 DNA-Directed DNA Polymerase
"DNA-Directed DNA Polymerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
| Descriptor ID |
D004259
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| MeSH Number(s) |
D08.811.913.696.445.308.300
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| Concept/Terms |
DNA-Directed DNA Polymerase- DNA-Directed DNA Polymerase
- DNA Directed DNA Polymerase
- DNA Polymerase, DNA-Directed
- Polymerase, DNA-Directed DNA
- DNA-Dependent DNA Polymerases
- DNA Dependent DNA Polymerases
- DNA Polymerases, DNA-Dependent
- Polymerases, DNA-Dependent DNA
- DNA Polymerases
- Polymerases, DNA
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Below are MeSH descriptors whose meaning is more general than "DNA-Directed DNA Polymerase".
Below are MeSH descriptors whose meaning is more specific than "DNA-Directed DNA Polymerase".
This graph shows the total number of publications written about "DNA-Directed DNA Polymerase" by people in this website by year, and whether "DNA-Directed DNA Polymerase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1998 | 1 | 1 | 2 | | 1999 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 1 | 2 | | 2005 | 2 | 0 | 2 | | 2006 | 3 | 0 | 3 | | 2007 | 2 | 0 | 2 | | 2008 | 2 | 0 | 2 | | 2009 | 2 | 0 | 2 | | 2010 | 1 | 1 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 2 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 2 | 0 | 2 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA-Directed DNA Polymerase" by people in Profiles.
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Zatopek KM, Alpaslan E, Evans TC, Sauguet L, Gardner AF. Novel ribonucleotide discrimination in the RNA polymerase-like two-barrel catalytic core of Family D DNA polymerases. Nucleic Acids Res. 2020 12 02; 48(21):12204-12218.
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Shukla S, Jeong HC, Sturgeon CM, Parker R, Batista LFZ. Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita. Blood Adv. 2020 06 23; 4(12):2717-2722.
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P?rez Di Giorgio JA, Lepage ?, Tremblay-Belzile S, Truche S, Loubert-Hudon A, Brisson N. Transcription is a major driving force for plastid genome instability in Arabidopsis. PLoS One. 2019; 14(4):e0214552.
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Dickerson SM, Kuchta RD. Protein Displacement by Herpes Helicase-Primase and the Key Role of UL42 during Helicase-Coupled DNA Synthesis by the Herpes Polymerase. Biochemistry. 2017 05 30; 56(21):2651-2662.
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Alhadid Y, Chung S, Lerner E, Taatjes DJ, Borukhov S, Weiss S. Studying transcription initiation by RNA polymerase with diffusion-based single-molecule fluorescence. Protein Sci. 2017 Jul; 26(7):1278-1290.
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Vashishtha AK, Kuchta RD. Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA. Biochemistry. 2016 Feb 23; 55(7):1168-77.
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Dohrmann PR, Correa R, Frisch RL, Rosenberg SM, McHenry CS. The DNA polymerase III holoenzyme contains ? and is not a trimeric polymerase. Nucleic Acids Res. 2016 Feb 18; 44(3):1285-97.
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Lee ZB, Firnhaber C, Clarke J, DeDecker BS. Gene and library synthesis without amplification: polymerase step reaction (PSR). Biotechniques. 2015 Sep; 59(3):163-6.
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Vashishtha AK, Kuchta RD. Polymerase and exonuclease activities in herpes simplex virus type 1 DNA polymerase are not highly coordinated. Biochemistry. 2015 Jan 20; 54(2):240-9.
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Brand?o LN, Ferguson R, Santoro I, Jinks-Robertson S, Sclafani RA. The role of Dbf4-dependent protein kinase in DNA polymerase ?-dependent mutagenesis in Saccharomyces cerevisiae. Genetics. 2014 Aug; 197(4):1111-22.
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