 DNA Polymerase I
"DNA Polymerase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.
| Descriptor ID |
D004256
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| MeSH Number(s) |
D08.811.913.696.445.308.300.225
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| Concept/Terms |
DNA Polymerase I- DNA Polymerase I
- Polymerase I, DNA
- Klenow Fragment
- DNA-Dependent DNA Polymerase I
- DNA Dependent DNA Polymerase I
- DNA Pol I
- DNA Polymerase alpha
- Polymerase alpha, DNA
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Below are MeSH descriptors whose meaning is more general than "DNA Polymerase I".
Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase I".
This graph shows the total number of publications written about "DNA Polymerase I" by people in this website by year, and whether "DNA Polymerase I" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 1 | 1 | 2 | | 2002 | 0 | 1 | 1 | | 2003 | 2 | 0 | 2 | | 2004 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 4 | 0 | 4 | | 2011 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Polymerase I" by people in Profiles.
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Zaug AJ, Lim CJ, Olson CL, Carilli MT, Goodrich KJ, Wuttke DS, Cech TR. CST does not evict elongating telomerase but prevents initiation by ssDNA binding. Nucleic Acids Res. 2021 11 18; 49(20):11653-11665.
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Lund TJ, Cavanaugh NA, Joubert N, Urban M, Patro JN, Hocek M, Kuchta RD. B family DNA polymerases asymmetrically recognize pyrimidines and purines. Biochemistry. 2011 Aug 23; 50(33):7243-50.
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Parent JS, Lepage E, Brisson N. Divergent roles for the two PolI-like organelle DNA polymerases of Arabidopsis. Plant Physiol. 2011 May; 156(1):254-62.
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Patro JN, Urban M, Kuchta RD. Interaction of human DNA polymerase alpha and DNA polymerase I from Bacillus stearothermophilus with hypoxanthine and 8-oxoguanine nucleotides. Biochemistry. 2009 Sep 01; 48(34):8271-8.
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Stengel G, Purse BW, Wilhelmsson LM, Urban M, Kuchta RD. Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase alpha and Klenow fragment. Biochemistry. 2009 Aug 11; 48(31):7547-55.
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Trostler M, Delier A, Beckman J, Urban M, Patro JN, Spratt TE, Beese LS, Kuchta RD. Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus. Biochemistry. 2009 Jun 02; 48(21):4633-41.
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Patro JN, Urban M, Kuchta RD. Role of the 2-amino group of purines during dNTP polymerization by human DNA polymerase alpha. Biochemistry. 2009 Jan 13; 48(1):180-9.
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Cavanaugh NA, Kuchta RD. Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha. J Biol Chem. 2009 Jan 16; 284(3):1523-32.
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Beckman J, Kincaid K, Hocek M, Spratt T, Engels J, Cosstick R, Kuchta RD. Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity. Biochemistry. 2007 Jan 16; 46(2):448-60.
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Kincaid K, Beckman J, Zivkovic A, Halcomb RL, Engels JW, Kuchta RD. Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha. Nucleic Acids Res. 2005; 33(8):2620-8.
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