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Maggie PY Lam

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    R01HL169473     (LAU, EDWARD)Mar 1, 2024 - Feb 28, 2028
    NIH
    Extracellular matrix turnover in pathological cardiac remodeling
    Role: Co-Principal Investigator
    R01GM144456     (LAM, MAGGIE)Sep 20, 2022 - Jul 31, 2026
    NIH
    Post-transcriptional regulations of proteomes in stress and senescence
    Role: Principal Investigator
    R01GM144456     (LAM, MAGGIE)Sep 20, 2022 - Jul 31, 2026
    NIGMS
    Post-transcriptional regulations of proteomes in stress and senescence
    Role: Principal Investigator
    R21HL150456     (LAM, MAGGIE)Jan 15, 2020 - Dec 30, 2021
    NIH
    Recovering Proteoforms from Cardiovascular Omics Datasets: A Multi-omics Secondary Analysis
    Role: Principal Investigator
    R01HL141278     (LAM, MAGGIE)Jun 1, 2018 - Apr 30, 2027
    NIH
    Alternative Protein Isoforms in Ventricular Remodeling
    Role: Principal Investigator
    R00HL127302     (LAM, MAGGIE)Aug 1, 2017 - Jul 31, 2021
    NIH
    ER Stress and Protein Dynamics in Cardiac Remodeling
    Role: Principal Investigator
    K99HL127302     (LAM, MAGGIE)Jan 15, 2016 - Dec 31, 2017
    NIH
    ER Stress and Protein Dynamics in Cardiac Remodeling
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Currie J, Manda V, Robinson SK, Lai C, Agnihotri V, Hidalgo V, Ludwig RW, Zhang K, Pavelka J, Wang ZV, Rhee JW, Lam MPY, Lau E. Simultaneous proteome localization and turnover analysis reveals spatiotemporal features of protein homeostasis disruptions. bioRxiv. 2024 Jan 17. PMID: 36711879.
      View in: PubMed
    2. Pandi B, Brenman S, Black A, Ng DCM, Lau E, Lam MPY. Tissue Usage Preference and Intrinsically Disordered Region Remodeling of Alternative Splicing Derived Proteoforms in the Heart. bioRxiv. 2023 Oct 09. PMID: 37873130.
      View in: PubMed
    3. Hidalgo V, Kastury N, Durham CW, Currie J, Amaya M, Lam MPY, Lau E. Co-culture with normal and senescent AC16 cardiomyocytes modulates fibrotic response in primary human ventricular fibroblasts. MicroPubl Biol. 2023; 2023. PMID: 37456138.
      View in: PubMed
    4. Kastury N, Hidalgo V, Pandi B, Li L, Lam MPY, Lau E. Senescence in human AC16 cardiac cells is associated with thymidine kinase induction and histone loss. MicroPubl Biol. 2023; 2023. PMID: 37456137.
      View in: PubMed
    5. Lam MPY. Seeking clarity on sex differences in cardiovascular complications of Down syndrome. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H863-H865. PMID: 37115628.
      View in: PubMed
    6. Srivastava H, Lippincott MJ, Currie J, Canfield R, Lam MPY, Lau E. Protein prediction models support widespread post-transcriptional regulation of protein abundance by interacting partners. PLoS Comput Biol. 2022 11; 18(11):e1010702. PMID: 36356032.
      View in: PubMed
    7. Eaton DM, Berretta RM, Lynch JE, Travers JG, Pfeiffer RD, Hulke ML, Zhao H, Hobby ARH, Schena G, Johnson JP, Wallner M, Lau E, Lam MPY, Woulfe KC, Tucker NR, McKinsey TA, Wolfson MR, Houser SR. Sex-specific responses to slow progressive pressure overload in a large animal model of HFpEF. Am J Physiol Heart Circ Physiol. 2022 10 01; 323(4):H797-H817. PMID: 36053749.
      View in: PubMed
    8. Han Y, Wennersten SA, Wright JM, Ludwig RW, Lau E, Lam MPY. Proteogenomics reveals sex-biased aging genes and coordinated splicing in cardiac aging. Am J Physiol Heart Circ Physiol. 2022 09 01; 323(3):H538-H558. PMID: 35930447.
