 Positive Transcriptional Elongation Factor B
"Positive Transcriptional Elongation Factor B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional elongation factor complex that is comprised of a heterodimer of CYCLIN-DEPENDENT KINASE 9 and one of several CYCLINS including TYPE T CYCLINS and cyclin K. It functions by phosphorylating the carboxy-terminal domain of RNA POLYMERASE II.
| Descriptor ID |
D042925
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| MeSH Number(s) |
D08.811.913.696.620.682.700.626 D12.776.930.955.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Positive Transcriptional Elongation Factor B".
Below are MeSH descriptors whose meaning is more specific than "Positive Transcriptional Elongation Factor B".
This graph shows the total number of publications written about "Positive Transcriptional Elongation Factor B" by people in this website by year, and whether "Positive Transcriptional Elongation Factor B" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2001 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2014 | 0 | 2 | 2 | | 2017 | 0 | 1 | 1 | | 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Positive Transcriptional Elongation Factor B" by people in Profiles.
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Liu H, Ramachandran S, Fong N, Phang T, Lee S, Parsa P, Liu X, Harmacek L, Danhorn T, Song T, Oh S, Zhang Q, Chen Z, Zhang Q, Tu TH, Happoldt C, O'Conner B, Janknecht R, Li CY, Marrack P, Kappler J, Leach S, Zhang G. JMJD5 couples with CDK9 to release the paused RNA polymerase II. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):19888-19895.
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Lee S, Liu H, Hill R, Chen C, Hong X, Crawford F, Kingsley M, Zhang Q, Liu X, Chen Z, Lengeling A, Bernt KM, Marrack P, Kappler J, Zhou Q, Li CY, Xue Y, Hansen K, Zhang G. JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes. Elife. 2020 02 12; 9.
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Ebmeier CC, Erickson B, Allen BL, Allen MA, Kim H, Fong N, Jacobsen JR, Liang K, Shilatifard A, Dowell RD, Old WM, Bentley DL, Taatjes DJ. Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications. Cell Rep. 2017 08 01; 20(5):1173-1186.
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Haldar SM, McKinsey TA. BET-ting on chromatin-based therapeutics for heart failure. J Mol Cell Cardiol. 2014 Sep; 74:98-102.
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Choe SK, Ladam F, Sagerstr?m CG. TALE factors poise promoters for activation by Hox proteins. Dev Cell. 2014 Jan 27; 28(2):203-11.
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Adamik J, Wang KZ, Unlu S, Su AJ, Tannahill GM, Galson DL, O'Neill LA, Auron PE. Distinct mechanisms for induction and tolerance regulate the immediate early genes encoding interleukin 1? and tumor necrosis factor a. PLoS One. 2013; 8(8):e70622.
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Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol. 2010 Feb; 17(2):194-201.
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Gomes NP, Bjerke G, Llorente B, Szostek SA, Emerson BM, Espinosa JM. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev. 2006 Mar 01; 20(5):601-12.
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Br?s V, Gomes N, Pickle L, Jones KA. A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. Genes Dev. 2005 May 15; 19(10):1211-26.
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Gomes N, Garber ME, Jones KA. Techniques to analyze the HIV-1 Tat and TAR RNA-dependent recruitment and activation of the cyclin T1: CDK9 (P-TEFb) transcription elongation factor. Methods Enzymol. 2003; 371:324-36.
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