 Prions
"Prions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
| Descriptor ID |
D011328
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| MeSH Number(s) |
D12.776.785
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Prions".
Below are MeSH descriptors whose meaning is more specific than "Prions".
This graph shows the total number of publications written about "Prions" by people in this website by year, and whether "Prions" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1999 | 1 | 0 | 1 | | 2000 | 1 | 1 | 2 | | 2002 | 1 | 1 | 2 | | 2003 | 2 | 0 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 3 | 0 | 3 | | 2013 | 2 | 1 | 3 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 1 | 2 | | 2017 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 1 | 2 | | 2021 | 1 | 0 | 1 | | 2022 | 2 | 0 | 2 | | 2023 | 1 | 0 | 1 | | 2024 | 3 | 1 | 4 |
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Below are the most recent publications written about "Prions" by people in Profiles.
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Kraft CN, Bissinger DW, McNulty EE, Denkers ND, Mathiason CK. Enhanced detection of chronic wasting disease in muscle tissue harvested from infected white-tailed deer employing combined prion amplification assays. PLoS One. 2024; 19(10):e0309918.
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Denkers ND, McNulty EE, Kraft CN, Nalls AV, Westrich JA, Hoover EA, Mathiason CK. Temporal Characterization of Prion Shedding in Secreta of White-Tailed Deer in Longitudinal Study of Chronic Wasting Disease, United States. Emerg Infect Dis. 2024 Oct; 30(10):2118-2127.
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Kincaid AE, Denkers ND, McNulty EE, Kraft CN, Bartz JC, Mathiason CK. Expression of the cellular prion protein by mast cells in white-tailed deer carotid body, cervical lymph nodes and ganglia. Prion. 2024 12; 18(1):94-102.
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Thackray AM, McNulty EE, Nalls AV, Smith A, Comoy E, Telling G, Benestad SL, Andr?oletti O, Mathiason CK, Bujdoso R. Lack of prion transmission barrier in human PrP transgenic Drosophila. J Biol Chem. 2024 Sep; 300(9):107617.
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Thackray AM, McNulty EE, Nalls AV, Cardova A, Tran L, Telling G, Benestad SL, Gilch S, Mathiason CK, Bujdoso R. Genetic modulation of CWD prion propagation in cervid PrP Drosophila. Biochem J. 2023 10 11; 480(19):1485-1501.
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Wei G, Iqbal N, Courouble VV, Francis AC, Singh PK, Hudait A, Annamalai AS, Bester S, Huang SW, Shkriabai N, Briganti L, Haney R, KewalRamani VN, Voth GA, Engelman AN, Melikyan GB, Griffin PR, Asturias F, Kvaratskhelia M. Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection. Nat Commun. 2022 10 06; 13(1):5879.
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Thackray AM, Lam B, McNulty EE, Nalls AV, Mathiason CK, Magadi SS, Jackson WS, Andr?oletti O, Marrero-Winkens C, Sch?tzl H, Bujdoso R. Clearance of variant Creutzfeldt-Jakob disease prions in vivo by the Hsp70 disaggregase system. Brain. 2022 09 14; 145(9):3236-3249.
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Nalls AV, McNulty EE, Mayfield A, Crum JM, Keel MK, Hoover EA, Ruder MG, Mathiason CK. Detection of Chronic Wasting Disease Prions in Fetal Tissues of Free-Ranging White-Tailed Deer. Viruses. 2021 12 03; 13(12).
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Rovnak J, St Clair LA, McAlister C, Ogbu CP, Smolenske J, Cohrs RJ, Perera R. The 20th Anniversary Meeting of the Rocky Mountain Virology Association. Viruses. 2020 12 29; 13(1).
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Denkers ND, Hoover CE, Davenport KA, Henderson DM, McNulty EE, Nalls AV, Mathiason CK, Hoover EA. Very low oral exposure to prions of brain or saliva origin can transmit chronic wasting disease. PLoS One. 2020; 15(8):e0237410.
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