 Histones
"Histones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
| Descriptor ID |
D006657
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| MeSH Number(s) |
D12.776.157.687.485 D12.776.660.720.485 D12.776.664.469
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Histones".
Below are MeSH descriptors whose meaning is more specific than "Histones".
This graph shows the total number of publications written about "Histones" by people in this website by year, and whether "Histones" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 | | 1994 | 1 | 0 | 1 | | 1998 | 2 | 0 | 2 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 3 | 3 | | 2001 | 2 | 6 | 8 | | 2002 | 1 | 2 | 3 | | 2003 | 4 | 0 | 4 | | 2004 | 5 | 3 | 8 | | 2005 | 8 | 1 | 9 | | 2006 | 8 | 5 | 13 | | 2007 | 4 | 5 | 9 | | 2008 | 6 | 6 | 12 | | 2009 | 10 | 6 | 16 | | 2010 | 5 | 12 | 17 | | 2011 | 9 | 10 | 19 | | 2012 | 15 | 10 | 25 | | 2013 | 9 | 11 | 20 | | 2014 | 9 | 14 | 23 | | 2015 | 3 | 13 | 16 | | 2016 | 16 | 15 | 31 | | 2017 | 20 | 7 | 27 | | 2018 | 16 | 9 | 25 | | 2019 | 14 | 13 | 27 | | 2020 | 9 | 19 | 28 | | 2021 | 12 | 11 | 23 | | 2022 | 2 | 3 | 5 |
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Below are the most recent publications written about "Histones" by people in Profiles.
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Sharma S, Yang IV, Schwartz DA. Epigenetic regulation of immune function in asthma. J Allergy Clin Immunol. 2022 08; 150(2):259-265.
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Kusuyama J, Makarewicz NS, Albertson BG, Alves-Wagner AB, Conlin RH, Prince NB, Alves CRR, Ramachandran K, Kozuka C, Xiudong Y, Xia Y, Hirshman MF, Hatta T, Nagatomi R, Nozik ES, Goodyear LJ. Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High-Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation. Diabetes. 2022 06 01; 71(6):1170-1181.
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Kraft K, Yost KE, Murphy SE, Magg A, Long Y, Corces MR, Granja JM, Wittler L, Mundlos S, Cech TR, Boettiger AN, Chang HY. Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2201883119.
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Bosire R, Fadel L, Mocsár G, Nánási P, Sen P, Sharma AK, Naseem MU, Kovács A, Kugel J, Kroemer G, Vámosi G, Szabó G. Doxorubicin impacts chromatin binding of HMGB1, Histone H1 and retinoic acid receptor. Sci Rep. 2022 05 16; 12(1):8087.
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Diamond JR, Pitts TM, Ungermannova D, Nasveschuk CG, Zhang G, Phillips AJ, Bagby SM, Pafford J, Yacob BW, Newton TP, Tentler JJ, Gittleman B, Hartman SJ, DeMattei JA, Winkler JD, Wendt MK, Schiemann WP, Eckhardt SG, Liu X, Piscopio AD. Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors. Mol Cancer Ther. 2022 03 01; 21(3):397-406.
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Porazzi P, Petruk S, Pagliaroli L, De Dominici M, Deming D, Puccetti MV, Kushinsky S, Kumar G, Minieri V, Barbieri E, Deliard S, Grande A, Trizzino M, Gardini A, Canaani E, Palmisiano N, Porcu P, Ertel A, Fortina P, Eischen CM, Mazo A, Calabretta B. Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression. Cancer Res. 2022 02 01; 82(3):458-471.
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Bouchard BA, Colovos C, Lawson MA, Osborn ZT, Sackheim AM, Mould KJ, Janssen WJ, Cohen MJ, Majumdar D, Freeman K. Increased histone-DNA complexes and endothelial-dependent thrombin generation in severe COVID-19. Vascul Pharmacol. 2022 02; 142:106950.
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Andergassen D, Smith ZD, Kretzmer H, Rinn JL, Meissner A. Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages. Dev Cell. 2021 11 08; 56(21):2995-3005.e4.
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Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chem Biol. 2022 04 21; 29(4):555-571.e11.
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Vann KR, Vishweshwaraiah YL, Dokholyan NV, Kutateladze TG. Searching for methyllysine-binding aromatic cages. Biochem J. 2021 10 15; 478(19):3613-3619.
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