 Histones
"Histones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
| Descriptor ID |
D006657
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| MeSH Number(s) |
D12.776.157.687.485 D12.776.660.720.485 D12.776.664.469
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Histones".
Below are MeSH descriptors whose meaning is more specific than "Histones".
This graph shows the total number of publications written about "Histones" by people in this website by year, and whether "Histones" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 2 | 0 | 2 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 3 | 3 | | 2001 | 2 | 6 | 8 | | 2002 | 1 | 2 | 3 | | 2003 | 5 | 0 | 5 | | 2004 | 5 | 2 | 7 | | 2005 | 6 | 2 | 8 | | 2006 | 9 | 5 | 14 | | 2007 | 4 | 5 | 9 | | 2008 | 7 | 6 | 13 | | 2009 | 11 | 4 | 15 | | 2010 | 5 | 9 | 14 | | 2011 | 8 | 10 | 18 | | 2012 | 15 | 11 | 26 | | 2013 | 10 | 12 | 22 | | 2014 | 8 | 13 | 21 | | 2015 | 4 | 18 | 22 | | 2016 | 18 | 13 | 31 | | 2017 | 21 | 6 | 27 | | 2018 | 17 | 10 | 27 | | 2019 | 14 | 13 | 27 | | 2020 | 11 | 20 | 31 | | 2021 | 15 | 12 | 27 | | 2022 | 10 | 10 | 20 | | 2023 | 15 | 11 | 26 | | 2024 | 14 | 5 | 19 | | 2025 | 9 | 6 | 15 | | 2026 | 1 | 2 | 3 |
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Below are the most recent publications written about "Histones" by people in Profiles.
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Zych MG, Contreras M, Mammel AE, Hatch EM. RCC1 depletion drives protein transport defects and rupture in micronuclei. J Cell Biol. 2026 Apr 06; 225(4).
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Bai X, Zhang J, Wang S, Huang K, Pan Z, Liang A, Wu W, Yu Z, Chen Y, Tong Y, Dai S, Chen Z. Novel intermolecular zinc fingers and redox-driven conformational changes dictate tumor suppressor ZMYND11's role in cooperative recognition of diverse targets. Nucleic Acids Res. 2026 Jan 22; 54(3).
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Fuchs HA, Peng Y, Ayyapan S, Rosas R, Zhang H, Panchenko AR, Musselman CA. G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails. Nucleic Acids Res. 2026 Jan 14; 54(2).
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Rudolph J, Luger K. Histone PARylation factor 1: a review of its role in the DNA damage response. Nucleic Acids Res. 2025 Oct 28; 53(20).
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Locke RC, Miller LM, Lemmon EA, Assi SS, Jones DL, Bonnevie ED, Burdick JA, Heo SJ, Mauck RL. Rapid restoration of cell phenotype and matrix forming capacity following transient nuclear softening. Acta Biomater. 2025 Dec; 208:336-349.
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Lamolinara A, Di Lisio C, Hixon JA, Simeone P, De Cola A, Falco MD, Meyer TJ, Ferrone A, Genovesi D, Lanuti P, Li W, De Laurenzi V, Iezzi M, Aiello FB, Durum SK. IL-7 promotes the formation of DNA double strand breaks and DNA repair in murine pro-B cells. Front Immunol. 2025; 16:1633892.
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Warmke LM, Davis JL, Al-Ibraheemi A, Arnold M, Tan S, Shenoy A, Surrey LF, Parham DM, Rudzinski ER. Loss of H3K27me3 Is Not Specific to Malignant Triton Tumor: Immunohistochemical Analysis of 23 Cases of Embryonal Rhabdomyosarcoma. Arch Pathol Lab Med. 2025 Oct 01; 149(10):944-949.
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Guo Y, Li Z, Parsels LA, Wang Z, Parsels JD, Dalvi A, The S, Hu N, Valvo VM, Doherty R, Peterson E, Wang X, Venkataraman S, Agnihotri S, Venneti S, Wahl DR, Green MD, Lawrence TS, Koschmann C, Morgan MA, Zhang Q. H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition. Neuro Oncol. 2025 Sep 17; 27(8):2129-2146.
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Villalta A, Bisio H, Toner CM, Abergel C, Luger K. Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures. Nat Commun. 2025 Jul 26; 16(1):6903.
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Becht DC, Biswas S, Xu C, Xuan H, Khalil M, Cai L, Musselman CA, Liu X, Affar EB, Shi X, Wang GG, Kutateladze TG. Multiple transactivation domains of EZH2 bind to the TAZ2 domain of p300 and stimulate the acetyltransferase function of p300. Biochem J. 2025 Jul 02; 482(13):955-968.
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