Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Marilyn Manco-Johnson

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-0365

    Collapse Research 
    Collapse research activities and funding
    U34HL114988     (MANCO-JOHNSON, MARILYN J)Aug 15, 2012 - Jan 31, 2015
    NIH
    Clinical Trial Planning Grant in Catheter-Directed Thrombolysis of Occlusive DVT
    Role: Principal Investigator
    U01DD000757     (MANCO-JOHNSON, MARILYN J)Sep 30, 2011 - Sep 29, 2014
    NIH
    Patient-Level Meta-analysis: Effect of age of initiation, intensity and duration
    Role: Principal Investigator
    U01DD000198     (MANCO-JOHNSON, MARILYN J)Sep 30, 2006 - Sep 29, 2011
    NIH
    Prevention of Complications in Hemophilia Through HTCs
    Role: Principal Investigator
    U01DD000016     (MANCO-JOHNSON, MARILYN J)Jul 1, 2004 - May 31, 2012
    NIH
    Models of Care and Research in Thrombosis and Thrombophilia
    Role: Principal Investigator
    U18DD000016     (MANCO-JOHNSON, MARILYN J)Jul 1, 2004 - Jun 30, 2007
    NIH
    Integrating Prevention Services for Bleeding &Clottiing
    Role: Principal Investigator
    R01HL044586     (MANCO-JOHNSON, MARILYN J)Aug 1, 1990 - Jan 30, 1994
    NIH
    ONTOGENY OF THE PROTEIN C SYSTEM
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wischmeyer JT, Baird CH, Grandvallet Contreras J, Tran A, Phang T, Liu T, Manco-Johnson MJ. A Naturally Occurring Gain-of-Function Mutation in Factor VIII. N Engl J Med. 2025 Aug 14; 393(7):722-724. PMID: 40802951.
      View in: PubMed
    2. Manco-Johnson M, Brons P, Knoebl P, Wang M, Siffel C, Turecek PL, Gazda HT. Real-world use of protein C concentrate for the treatment of patients with protein C deficiency: an international registry. J Thromb Haemost. 2025 Nov; 23(11):3569-3577. PMID: 40706962.
      View in: PubMed
    3. Rojas-Sanchez G, Calzada-Martinez J, McMahon B, Petrey AC, Dveksler G, Espino-Solis GP, Esparza O, Hernandez G, Le D, Wartchow EP, Jones K, Ting LH, Jankowski C, Kelher MR, Manco-Johnson M, Feser ML, Deane KD, Nemkov T, D'Alessandro A, Thorburn A, Maycotte P, López JA, Davizon-Castillo P. TNF-a impairs platelet function by inhibiting autophagy and disrupting metabolism via syntaxin 17 downregulation. J Clin Invest. 2025 Aug 01; 135(15). PMID: 40493419.
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    4. Fan MN, Shen T, Konkle BA, Cai X, Chao TY, Manco-Johnson M, Faino AV, Zhang J, Bao S, Xiao W, Li L, Miao CH. Exploration of biomarkers for inhibitor development in persons with hemophilia A. Res Pract Thromb Haemost. 2025 May; 9(4):102877. PMID: 40502463.
      View in: PubMed
    5. Manco-Johnson MJ, Le B, Acharya S, Ahuja S, Chitlur M, Citla-Sridhar D, Fedewa SA, Isaac D, Kulkarni R, Schieve LA, Sharathkumar A, Soucie JM. Risk factors for joint bleeding in severe hemophilia A and B: analysis of the Community Counts longitudinal surveillance cohort. Blood Vessel Thromb Hemost. 2025 Aug; 2(3):100047. PMID: 40823317.
      View in: PubMed
    6. Goldenberg NA, Schulman S, Kittelson JM, Abshire TC, Casella JF, Dale R, Halperin JL, Hanson J, Kessler CM, Manco-Johnson MJ, McDevitt L, Sidonio RF, Spyropoulos AC, Steg PG, Bonaca MP. Duration of anticoagulation for venous thromboembolism in pediatric patients: Evaluation of the Duration of Therapy for Thrombosis in Children (Kids-DOTT) trial outcomes at 2 years. J Thromb Haemost. 2025 Feb; 23(2):651-656. PMID: 39461724.