      View in: PubMed
    9. Lin YH, Major JL, Liebner T, Hourani Z, Travers JG, Wennersten SA, Haefner KR, Cavasin MA, Wilson CE, Jeong MY, Han Y, Gotthardt M, Ferguson SK, Ambardekar AV, Lam MP, Choudhary C, Granzier HL, Woulfe KC, McKinsey TA. HDAC6 modulates myofibril stiffness and diastolic function of the heart. J Clin Invest. 2022 05 16; 132(10). PMID: 35575093.
      View in: PubMed
    10. Han Y, Thomas CT, Wennersten SA, Lau E, Lam MPY. Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot. J Vis Exp. 2021 10 28; (176). PMID: 34779440.
      View in: PubMed
    11. Han Y, Li LZ, Kastury NL, Thomas CT, Lam MPY, Lau E. Transcriptome features of striated muscle aging and predictability of protein level changes. Mol Omics. 2021 10 11; 17(5):796-808. PMID: 34328155.
      View in: PubMed
    12. Chour T, Tian L, Lau E, Thomas D, Itzhaki I, Malak O, Zhang JZ, Qin X, Wardak M, Liu Y, Chandy M, Black KE, Lam MP, Neofytou E, Wu JC. Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies. JCI Insight. 2021 04 08; 6(7). PMID: 33830086.
      View in: PubMed
    13. Travers JG, Wennersten SA, Pe?a B, Bagchi RA, Smith HE, Hirsch RA, Vanderlinden LA, Lin YH, Dobrinskikh E, Demos-Davies KM, Cavasin MA, Mestroni L, Steink?hler C, Lin CY, Houser SR, Woulfe KC, Lam MPY, McKinsey TA. HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling. Circulation. 2021 05 11; 143(19):1874-1890. PMID: 33682427.
      View in: PubMed
    14. Han Y, Wood SD, Wright JM, Dostal V, Lau E, Lam MPY. Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart. J Mol Cell Cardiol. 2021 05; 154:92-96. PMID: 33549679.
      View in: PubMed
    15. Dostal V, Wood SD, Thomas CT, Han Y, Lau E, Lam MPY. Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart. Sci Rep. 2020 10 28; 10(1):18440. PMID: 33116222.
      View in: PubMed
    16. Adhikari S, Nice EC, Deutsch EW, Lane L, Omenn GS, Pennington SR, Paik YK, Overall CM, Corrales FJ, Cristea IM, Van Eyk JE, Uhl?n M, Lindskog C, Chan DW, Bairoch A, Waddington JC, Justice JL, LaBaer J, Rodriguez H, He F, Kostrzewa M, Ping P, Gundry RL, Stewart P, Srivastava S, Srivastava S, Nogueira FCS, Domont GB, Vandenbrouck Y, Lam MPY, Wennersten S, Vizcaino JA, Wilkins M, Schwenk JM, Lundberg E, Bandeira N, Marko-Varga G, Weintraub ST, Pineau C, Kusebauch U, Moritz RL, Ahn SB, Palmblad M, Snyder MP, Aebersold R, Baker MS. A high-stringency blueprint of the human proteome. Nat Commun. 2020 10 16; 11(1):5301. PMID: 33067450.
      View in: PubMed
    17. Han Y, Wennersten SA, Lam MPY. Working the literature harder: what can text mining and bibliometric analysis reveal? Expert Rev Proteomics. 2019 Nov - Dec; 16(11-12):871-873. PMID: 31822126.
      View in: PubMed
    18. Lau E, Han Y, Williams DR, Thomas CT, Shrestha R, Wu JC, Lam MPY. Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome. Cell Rep. 2019 12 10; 29(11):3751-3765.e5. PMID: 31825849.
      View in: PubMed
    19. Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MPY, Haldar SM, Lin CY, McKinsey TA. Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation. Circ Res. 2019 09 13; 125(7):662-677. PMID: 31409188.
      View in: PubMed
    20. Lau E, Venkatraman V, Thomas CT, Wu JC, Van Eyk JE, Lam MPY. Identifying High-Priority Proteins Across the Human Diseasome Using Semantic Similarity. J Proteome Res. 2018 12 07; 17(12):4267-4278. PMID: 30256117.
      View in: PubMed
    21. Lam MPY, Ge Y. Harnessing the Power of Proteomics to Assess Drug Safety and Guide Clinical Trials. Circulation. 2018 03 06; 137(10):1011-1014. PMID: 29506994.
