 Transforming Growth Factor beta
"Transforming Growth Factor beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
| Descriptor ID |
D016212
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| MeSH Number(s) |
D12.644.276.374.687 D12.644.276.954.775 D12.776.467.374.687 D12.776.467.942.775 D23.529.374.687 D23.529.942.775
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| Concept/Terms |
Transforming Growth Factor beta- Transforming Growth Factor beta
- Milk Growth Factor
- Factor, Milk Growth
- Growth Factor, Milk
- TGF-beta
- TGFbeta
- Platelet Transforming Growth Factor
- Bone-Derived Transforming Growth Factor
- Bone Derived Transforming Growth Factor
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Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta".
Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta".
This graph shows the total number of publications written about "Transforming Growth Factor beta" by people in this website by year, and whether "Transforming Growth Factor beta" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1991 | 5 | 3 | 8 | | 1992 | 5 | 0 | 5 | | 1993 | 1 | 3 | 4 | | 1994 | 3 | 1 | 4 | | 1995 | 1 | 2 | 3 | | 1996 | 2 | 0 | 2 | | 1997 | 6 | 2 | 8 | | 1998 | 1 | 3 | 4 | | 1999 | 4 | 1 | 5 | | 2000 | 5 | 1 | 6 | | 2001 | 1 | 0 | 1 | | 2002 | 9 | 8 | 17 | | 2003 | 9 | 8 | 17 | | 2004 | 16 | 11 | 27 | | 2005 | 13 | 8 | 21 | | 2006 | 8 | 7 | 15 | | 2007 | 11 | 11 | 22 | | 2008 | 8 | 10 | 18 | | 2009 | 11 | 7 | 18 | | 2010 | 5 | 5 | 10 | | 2011 | 1 | 12 | 13 | | 2012 | 10 | 6 | 16 | | 2013 | 7 | 4 | 11 | | 2014 | 5 | 5 | 10 | | 2015 | 2 | 8 | 10 | | 2016 | 6 | 6 | 12 | | 2017 | 5 | 8 | 13 | | 2018 | 1 | 5 | 6 | | 2019 | 5 | 5 | 10 | | 2020 | 2 | 3 | 5 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transforming Growth Factor beta" by people in Profiles.
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Humbert M, McLaughlin V, Gibbs JSR, Gomberg-Maitland M, Hoeper MM, Preston IR, Souza R, Waxman A, Escribano Subias P, Feldman J, Meyer G, Montani D, Olsson KM, Manimaran S, Barnes J, Linde PG, de Oliveira Pena J, Badesch DB. Sotatercept for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2021 04 01; 384(13):1204-1215.
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Takamiya M, Stegmaier J, Kobitski AY, Schott B, Weger BD, Margariti D, Cereceda Delgado AR, Gourain V, Scherr T, Yang L, Sorge S, Otte JC, Hartmann V, van Wezel J, Stotzka R, Reinhard T, Schlunck G, Dickmeis T, Rastegar S, Mikut R, Nienhaus GU, Strähle U. Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves. PLoS Genet. 2020 06; 16(6):e1008774.
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Aschner Y, Nelson M, Brenner M, Roybal H, Beke K, Meador C, Foster D, Correll KA, Reynolds PR, Anderson K, Redente EF, Matsuda J, Riches DWH, Groshong SD, Pozzi A, Sap J, Wang Q, Rajshankar D, McCulloch CAG, Zemans RL, Downey GP. Protein tyrosine phosphatase-a amplifies transforming growth factor-ß-dependent profibrotic signaling in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2020 08 01; 319(2):L294-L311.
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Takahashi S, Luo Y, Ranjit S, Xie C, Libby AE, Orlicky DJ, Dvornikov A, Wang XX, Myakala K, Jones BA, Bhasin K, Wang D, McManaman JL, Krausz KW, Gratton E, Ir D, Robertson CE, Frank DN, Gonzalez FJ, Levi M. Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice. J Biol Chem. 2020 04 03; 295(14):4733-4747.
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Bhagwani AR, Farkas D, Harmon B, Authelet KJ, Cool CD, Kolb M, Goncharova E, Yoder MC, Clauss M, Freishtat R, Farkas L. Clonally selected primitive endothelial cells promote occlusive pulmonary arteriopathy and severe pulmonary hypertension in rats exposed to chronic hypoxia. Sci Rep. 2020 01 24; 10(1):1136.
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Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB. Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment. Sci Rep. 2020 01 15; 10(1):413.
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Aisenbrey EA, Bilousova G, Payne K, Bryant SJ. Dynamic mechanical loading and growth factors influence chondrogenesis of induced pluripotent mesenchymal progenitor cells in a cartilage-mimetic hydrogel. Biomater Sci. 2019 Nov 19; 7(12):5388-5403.
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Welk V, Meul T, Lukas C, Kammerl IE, Mulay SR, Schamberger AC, Semren N, Fernandez IE, Anders HJ, Günther A, Behr J, Eickelberg O, Korfei M, Meiners S. Proteasome activator PA200 regulates myofibroblast differentiation. Sci Rep. 2019 10 23; 9(1):15224.
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Joetham A, Schedel M, Ning F, Wang M, Takeda K, Gelfand EW. Dichotomous role of TGF-ß controls inducible regulatory T-cell fate in allergic airway disease through Smad3 and TGF-ß-activated kinase 1. J Allergy Clin Immunol. 2020 03; 145(3):933-946.e4.
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Kim SK, Henen MA, Hinck AP. Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family. Exp Biol Med (Maywood). 2019 12; 244(17):1547-1558.
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