      View in: PubMed
    7. Mah J, Robertson C, Mah N, Roybal J, Thornhill D, Funk S, Manco-Johnson MJ, Carollo J, Gaffney BMM, Warren BB. Joint reaction and simulated muscle forces during squatting and walking in persons with hemophilia. Clin Biomech (Bristol). 2024 Dec; 120:106361. PMID: 39461281.
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    8. Manco-Johnson MJ, Annam A, Schardt T. Anticoagulation in Pediatric Patients. Tech Vasc Interv Radiol. 2024 Jun; 27(2):100958. PMID: 39168548.
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    9. Herzog E, Zavaletta V, Katz D, Lindquist J, Manco-Johnson M, Schardt T, Annam A. Interventional Treatment of Pediatric Venous Thromboembolic Disease. Tech Vasc Interv Radiol. 2024 Jun; 27(2):100957. PMID: 39168544.
      View in: PubMed
    10. Han JH, Dupervil B, Mahajerin A, Kulkarni R, Manco-Johnson M, Thornburg C. Clinical and treatment characteristics of infants and toddlers less than 2 years of age with hemophilia. Blood Adv. 2024 06 11; 8(11):2707-2717. PMID: 38547443.
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    11. Moreira DC, Garrido C, Rosado R, Gir?n V, Letona T, Morales G, Valverde P, Vel?squez T, Alfaro J, Orellana E, Ortega MA, Salguero P, Fox Irwin L, Andujar A, de Alarc?n PA, Luna-Fineman S, Manco-Johnson M, Conter V, Verna M, Canesi M, Massimino M, Spreafico F, Ferrari A, Gassant PY, V?squez R, Friedrich P, Mack R, Ribeiro R, Metzger ML, Rodriguez-Galindo C, Antill?n-Klussmann F. Impact of a Regional Pediatric Hematology/Oncology Fellowship Program in Guatemala. JCO Glob Oncol. 2024 Jun; 10:e2300474. PMID: 38870436.
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    12. Manco-Johnson MJ. Life after pediatric pulmonary embolism. Blood. 2024 02 15; 143(7):569-570. PMID: 38358847.
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    13. Casini A, Abdul Kadir R, Abdelwahab M, Manco-Johnson MJ, Raut S, Ross C, de Moerloose P, Santoro C, Acharya S. Management of pregnancy and delivery in congenital fibrinogen disorders: communication from the ISTH SSC Subcommittee on Factor XIII and Fibrinogen. J Thromb Haemost. 2024 May; 22(5):1516-1521. PMID: 38266678.
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    14. Warren BB, Moyer GC, Manco-Johnson MJ. Hemostasis in the Pregnant Woman, the Placenta, the Fetus, and the Newborn Infant. Semin Thromb Hemost. 2023 Jun; 49(4):319-329. PMID: 36750218.
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    15. Manco-Johnson MJ, Warren BB. Long-term prophylaxis: what are our options and how to define success? Hematology Am Soc Hematol Educ Program. 2022 12 09; 2022(1):579-585. PMID: 36485126.
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    16. Curtis R, Manco-Johnson M, Konkle BA, Kulkarni R, Wu J, Baker JR, Ullman M, Tran DQ, Nichol MB. Comorbidities, Health-Related Quality of Life, Health-care Utilization in Older Persons with Hemophilia-Hematology Utilization Group Study Part VII (HUGS VII). J Blood Med. 2022; 13:229-241. PMID: 35585877.
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    17. Galanakis DK, Protopopova A, Li K, Yu Y, Ahmed T, Senzel L, Heslin R, Gouda M, Koo J, Weisel J, Manco-Johnson M, Rafailovich M. Correction to: Novel characteristics of soluble fibrin: hypercoagulability and acceleration of blood sedimentation rate mediated by its generation of erythrocyte-linked fibers. Cell Tissue Res. 2022 May; 388(2):487. PMID: 35377052.
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    18. St-Louis J, Abad A, Funk S, Tilak M, Classey S, Zourikian N, McLaughlin P, Lobet S, Hernandez G, Akins S, Wells AJ, Manco-Johnson M, John J, Austin S, Chowdhary P, Hermans C, Nugent D, Bakeer N, Mangles S, Hilliard P, Blanchette VS, Feldman BM. The Hemophilia Joint Health Score version 2.1 Validation in Adult Patients Study: A multicenter international study. Res Pract Thromb Haemost. 2022 Feb; 6(2):e12690. PMID: 35356667.
