 Triggering Receptor Expressed on Myeloid Cells-1
"Triggering Receptor Expressed on Myeloid Cells-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An approximately 230 amino acid membrane glycoprotein characterized by an IMMUNOGLOBULIN V-SET DOMAIN in its N-terminal half. It is expressed by MONOCYTES and NEUTROPHILS in response to INFLAMMATION related to bacterial and fungal infections. It triggers the release of pro-inflammatory CHEMOKINES; CYTOKINES, and expression of cell activation markers and is a critical regulator of SEPTIC SHOCK.
| Descriptor ID |
D000073871
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| MeSH Number(s) |
D12.776.395.550.919 D12.776.543.550.919 D12.776.543.750.705.985
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Triggering Receptor Expressed on Myeloid Cells-1".
Below are MeSH descriptors whose meaning is more specific than "Triggering Receptor Expressed on Myeloid Cells-1".
This graph shows the total number of publications written about "Triggering Receptor Expressed on Myeloid Cells-1" by people in this website by year, and whether "Triggering Receptor Expressed on Myeloid Cells-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2006 | 0 | 2 | 2 | | 2011 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Triggering Receptor Expressed on Myeloid Cells-1" by people in Profiles.
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Terada Y, Li W, Amrute JM, Bery AI, Liu CR, Nunna V, Frye CC, Dun H, Koenig AL, Luehmann HP, Heo GS, Owen MC, Wein AN, Liu Y, Ritter JH, Prabhu SD, Nava RG, Gelman AE, Cella M, Colonna M, Lavine KJ, Kreisel D. Tissue-resident CCR2+ macrophage TREM-1/3 signaling is necessary for monocyte and neutrophil recruitment to injured hearts. Cell Rep. 2025 Mar 25; 44(3):115380.
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Tyler PM, Bucklin ML, Zhao M, Maher TJ, Rice AJ, Ji W, Warner N, Pan J, Morotti R, McCarthy P, Griffiths A, van Rossum AMC, Hollink IHIM, Dalm VASH, Catanzaro J, Lakhani SA, Muise AM, Lucas CL. Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation. Nat Immunol. 2021 09; 22(9):1118-1126.
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Ohlstrom D, Hernandez-Lagunas L, Garcia AM, Allawzi A, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. MicroRNA regulation postbleomycin due to the R213G extracellular superoxide dismutase variant is predicted to suppress inflammatory and immune pathways. Physiol Genomics. 2020 06 01; 52(6):245-254.
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Arts RJ, Joosten LA, Dinarello CA, Kullberg BJ, van der Meer JW, Netea MG. TREM-1 interaction with the LPS/TLR4 receptor complex. Eur Cytokine Netw. 2011 Mar; 22(1):11-4.
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Netea MG, Azam T, Ferwerda G, Girardin SE, Kim SH, Dinarello CA. Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors. J Leukoc Biol. 2006 Dec; 80(6):1454-61.
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Mohamadzadeh M, Coberley SS, Olinger GG, Kalina WV, Ruthel G, Fuller CL, Swenson DL, Pratt WD, Kuhns DB, Schmaljohn AL. Activation of triggering receptor expressed on myeloid cells-1 on human neutrophils by marburg and ebola viruses. J Virol. 2006 Jul; 80(14):7235-44.
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