 Topoisomerase Inhibitors
"Topoisomerase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds that inhibit the activity of DNA TOPOISOMERASES.
| Descriptor ID |
D059003
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| MeSH Number(s) |
D27.505.519.389.892 D27.505.954.248.794
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| Concept/Terms |
Topoisomerase Inhibitors- Topoisomerase Inhibitors
- Inhibitors, Topoisomerase
- DNA Topoisomerase Inhibitors
- Inhibitors, DNA Topoisomerase
- Topoisomerase Inhibitors, DNA
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Below are MeSH descriptors whose meaning is more general than "Topoisomerase Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Topoisomerase Inhibitors".
This graph shows the total number of publications written about "Topoisomerase Inhibitors" by people in this website by year, and whether "Topoisomerase Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Topoisomerase Inhibitors" by people in Profiles.
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Bax BD, Murshudov G, Maxwell A, Germe T. DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion. J Mol Biol. 2019 08 23; 431(18):3427-3449.
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Jeannot F, Taillier T, Despeyroux P, Renard S, Rey A, Mourez M, Poeverlein C, Khichane I, Perrin MA, Versluys S, Stavenger RA, Huang J, Germe T, Maxwell A, Cao S, Huseby DL, Hughes D, Bacqu? E. Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones. J Med Chem. 2018 04 26; 61(8):3565-3581.
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Haeger SM, Thompson JJ, Kalra S, Cleaver TG, Merrick D, Wang XJ, Malkoski SP. Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors. Oncogene. 2016 Feb 04; 35(5):577-586.
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Fasulo B, Koyama C, Yu KR, Homola EM, Hsieh TS, Campbell SD, Sullivan W. Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry. Mol Biol Cell. 2012 Mar; 23(6):1047-57.
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Shewach DS, Kuchta RD. Introduction to cancer chemotherapeutics. Chem Rev. 2009 Jul; 109(7):2859-61.
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