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    19. Galanakis DK, Protopopova A, Li K, Yu Y, Ahmed T, Senzel L, Heslin R, Gouda M, Koo J, Weisel J, Manco-Johnson M, Rafailovich M. Novel characteristics of soluble fibrin: hypercoagulability and acceleration of blood sedimentation rate mediated by its generation of erythrocyte-linked fibers. Cell Tissue Res. 2022 Mar; 387(3):479-491. PMID: 35275281.
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    20. Goldenberg NA, Kittelson JM, Abshire TC, Bonaca M, Casella JF, Dale RA, Halperin JL, Hamblin F, Kessler CM, Manco-Johnson MJ, Sidonio RF, Spyropoulos AC, Steg PG, Turpie AGG, Schulman S. Effect of Anticoagulant Therapy for 6 Weeks vs 3 Months on Recurrence and Bleeding Events in Patients Younger Than 21 Years of Age With Provoked Venous Thromboembolism: The Kids-DOTT Randomized Clinical Trial. JAMA. 2022 01 11; 327(2):129-137. PMID: 35015038.
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    21. Warren BB, Chan A, Manco-Johnson M, Branchford BR, Buckner TW, Moyer G, Gibson E, Thornhill D, Wang M, Ng CJ. Emicizumab initiation and bleeding outcomes in people with hemophilia A with and without inhibitors: A single-center report. Res Pract Thromb Haemost. 2021 Jul; 5(5):e12571. PMID: 34377887.
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    22. Bakeer N, Dover S, Babyn P, Feldman BM, von Drygalski A, Doria AS, Ignas DM, Abad A, Bailey C, Beggs I, Chang EY, Dunn A, Funk S, Gibikote S, Goddard N, Hilliard P, Keshava SN, Kruse-Jarres R, Li Y, Lobet S, Manco-Johnson M, Martinoli C, O'Donnell JS, Papakonstantinou O, Pergantou H, Poonnoose P, Querol F, Srivastava A, Steiner B, Strike K, Timmer M, Tyrrell PN, Vidarsson L, Blanchette VS. Musculoskeletal ultrasound in hemophilia: Results and recommendations from a global survey and consensus meeting. Res Pract Thromb Haemost. 2021 Jul; 5(5):e12531. PMID: 34268464.
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    23. Ng CJ, Spomer N, Shearer R, LeBlanc A, Funk S, Manco-Johnson M, Branchford B, Warren B, Buckner TW, Cowell A, Moyer G, Wang M, Gibson E, Mashburn C. Improvements in Communication and Coordination of Care in a Hemophilia Treatment Center. Acta Haematol. 2021; 144(6):672-677. PMID: 33915533.
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    24. Smith J, Thornhill D, Goldenberg NA, Brand?o L, Knapp-Clevenger R, Warren BB, Sung L, Kahn SR, Manco-Johnson M. Validation of Outcome Instruments for Pediatric Postthrombotic Syndrome: Introducing the Peds-VEINES-QOL, a New Health-Related Quality of Life Instrument. Thromb Haemost. 2021 Oct; 121(10):1367-1375. PMID: 33706398.
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    25. Smith N, Warren BB, Smith J, Jacobson L, Armstrong J, Kim J, Di Paola J, Manco-Johnson M. Antithrombin deficiency: A pediatric disorder. Thromb Res. 2021 06; 202:45-51. PMID: 33725558.
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    26. Manco-Johnson MJ, Warren BB, Buckner TW, Funk SM, Wang M. Outcome measures in Haemophilia: Beyond ABR (Annualized Bleeding Rate). Haemophilia. 2021 Feb; 27 Suppl 3:87-95. PMID: 33398908.
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    27. Rajpurkar M, Forsyth A, Manco-Johnson M. Current challenges for men and women with mild-to-moderate haemophilia. Haemophilia. 2021 Jan; 27 Suppl 1:5-7. PMID: 33522655.
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    28. Kuijlaars IAR, van der Net J, Feldman BM, Aspdahl M, Bladen M, de Boer W, Cuesta-Barriuso R, Matlary RED, Funk SM, Hilliard P, John JA, Kempton CL, de Kleijn P, Manco-Johnson M, Petrini P, Poonnoose P, St-Louis J, Thomas S, Timmer MA, Trakymiene SS, van Vlimmeren L, Fischer K. Evaluating international Haemophilia Joint Health Score (HJHS) results combined with expert opinion: Options for a shorter HJHS. Haemophilia. 2020 Nov; 26(6):1072-1080. PMID: 33058441.
