 Transforming Growth Factor beta
"Transforming Growth Factor beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
| Descriptor ID |
D016212
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| MeSH Number(s) |
D12.644.276.374.687 D12.644.276.954.775 D12.776.467.374.687 D12.776.467.942.775 D23.529.374.687 D23.529.942.775
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| Concept/Terms |
Transforming Growth Factor beta- Transforming Growth Factor beta
- Milk Growth Factor
- Factor, Milk Growth
- Growth Factor, Milk
- TGF-beta
- TGFbeta
- Platelet Transforming Growth Factor
- Bone-Derived Transforming Growth Factor
- Bone Derived Transforming Growth Factor
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Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta".
Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta".
This graph shows the total number of publications written about "Transforming Growth Factor beta" by people in this website by year, and whether "Transforming Growth Factor beta" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 2 | 2 | 4 | | 1996 | 3 | 0 | 3 | | 1997 | 7 | 2 | 9 | | 1998 | 2 | 2 | 4 | | 1999 | 3 | 2 | 5 | | 2000 | 5 | 2 | 7 | | 2001 | 2 | 1 | 3 | | 2002 | 9 | 6 | 15 | | 2003 | 7 | 8 | 15 | | 2004 | 14 | 9 | 23 | | 2005 | 11 | 7 | 18 | | 2006 | 7 | 6 | 13 | | 2007 | 10 | 8 | 18 | | 2008 | 6 | 6 | 12 | | 2009 | 11 | 7 | 18 | | 2010 | 5 | 5 | 10 | | 2011 | 2 | 9 | 11 | | 2012 | 11 | 7 | 18 | | 2013 | 5 | 6 | 11 | | 2014 | 4 | 7 | 11 | | 2015 | 2 | 7 | 9 | | 2016 | 4 | 2 | 6 | | 2017 | 4 | 7 | 11 | | 2018 | 3 | 3 | 6 | | 2019 | 6 | 4 | 10 | | 2020 | 4 | 4 | 8 | | 2021 | 2 | 5 | 7 | | 2022 | 0 | 7 | 7 | | 2023 | 0 | 5 | 5 | | 2024 | 1 | 3 | 4 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transforming Growth Factor beta" by people in Profiles.
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Wilson TM, Bolt M, Stahly A, Lee JS, Bang TJ, Sachs PB, Deane KD, Humphries SM, Solomon JJ, Demoruelle MK. Transforming growth factor-beta is increased in sputum from individuals with rheumatoid arthritis-associated pulmonary fibrosis. Rheumatology (Oxford). 2025 Jun 01; 64(6):3989-3995.
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Nguyen KN, Graner AN, Fringuello AR, Zizzo Z, Valenzuela L, Anyanwu K, Lillehei KO, Youssef AS, Guzman S, Coughlan C, Graner MW. Extracellular Vesicles from a Novel Chordoma Cell Line, ARF-8, Promote Tumorigenic Microenvironmental Changes When Incubated with the Parental Cells and with Human Osteoblasts. Int J Mol Sci. 2024 Nov 27; 25(23).
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Lind HT, Hall SC, Strait AA, Goon JB, Aleman JD, Chen SMY, Karam SD, Young CD, Wang JH, Wang XJ. MHC class I upregulation contributes to the therapeutic response to radiotherapy in combination with anti-PD-L1/anti-TGF-? in squamous cell carcinomas with enhanced CD8 T cell memory-driven response. Cancer Lett. 2025 Jan 01; 608:217347.
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Santos ARMP, Kirkpatrick BE, Kim M, Anseth KS, Park Y. 2D co-culture model reveals a biophysical interplay between activated fibroblasts and cancer cells. Acta Biomater. 2024 Dec; 190:264-272.
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K?nzel SH, Pohlmann D, Bonsen LZ, Krappitz M, Zeitz O, Joussen AM, Dubrac A, K?nzel SE. Transcriptome Analysis of Choroidal Endothelium Links Androgen Receptor Role to Central Serous Chorioretinopathy. Eur J Ophthalmol. 2024 Sep; 34(5):1532-1540.
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Li X, Ke Y, Hernandez AL, Yu J, Bian L, Hall SC, Nolan K, Wang JH, Young CD, Wang XJ. Inducible nitric oxide synthase (iNOS)-activated Cxcr2 signaling in myeloid cells promotes TGF?-dependent squamous cell carcinoma lung metastasis. Cancer Lett. 2023 08 28; 570:216330.
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Plecit?-Hlavat? L, Br?zdov? A, Krivonoskov? M, Hu CJ, Phang T, Tauber J, Li M, Zhang H, Hoetzenecker K, Crnkovic S, Kwapiszewska G, Stenmark KR. Microenvironmental regulation of T-cells in pulmonary hypertension. Front Immunol. 2023; 14:1223122.
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Cheng HS, P?rez-Cremades D, Zhuang R, Jamaiyar A, Wu W, Chen J, Tzani A, Stone L, Plutzky J, Ryan TE, Goodney PP, Creager MA, Sabatine MS, Bonaca MP, Feinberg MW. Impaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b/INHBA signaling axis. JCI Insight. 2023 05 22; 8(10).
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Kim Y, Mastali M, Van Eyk JE, Orav EJ, Vissing CR, Day SM, Axelsson Raja A, Russell MW, Zahka K, Lever HM, Pereira AC, Murphy AM, Canter C, Bach RG, Wheeler MT, Rossano JW, Owens AT, Bundgaard H, Benson L, Mestroni L, Taylor MRG, Patel AR, Wilmot I, Thrush P, Soslow JH, Becker JR, Seidman CE, Ho CY. Transforming Growth Factor-? Analysis of the VANISH Trial Cohort. Circ Heart Fail. 2023 04; 16(4):e010314.
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Fandl HK, Garcia VP, Treuth JW, Brewster LM, Greiner JJ, Davy KP, Stauffer BL, Desouza CA. Endothelial-derived extracellular vesicles from obese/hypertensive adults increase factors associated with hypertrophy and fibrosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2023 05 01; 324(5):H675-H685.
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