
      View in: PubMed
    32. Ezhov RN, Metzel GA, Mukhina OA, Musselman CA, Kutateladze TG, Gustafson TP, Kutateladze AG. Photoactive Spatial Proximity Probes for Binding Pairs with Epigenetic Marks. J Photochem Photobiol A Chem. 2014 Sep 15; 290:101-108. PMID: 25197204.
      View in: PubMed
    33. Allen HF, Daze KD, Shimbo T, Lai A, Musselman CA, Sims JK, Wade PA, Hof F, Kutateladze TG. Inhibition of histone binding by supramolecular hosts. Biochem J. 2014 May 01; 459(3):505-12. PMID: 24576085.
      View in: PubMed
    34. Musselman CA, Khorasanizadeh S, Kutateladze TG. Towards understanding methyllysine readout. Biochim Biophys Acta. 2014 Aug; 1839(8):686-93. PMID: 24727128.
      View in: PubMed
    35. Musselman CA, Gibson MD, Hartwick EW, North JA, Gatchalian J, Poirier MG, Kutateladze TG. Binding of PHF1 Tudor to H3K36me3 enhances nucleosome accessibility. Nat Commun. 2013; 4:2969. PMID: 24352064.
      View in: PubMed
    36. Musselman CA, Lalonde ME, C?t? J, Kutateladze TG. Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol. 2012 Dec; 19(12):1218-27. PMID: 23211769.
      View in: PubMed
    37. Musselman CA, Avvakumov N, Watanabe R, Abraham CG, Lalonde ME, Hong Z, Allen C, Roy S, Nu?ez JK, Nickoloff J, Kulesza CA, Yasui A, C?t? J, Kutateladze TG. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nat Struct Mol Biol. 2012 Dec; 19(12):1266-72. PMID: 23142980.
      View in: PubMed
    38. Oliver SS, Musselman CA, Srinivasan R, Svaren JP, Kutateladze TG, Denu JM. Multivalent recognition of histone tails by the PHD fingers of CHD5. Biochemistry. 2012 Aug 21; 51(33):6534-44. PMID: 22834704.
      View in: PubMed
    39. Scott JL, Musselman CA, Adu-Gyamfi E, Kutateladze TG, Stahelin RV. Emerging methodologies to investigate lipid-protein interactions. Integr Biol (Camb). 2012 Mar; 4(3):247-58. PMID: 22327461.
      View in: PubMed
    40. Musselman CA, Ram?rez J, Sims JK, Mansfield RE, Oliver SS, Denu JM, Mackay JP, Wade PA, Hagman J, Kutateladze TG. Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):787-92. PMID: 22215588.
      View in: PubMed
    41. Musselman CA, Kutateladze TG. Handpicking epigenetic marks with PHD fingers. Nucleic Acids Res. 2011 Nov; 39(21):9061-71. PMID: 21813457.
      View in: PubMed
    42. Musselman CA, Kutateladze TG. Methyl fingerprinting of the nucleosome reveals the molecular mechanism of high-mobility group nucleosomal-2 (HMGN2) association. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12189-90. PMID: 21753078.
      View in: PubMed
    43. Mansfield RE, Musselman CA, Kwan AH, Oliver SS, Garske AL, Davrazou F, Denu JM, Kutateladze TG, Mackay JP. Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9. J Biol Chem. 2011 Apr 01; 286(13):11779-91. PMID: 21278251.
      View in: PubMed
    44. Hom RA, Chang PY, Roy S, Musselman CA, Glass KC, Selezneva AI, Gozani O, Ismagilov RF, Cleary ML, Kutateladze TG. Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J Mol Biol. 2010 Jul 09; 400(2):145-54. PMID: 20460131.
      View in: PubMed
    45. Chang PY, Hom RA, Musselman CA, Zhu L, Kuo A, Gozani O, Kutateladze TG, Cleary ML. Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription. J Mol Biol. 2010 Jul 09; 400(2):137-44. PMID: 20452361.
      View in: PubMed
    46. Roy S, Musselman CA, Kachirskaia I, Hayashi R, Glass KC, Nix JC, Gozani O, Appella E, Kutateladze TG. Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J Mol Biol. 2010 May 14; 398(4):489-96. PMID: 20307547.
      View in: PubMed
    47. Garske AL, Oliver SS, Wagner EK, Musselman CA, LeRoy G, Garcia BA, Kutateladze TG, Denu JM. Combinatorial profiling of chromatin binding modules reveals multisite discrimination. Nat Chem Biol. 2010 Apr; 6(4):283-90. PMID: 20190764.
      View in: PubMed
    48. Musselman C, Zhang Q, Al-Hashimi H, Andricioaei I. Referencing strategy for the direct comparison of nuclear magnetic resonance and molecular dynamics motional parameters in RNA. J Phys Chem B. 2010 Jan 21; 114(2):929-39. PMID: 20039757.
      View in: PubMed
    49. Musselman CA, Kutateladze TG. PHD fingers: epigenetic effectors and potential drug targets. Mol Interv. 2009 Dec; 9(6):314-23. PMID: 20048137.
      View in: PubMed
    50. Musselman CA, Mansfield RE, Garske AL, Davrazou F, Kwan AH, Oliver SS, O'Leary H, Denu JM, Mackay JP, Kutateladze TG. Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications. Biochem J. 2009 Sep 25; 423(2):179-87. PMID: 19624289.
      View in: PubMed
    51. He J, Vora M, Haney RM, Filonov GS, Musselman CA, Burd CG, Kutateladze AG, Verkhusha VV, Stahelin RV, Kutateladze TG. Membrane insertion of the FYVE domain is modulated by pH. Proteins. 2009 Sep; 76(4):852-60. PMID: 19296456.
      View in: PubMed
    52. Pe?a PV, Musselman CA, Kuo AJ, Gozani O, Kutateladze TG. NMR assignments and histone specificity of the ING2 PHD finger. Magn Reson Chem. 2009 Apr; 47(4):352-8. PMID: 19184981.
      View in: PubMed
    53. Dethoff EA, Hansen AL, Musselman C, Watt ED, Andricioaei I, Al-Hashimi HM. Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis. Biophys J. 2008 Oct; 95(8):3906-15. PMID: 18621815.
      View in: PubMed
    54. Musselman C, Pitt SW, Gulati K, Foster LL, Andricioaei I, Al-Hashimi HM. Impact of static and dynamic A-form heterogeneity on the determination of RNA global structural dynamics using NMR residual dipolar couplings. J Biomol NMR. 2006 Dec; 36(4):235-49. PMID: 17077936.
      View in: PubMed
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