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    29. Maher KN, Gibson E, Warren BB, Funk SM, Shearer R, Buckner TW, Wang M, Manco-Johnson MJ, Ng CJ. Prophylaxis for children with moderate hemophilia: Use of a guideline to increase early initiation. Pediatr Blood Cancer. 2021 01; 68(1):e28577. PMID: 32881253.
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    30. Goldscheitter G, Recht M, Sochacki P, Manco-Johnson M, Taylor JA. Biomarkers of bone disease in persons with haemophilia. Haemophilia. 2021 Jan; 27(1):149-155. PMID: 32856388.
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    31. Slatnick LR, Thornhill D, Deakyne Davies SJ, Ford JB, Scott HF, Manco-Johnson MJ, Warren BB. Disseminated Intravascular Coagulation Is an Independent Predictor of Adverse Outcomes in Children in the Emergency Department with Suspected Sepsis. J Pediatr. 2020 10; 225:198-206.e2. PMID: 32553867.
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    32. Warren BB, Thornhill D, Stein J, Fadell M, Ingram JD, Funk S, Norton KL, Lane HD, Bennett CM, Dunn A, Recht M, Shapiro A, Manco-Johnson MJ. Young adult outcomes of childhood prophylaxis for severe hemophilia A: results of the Joint Outcome Continuation Study. Blood Adv. 2020 06 09; 4(11):2451-2459. PMID: 32492157.
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    33. Funk SM, Engelen S, Benjamin K, Moshkovich O, Gentile B, Church N, Hong W, Thornhill D, Manco-Johnson MJ. Validity and reliability of the Colorado Adult Joint Assessment Scale in adults with moderate-severe hemophilia A. J Thromb Haemost. 2020 02; 18(2):285-294. PMID: 31557391.
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    34. Link KG, Stobb MT, Sorrells MG, Bortot M, Ruegg K, Manco-Johnson MJ, Di Paola JA, Sindi SS, Fogelson AL, Leiderman K, Neeves KB. A mathematical model of coagulation under flow identifies factor V as a modifier of thrombin generation in hemophilia A. J Thromb Haemost. 2020 02; 18(2):306-317. PMID: 31562694.
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    35. Warren BB, Jacobson L, Kempton C, Buchanan GR, Recht M, Brown D, Leissinger C, Shapiro AD, Abshire TC, Manco-Johnson MJ. Factor VIII prophylaxis effects outweigh other hemostasis contributors in predicting severe haemophilia A joint outcomes. Haemophilia. 2019 Sep; 25(5):867-875. PMID: 31115111.
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    36. Kim JS, Kaufman J, Patel SS, Manco-Johnson M, Di Paola J, da Cruz EM. Antiplatelet Effect of Ketorolac in Children After Congenital Cardiac Surgery. World J Pediatr Congenit Heart Surg. 2018 11; 9(6):651-658. PMID: 30322371.
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    37. Smith N, Bornikova L, Noetzli L, Guglielmone H, Minoldo S, Backos DS, Jacobson L, Thornburg CD, Escobar M, White-Adams TC, Wolberg AS, Manco-Johnson M, Di Paola J. Identification and characterization of novel mutations implicated in congenital fibrinogen disorders. Res Pract Thromb Haemost. 2018 Oct; 2(4):800-811. PMID: 30349899.
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    38. Sood SL, Cheng D, Ragni M, Kessler CM, Quon D, Shapiro AD, Key NS, Manco-Johnson MJ, Cuker A, Kempton C, Wang TF, Eyster ME, Kuriakose P, von Drygalski A, Gill JC, Wheeler A, Kouides P, Escobar MA, Leissinger C, Galdzicka S, Corson M, Watson C, Konkle BA. A cross-sectional analysis of cardiovascular disease in the hemophilia population. Blood Adv. 2018 06 12; 2(11):1325-1333. PMID: 29895623.
