 Aprotinin
"Aprotinin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
| Descriptor ID |
D007611
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| MeSH Number(s) |
D12.776.083
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| Concept/Terms |
Aprotinin- Aprotinin
- Trypsin Inhibitor, Basic, Pancreatic
- Bovine Kunitz Pancreatic Trypsin Inhibitor
- BPTI, Basic Pancreatic Trypsin Inhibitor
- Kallikrein-Trypsin Inactivator
- Inactivator, Kallikrein-Trypsin
- Kallikrein Trypsin Inactivator
- Kunitz Pancreatic Trypsin Inhibitor
- Trypsin Inhibitor, Kunitz, Pancreatic
- Basic Pancreatic Trypsin Inhibitor
- Bovine Pancreatic Trypsin Inhibitor
Contrykal- Contrykal
- Kontrykal
- Kontrikal
- Contrical
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Below are MeSH descriptors whose meaning is more general than "Aprotinin".
Below are MeSH descriptors whose meaning is more specific than "Aprotinin".
This graph shows the total number of publications written about "Aprotinin" by people in this website by year, and whether "Aprotinin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 0 | 2 | | 1997 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2006 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "Aprotinin" by people in Profiles.
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Murata H, Cummings CS, Koepsel RR, Russell AJ. Rational tailoring of substrate and inhibitor affinity via ATRP polymer-based protein engineering. Biomacromolecules. 2014 Jul 14; 15(7):2817-23.
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Dai SX, Zhang AD, Huang JF. Evolution, expansion and expression of the Kunitz/BPTI gene family associated with long-term blood feeding in Ixodes Scapularis. BMC Evol Biol. 2012 Jan 14; 12:4.
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Pasquali SK, Hall M, Li JS, Peterson ED, Jaggers J, Lodge AJ, Jacobs JP, Jacobs ML, Shah SS. Safety of aprotinin in congenital heart operations: results from a large multicenter database. Ann Thorac Surg. 2010 Jul; 90(1):14-21.
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Twite MD, Hammer GB. The use of aprotinin in pediatric cardiac surgery: should we bid 'good riddance' or are we throwing out the baby with the bath water? Paediatr Anaesth. 2008 Sep; 18(9):809-11.
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Hiatt WR. Observational studies of drug safety--aprotinin and the absence of transparency. N Engl J Med. 2006 Nov 23; 355(21):2171-3.
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Hanson WM, Domek GJ, Horvath MP, Goldenberg DP. Rigidification of a flexible protease inhibitor variant upon binding to trypsin. J Mol Biol. 2007 Feb 09; 366(1):230-43.
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Jaggers J, Lawson JH. Coagulopathy and inflammation in neonatal heart surgery: mechanisms and strategies. Ann Thorac Surg. 2006 Jun; 81(6):S2360-6.
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Coughlan CM, Walker JL, Cochran JC, Wittrup KD, Brodsky JL. Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control. J Biol Chem. 2004 Apr 09; 279(15):15289-97.
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Goldstein DJ, DeRosa CM, Seldomridge JA, Weinberg AD, Oz MC, Smith CR. Is aprotinin indicated for reoperative valvular surgery? J Heart Valve Dis. 1997 Jan; 6(1):88-92.
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Goldstein DJ, DeRosa CM, Mongero LB, Weinberg AD, Michler RE, Rose EA, Oz MC, Smith CR. Safety and efficacy of aprotinin under conditions of deep hypothermia and circulatory arrest. J Thorac Cardiovasc Surg. 1995 Dec; 110(6):1615-21; discussion 1621-2.
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