 Histones
"Histones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
| Descriptor ID |
D006657
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| MeSH Number(s) |
D12.776.157.687.485 D12.776.660.720.485 D12.776.664.469
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Histones".
Below are MeSH descriptors whose meaning is more specific than "Histones".
This graph shows the total number of publications written about "Histones" by people in this website by year, and whether "Histones" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 1 | 1 | 2 | | 1993 | 0 | 1 | 1 | | 1994 | 1 | 0 | 1 | | 1998 | 2 | 0 | 2 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 3 | 3 | | 2001 | 2 | 6 | 8 | | 2002 | 1 | 2 | 3 | | 2003 | 4 | 2 | 6 | | 2004 | 7 | 2 | 9 | | 2005 | 9 | 2 | 11 | | 2006 | 9 | 6 | 15 | | 2007 | 4 | 7 | 11 | | 2008 | 7 | 7 | 14 | | 2009 | 11 | 4 | 15 | | 2010 | 6 | 10 | 16 | | 2011 | 10 | 12 | 22 | | 2012 | 15 | 13 | 28 | | 2013 | 10 | 11 | 21 | | 2014 | 11 | 16 | 27 | | 2015 | 3 | 13 | 16 | | 2016 | 18 | 15 | 33 | | 2017 | 20 | 7 | 27 | | 2018 | 15 | 7 | 22 | | 2019 | 13 | 9 | 22 | | 2020 | 2 | 3 | 5 |
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Below are the most recent publications written about "Histones" by people in Profiles.
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Zhang Y, Guo Y, Gough SM, Zhang J, Vann KR, Li K, Cai L, Shi X, Aplan PD, Wang GG, Kutateladze TG. Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun. 2020 07 03; 11(1):3339.
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Rudolph J, Luger K. The secret life of histones. Science. 2020 07 03; 369(6499):33.
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Bacon CW, Challa A, Hyder U, Shukla A, Borkar AN, Bayo J, Liu J, Wu SY, Chiang CM, Kutateladze TG, D'Orso I. KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs. Mol Cell. 2020 06 18; 78(6):1133-1151.e14.
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Liu H, Lee S, Zhang Q, Chen Z, Zhang G. The potential underlying mechanism of the leukemia caused by MLL-fusion and potential treatments. Mol Carcinog. 2020 07; 59(7):839-851.
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Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski JA, Galligan JJ, Fritz K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGFß2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3. Biochem J. 2020 01 17; 477(1):75-97.
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Goswami DG, Kant R, Ammar DA, Agarwal C, Gomez J, Agarwal R, Saba LM, Fritz KS, Tewari-Singh N. Toxic consequences and oxidative protein carbonylation from chloropicrin exposure in human corneal epithelial cells. Toxicol Lett. 2020 Apr 01; 322:1-11.
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Mondal P, Sen S, Klein BJ, Tiwary N, Gadad SS, Kutateladze TG, Roy S, Das C. TCF19 Promotes Cell Proliferation through Binding to the Histone H3K4me3 Mark. Biochemistry. 2020 02 04; 59(4):389-399.
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Zhang Y, Kutateladze TG. Liquid-liquid phase separation is an intrinsic physicochemical property of chromatin. Nat Struct Mol Biol. 2019 12; 26(12):1085-1086.
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Watson ZL, Yamamoto TM, McMellen A, Kim H, Hughes CJ, Wheeler LJ, Post MD, Behbakht K, Bitler BG. Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma. Clin Epigenetics. 2019 11 27; 11(1):165.
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Klein BJ, Cox KL, Jang SM, Côté J, Poirier MG, Kutateladze TG. Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin. Structure. 2020 01 07; 28(1):105-110.e3.
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