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    39. Manco-Johnson MJ, Byams VR, Recht M, Dudley B, Dupervil B, Aschman DJ, Oakley M, Kapica S, Voutsis M, Humes S, Kulkarni R, Grant AM. Community counts: Evolution of a national surveillance system for bleeding disorders. Am J Hematol. 2018 06; 93(6):E137-E140. PMID: 29473207.
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    40. Ng CJ, McCrae KR, Ashworth K, Sosa LJ, Betapudi V, Manco-Johnson MJ, Liu A, Dong JF, Chung D, White-Adams TC, L?pez JA, Di Paola J. Effects of anti-?2GPI antibodies on VWF release from human umbilical vein endothelial cells and ADAMTS13 activity. Res Pract Thromb Haemost. 2018 Apr; 2(2):380-389. PMID: 30046742.
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    41. Ross C, Rangarajan S, Karimi M, Toogeh G, Apte S, Lissitchkov T, Acharya S, Manco-Johnson MJ, Srivastava A, Brand B, Schwartz BA, Knaub S, Peyvandi F. Pharmacokinetics, clot strength and safety of a new fibrinogen concentrate: randomized comparison with active control in congenital fibrinogen deficiency. J Thromb Haemost. 2018 02; 16(2):253-261. PMID: 29220876.
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    42. Tarango C, Manco-Johnson MJ. Pediatric Thrombolysis: A Practical Approach. Front Pediatr. 2017; 5:260. PMID: 29270396.
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    43. Lehmann M, Ashworth K, Manco-Johnson M, Di Paola J, Neeves KB, Ng CJ. Evaluation of a microfluidic flow assay to screen for von Willebrand disease and low von Willebrand factor levels. J Thromb Haemost. 2018 01; 16(1):104-115. PMID: 29064615.
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    44. Nuytemans K, Ortel TL, Gomez L, Hofmann N, Alves N, Dueker N, Beecham A, Whitehead P, Hahn Estabrooks S, Kitchens CS, Erkan D, Brandão LR, James AH, Kulkarni R, Manco-Johnson MJ, Pericak-Vance MA, Vance JM. Variants in chondroitin sulfate metabolism genes in thrombotic storm. Thromb Res. 2018 01; 161:43-51. PMID: 29178990.
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    45. Manco-Johnson MJ, Lundin B, Funk S, Peterfy C, Raunig D, Werk M, Kempton CL, Reding MT, Goranov S, Gercheva L, Rusen L, Uscatescu V, Pierdominici M, Engelen S, Pocoski J, Walker D, Hong W. Effect of late prophylaxis in hemophilia on joint status: a randomized trial. J Thromb Haemost. 2017 11; 15(11):2115-2124. PMID: 28836341.
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    46. Andersson NG, Auerswald G, Barnes C, Carcao M, Dunn AL, Fijnvandraat K, Hoffmann M, Kavakli K, Kenet G, Kobelt R, Kurnik K, Liesner R, M?kipernaa A, Manco-Johnson MJ, Mancuso ME, Molinari AC, Nolan B, Perez Garrido R, Petrini P, Platokouki HE, Shapiro AD, Wu R, Ljung R. Intracranial haemorrhage in children and adolescents with severe haemophilia A or B - the impact of prophylactic treatment. Br J Haematol. 2017 10; 179(2):298-307. PMID: 28699675.
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    47. Manco-Johnson MJ, Soucie JM, Gill JC. Prophylaxis usage, bleeding rates, and joint outcomes of hemophilia, 1999 to 2010: a surveillance project. Blood. 2017 04 27; 129(17):2368-2374. PMID: 28183693.
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    48. Kulkarni R, Presley RJ, Lusher JM, Shapiro AD, Gill JC, Manco-Johnson M, Koerper MA, Abshire TC, DiMichele D, Hoots WK, Mathew P, Nugent DJ, Geraghty S, Evatt BL, Soucie JM. Complications of haemophilia in babies (first two years of life): a report from the Centers for Disease Control and Prevention Universal Data Collection System. Haemophilia. 2017 Mar; 23(2):207-214. PMID: 27813214.
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    49. Boylan B, Rice AS, Neff AT, Manco-Johnson MJ, Kempton CL, Miller CH. Survey of the anti-factor IX immunoglobulin profiles in patients with hemophilia B using a fluorescence-based immunoassay. J Thromb Haemost. 2016 10; 14(10):1931-1940. PMID: 27501440.