      View in: PubMed
    22. Lau E, Cao Q, Lam MPY, Wang J, Ng DCM, Bleakley BJ, Lee JM, Liem DA, Wang D, Hermjakob H, Ping P. Integrated omics dissection of proteome dynamics during cardiac remodeling. Nat Commun. 2018 01 09; 9(1):120. PMID: 29317621.
      View in: PubMed
    23. Lam MP, Ping P, Murphy E. Proteomics Research in Cardiovascular Medicine and Biomarker Discovery. J Am Coll Cardiol. 2016 Dec 27; 68(25):2819-2830. PMID: 28007144.
      View in: PubMed
    24. Lam MP, Lau E, Ng DC, Wang D, Ping P. Cardiovascular proteomics in the era of big data: experimental and computational advances. Clin Proteomics. 2016; 13:23. PMID: 27980500.
      View in: PubMed
    25. Lam MP, Venkatraman V, Xing Y, Lau E, Cao Q, Ng DC, Su AI, Ge J, Van Eyk JE, Ping P. Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems. J Proteome Res. 2016 11 04; 15(11):4126-4134. PMID: 27356587.
      View in: PubMed
    26. Lau E, Cao Q, Ng DC, Bleakley BJ, Dincer TU, Bot BM, Wang D, Liem DA, Lam MP, Ge J, Ping P. A large dataset of protein dynamics in the mammalian heart proteome. Sci Data. 2016 Mar 15; 3:160015. PMID: 26977904.
      View in: PubMed
    27. Lin L, Jiang P, Park JW, Wang J, Lu ZX, Lam MP, Ping P, Xing Y. The contribution of Alu exons to the human proteome. Genome Biol. 2016 Jan 28; 17:15. PMID: 26821878.
      View in: PubMed
    28. Semba RD, Lam M, Sun K, Zhang P, Schaumberg DA, Ferrucci L, Ping P, Van Eyk JE. Priorities and trends in the study of proteins in eye research, 1924-2014. Proteomics Clin Appl. 2015 Dec; 9(11-12):1105-22. PMID: 26123431.
      View in: PubMed
    29. Lam MP, Venkatraman V, Cao Q, Wang D, Dincer TU, Lau E, Su AI, Xing Y, Ge J, Ping P, Van Eyk JE. Prioritizing Proteomics Assay Development for Clinical Translation. J Am Coll Cardiol. 2015 Jul 14; 66(2):202-4. PMID: 26160638.
      View in: PubMed
    30. Lau E, Huang D, Cao Q, Dincer TU, Black CM, Lin AJ, Lee JM, Wang D, Liem DA, Lam MP, Ping P. Spatial and temporal dynamics of the cardiac mitochondrial proteome. Expert Rev Proteomics. 2015 Apr; 12(2):133-46. PMID: 25752359.
      View in: PubMed
    31. Zong N, Ping P, Lau E, Choi HJ, Ng DC, Meyer D, Fang C, Li H, Wang D, Zelaya IM, Yates JR, Lam MP. Lysine ubiquitination and acetylation of human cardiac 20S proteasomes. Proteomics Clin Appl. 2014 Aug; 8(7-8):590-594. PMID: 24957502.
      View in: PubMed
    32. Wang D, Liem DA, Lau E, Ng DC, Bleakley BJ, Cadeiras M, Deng MC, Lam MP, Ping P. Characterization of human plasma proteome dynamics using deuterium oxide. Proteomics Clin Appl. 2014 Aug; 8(7-8):610-9. PMID: 24946186.
      View in: PubMed
    33. Lam MP, Wang D, Lau E, Liem DA, Kim AK, Ng DC, Liang X, Bleakley BJ, Liu C, Tabaraki JD, Cadeiras M, Wang Y, Deng MC, Ping P. Protein kinetic signatures of the remodeling heart following isoproterenol stimulation. J Clin Invest. 2014 Apr; 124(4):1734-44. PMID: 24614109.
      View in: PubMed
    34. Lam MP, Lau E, Liem DA, Ping P. Cyclophilin D and acetylation: a new link in cardiac signaling. Circ Res. 2013 Dec 06; 113(12):1268-9. PMID: 24311610.
      View in: PubMed
    35. Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P. Integration of cardiac proteome biology and medicine by a specialized knowledgebase. Circ Res. 2013 Oct 12; 113(9):1043-53. PMID: 23965338.
