Histocompatibility Antigens Class II
"Histocompatibility Antigens Class II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Descriptor ID |
D000949
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MeSH Number(s) |
D12.776.395.550.509 D12.776.543.550.440 D23.050.301.500.400 D23.050.705.552.410
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Concept/Terms |
Histocompatibility Antigens Class II- Histocompatibility Antigens Class II
- Class II Antigens
- Antigens, Class II
- Class II Histocompatibility Antigens
- Ia-Like Antigens
- Antigens, Ia-Like
- Ia Like Antigens
- IA Antigen
- Antigen, IA
- I-A Antigen
- Antigen, I-A
- Antigens, Immune Response
- Immune Response Antigens
- Immune-Response-Associated Antigens
- Antigens, Immune-Response-Associated
- Immune Response Associated Antigens
- Class II Major Histocompatibility Antigens
- I-A-Antigen
- I A Antigen
- Class II Antigen
- Antigen, Class II
- Ia Antigens
- Antigens, Ia
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Below are MeSH descriptors whose meaning is more general than "Histocompatibility Antigens Class II".
Below are MeSH descriptors whose meaning is more specific than "Histocompatibility Antigens Class II".
This graph shows the total number of publications written about "Histocompatibility Antigens Class II" by people in this website by year, and whether "Histocompatibility Antigens Class II" was a major or minor topic of these publications.
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1995 | 2 | 1 | 3 | 1996 | 3 | 3 | 6 | 1997 | 2 | 2 | 4 | 1998 | 4 | 2 | 6 | 1999 | 3 | 5 | 8 | 2000 | 0 | 3 | 3 | 2001 | 3 | 2 | 5 | 2002 | 3 | 3 | 6 | 2003 | 4 | 6 | 10 | 2004 | 2 | 5 | 7 | 2005 | 1 | 3 | 4 | 2006 | 1 | 1 | 2 | 2007 | 2 | 0 | 2 | 2008 | 2 | 2 | 4 | 2009 | 1 | 2 | 3 | 2010 | 2 | 4 | 6 | 2011 | 7 | 3 | 10 | 2012 | 4 | 4 | 8 | 2013 | 4 | 6 | 10 | 2014 | 3 | 1 | 4 | 2015 | 2 | 4 | 6 | 2016 | 4 | 1 | 5 | 2017 | 2 | 1 | 3 | 2018 | 0 | 3 | 3 | 2019 | 3 | 1 | 4 | 2020 | 2 | 3 | 5 | 2021 | 0 | 3 | 3 | 2022 | 0 | 3 | 3 | 2023 | 1 | 0 | 1 | 2024 | 2 | 0 | 2 |
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Below are the most recent publications written about "Histocompatibility Antigens Class II" by people in Profiles.
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Schuetze KB, Stratton MS, Bagchi RA, Hobby ARH, Felisbino MB, Rubino M, Toni LS, Reges C, Cavasin MA, McMahan RH, Alexanian M, Vagnozzi RJ, McKinsey TA. BRD4 inhibition rewires cardiac macrophages toward a protective phenotype marked by low MHC class II expression. Am J Physiol Heart Circ Physiol. 2025 Feb 01; 328(2):H294-H309.
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Iannucci J, Dominy R, Bandopadhyay S, Arthur EM, Noarbe B, Jullienne A, Krkasharyan M, Tobin RP, Pereverzev A, Beevers S, Venkatasamy L, Souza KA, Jupiter DC, Dabney A, Obenaus A, Newell-Rogers MK, Shapiro LA. Traumatic brain injury alters the effects of class II invariant peptide (CLIP) antagonism on chronic meningeal CLIP?+?B cells, neuropathology, and neurobehavioral impairment in 5xFAD mice. J Neuroinflammation. 2024 Jun 27; 21(1):165.
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Houwaart T, Scholz S, Pollock NR, Palmer WH, Kichula KM, Strelow D, Le DB, Belick D, H?lse L, Lautwein T, Wachtmeister T, Wollenweber TE, Henrich B, K?hrer K, Parham P, Guethlein LA, Norman PJ, Dilthey AT. Complete sequences of six major histocompatibility complex haplotypes, including all the major MHC class II structures. HLA. 2023 07; 102(1):28-43.
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Li W, Zhang Y, Li R, Wang Y, Chen L, Dai S. A Novel Tolerogenic Antibody Targeting Disulfide-Modified Autoantigen Effectively Prevents Type 1 Diabetes in NOD Mice. Front Immunol. 2022; 13:877022.
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Roark CL, Ho BE, Aubrey MT, Anobile C, Israeli S, Phang TL, Braxton D, Ho AP, Freed BM. HLA homozygosity is associated with Non-Hodgkin lymphoma. Hum Immunol. 2022 Oct; 83(10):730-735.
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Schriek P, Ching AC, Moily NS, Moffat J, Beattie L, Steiner TM, Hosking LM, Thurman JM, Holers VM, Ishido S, Lahoud MH, Caminschi I, Heath WR, Mintern JD, Villadangos JA. Marginal zone B cells acquire dendritic cell functions by trogocytosis. Science. 2022 02 11; 375(6581):eabf7470.
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Parras D, Sol? P, Delong T, Santamar?a P, Serra P. Recognition of Multiple Hybrid Insulin Peptides by a Single Highly Diabetogenic T-Cell Receptor. Front Immunol. 2021; 12:737428.
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Reed BK, Kappler JW. Hidden in Plain View: Discovery of Chimeric Diabetogenic CD4 T Cell Neo-Epitopes. Front Immunol. 2021; 12:669986.
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Reed B, Crawford F, Hill RC, Jin N, White J, Krovi SH, Marrack P, Hansen K, Kappler JW. Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation. J Exp Med. 2021 02 01; 218(2).
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Genardi S, Visvabharathy L, Cao L, Morgun E, Cui Y, Qi C, Chen YH, Gapin L, Berdyshev E, Wang CR. Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection. Front Immunol. 2020; 11:610010.
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