Catechol O-Methyltransferase Inhibitors
"Catechol O-Methyltransferase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE.
| Descriptor ID |
D065098
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| MeSH Number(s) |
D27.505.519.389.237 D27.505.954.427.090.050.500
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Catechol O-Methyltransferase Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Catechol O-Methyltransferase Inhibitors".
This graph shows the total number of publications written about "Catechol O-Methyltransferase Inhibitors" by people in this website by year, and whether "Catechol O-Methyltransferase Inhibitors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Catechol O-Methyltransferase Inhibitors" by people in Profiles.
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Schacht JP, Hoffman M, Voronin KE, Book SW, Anton RF. Effects of pharmacological and genetic regulation of COMT activity in alcohol use disorder: a randomized, placebo-controlled trial of tolcapone. Neuropsychopharmacology. 2022 10; 47(11):1953-1960.
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Schacht JP. COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review. Pharmacogenomics J. 2016 10; 16(5):430-8.
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Gottwald MD, Bainbridge JL, Dowling GA, Aminoff MJ, Alldredge BK. New pharmacotherapy for Parkinson's disease. Ann Pharmacother. 1997 Oct; 31(10):1205-17.
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Altiere RJ, Douglas JS, Gillis CN. Pharmacological analysis of norepinephrine responses in rabbit pulmonary blood vessels. J Pharmacol Exp Ther. 1983 Mar; 224(3):579-89.