      View in: PubMed
    36. Li H, Zong NC, Liang X, Kim AK, Choi JH, Deng N, Zelaya I, Lam M, Duan H, Ping P. A novel spectral library workflow to enhance protein identifications. J Proteomics. 2013 Apr 09; 81:173-84. PMID: 23391412.
      View in: PubMed
    37. Lam MP, Lau E, Scruggs SB, Wang D, Kim TY, Liem DA, Zhang J, Ryan CM, Faull KF, Ping P. Site-specific quantitative analysis of cardiac mitochondrial protein phosphorylation. J Proteomics. 2013 Apr 09; 81:15-23. PMID: 23022582.
      View in: PubMed
    38. Kim TY, Wang D, Kim AK, Lau E, Lin AJ, Liem DA, Zhang J, Zong NC, Lam MP, Ping P. Metabolic labeling reveals proteome dynamics of mouse mitochondria. Mol Cell Proteomics. 2012 Dec; 11(12):1586-94. PMID: 22915825.
      View in: PubMed
    39. Zhang J, Lin A, Powers J, Lam MP, Lotz C, Liem D, Lau E, Wang D, Deng N, Korge P, Zong NC, Cai H, Weiss J, Ping P. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation. J Gen Physiol. 2012 Jun; 139(6):395-406. PMID: 22641634.
      View in: PubMed
    40. Lau E, Wang D, Zhang J, Yu H, Lam MP, Liang X, Zong N, Kim TY, Ping P. Substrate- and isoform-specific proteome stability in normal and stressed cardiac mitochondria. Circ Res. 2012 Apr 27; 110(9):1174-8. PMID: 22456183.
      View in: PubMed
    41. Lam MP, Vivanco F, Scholten A, Hermjakob H, Van Eyk J, Ping P. HUPO 2011: The new Cardiovascular Initiative - integrating proteomics and cardiovascular biology in health and disease. Proteomics. 2012 Mar; 12(6):749-51. PMID: 22539426.
      View in: PubMed
    42. Lam MP, Scruggs SB, Kim TY, Zong C, Lau E, Wang D, Ryan CM, Faull KF, Ping P. An MRM-based workflow for quantifying cardiac mitochondrial protein phosphorylation in murine and human tissue. J Proteomics. 2012 Aug 03; 75(15):4602-9. PMID: 22387130.
      View in: PubMed
    43. Lam MP, Lau E, Siu SO, Ng DC, Kong RP, Chiu PC, Yeung WS, Lo C, Chu IK. Online combination of reversed-phase/reversed-phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples. Electrophoresis. 2011 Nov; 32(21):2930-40. PMID: 22009802.
      View in: PubMed
    44. Siu SO, Lam MP, Lau E, Kong RP, Lee SM, Chu IK. Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics. Proteomics. 2011 Jun; 11(11):2308-19. PMID: 21548098.
      View in: PubMed
    45. Lau E, Lam MP, Siu SO, Kong RP, Chan WL, Zhou Z, Huang J, Lo C, Chu IK. Combinatorial use of offline SCX and online RP-RP liquid chromatography for iTRAQ-based quantitative proteomics applications. Mol Biosyst. 2011 May; 7(5):1399-408. PMID: 21350782.
      View in: PubMed
    46. Lam MP, Siu SO, Lau E, Mao X, Sun HZ, Chiu PC, Yeung WS, Cox DM, Chu IK. Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization. Anal Bioanal Chem. 2010 Sep; 398(2):791-804. PMID: 20632160.
      View in: PubMed
    47. Liu H, Lau E, Lam MPY, Chu H, Li S, Huang G, Guo P, Wang J, Jiang L, Chu IK, Lo C, Tao Y. OsNOA1/RIF1 is a functional homolog of AtNOA1/RIF1: implication for a highly conserved plant cGTPase essential for chloroplast function. New Phytol. 2010 Jul; 187(1):83-105. PMID: 20456051.
      View in: PubMed
    48. Siu SO, Lam MP, Lau E, Yeung WS, Cox DM, Chu IK. N-linked glycoprotein analysis using dual-extraction ultrahigh-performance liquid chromatography and electrospray tandem mass spectrometry. Methods Mol Biol. 2010; 600:133-43. PMID: 19882125.
      View in: PubMed
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