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    50. Fischer K, Poonnoose P, Dunn AL, Babyn P, Manco-Johnson MJ, David JA, van der Net J, Feldman B, Berger K, Carcao M, de Kleijn P, Silva M, Hilliard P, Doria A, Srivastava A, Blanchette V. Choosing outcome assessment tools in haemophilia care and research: a multidisciplinary perspective. Haemophilia. 2017 Jan; 23(1):11-24. PMID: 27633342.
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    51. Bernard TJ, Beslow LA, Manco-Johnson MJ, Armstrong-Wells J, Boada R, Weitzenkamp D, Hollatz A, Poisson S, Amlie-Lefond C, Lo W, deVeber G, Goldenberg NA, Dowling MM, Roach ES, Fullerton HJ, Benseler SM, Jordan LC, Kirton A, Ichord RN. Inter-Rater Reliability of the CASCADE Criteria: Challenges in Classifying Arteriopathies. Stroke. 2016 10; 47(10):2443-9. PMID: 27633024.
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    52. Peyvandi F, Mannucci PM, Garagiola I, El-Beshlawy A, Elalfy M, Ramanan V, Eshghi P, Hanagavadi S, Varadarajan R, Karimi M, Manglani MV, Ross C, Young G, Seth T, Apte S, Nayak DM, Santagostino E, Mancuso ME, Sandoval Gonzalez AC, Mahlangu JN, Bonanad Boix S, Cerqueira M, Ewing NP, Male C, Owaidah T, Soto Arellano V, Kobrinsky NL, Majumdar S, Perez Garrido R, Sachdeva A, Simpson M, Thomas M, Zanon E, Antmen B, Kavakli K, Manco-Johnson MJ, Martinez M, Marzouka E, Mazzucconi MG, Neme D, Palomo Bravo A, Paredes Aguilera R, Prezotti A, Schmitt K, Wicklund BM, Zulfikar B, Rosendaal FR. A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A. N Engl J Med. 2016 May 26; 374(21):2054-64. PMID: 27223147.
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    53. Manco-Johnson MJ, Bomgaars L, Palascak J, Shapiro A, Geil J, Fritsch S, Pavlova BG, Gelmont D. Efficacy and safety of protein C concentrate to treat purpura fulminans and thromboembolic events in severe congenital protein C deficiency. Thromb Haemost. 2016 07 04; 116(1):58-68. PMID: 27052576.
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    54. Flood VH, Christopherson PA, Gill JC, Friedman KD, Haberichter SL, Bellissimo DB, Udani RA, Dasgupta M, Hoffmann RG, Ragni MV, Shapiro AD, Lusher JM, Lentz SR, Abshire TC, Leissinger C, Hoots WK, Manco-Johnson MJ, Gruppo RA, Boggio LN, Montgomery KT, Goodeve AC, James PD, Lillicrap D, Peake IR, Montgomery RR. Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States. Blood. 2016 05 19; 127(20):2481-8. PMID: 26862110.
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    55. Tiede A, Oldenburg J, Lissitchkov T, Knaub S, Bichler J, Manco-Johnson MJ. Prophylaxis vs. on-demand treatment with Nuwiq(?) (Human-cl rhFVIII) in adults with severe haemophilia A. Haemophilia. 2016 May; 22(3):374-80. PMID: 26582282.
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    56. Antun A, Monahan PE, Manco-Johnson MJ, Callaghan MU, Kanin M, Knoll C, Carpenter SL, Davis JA, Guerrera MF, Kruse-Jarres R, Ragni MV, Witmer C, McCracken CE, Kempton CL. Inhibitor recurrence after immune tolerance induction: a multicenter retrospective cohort study. J Thromb Haemost. 2015 Nov; 13(11):1980-8. PMID: 26382916.
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    57. Goldenberg NA, Abshire T, Blatchford PJ, Fenton LZ, Halperin JL, Hiatt WR, Kessler CM, Kittelson JM, Manco-Johnson MJ, Spyropoulos AC, Steg PG, Stence NV, Turpie AG, Schulman S. Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the?Kids-DOTT trial): pilot/feasibility phase findings. J Thromb Haemost. 2015 Sep; 13(9):1597-605. PMID: 26118944.
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    58. Faiz AS, Khan I, Beckman MG, Bockenstedt P, Heit JA, Kulkarni R, Manco-Johnson M, Moll S, Ortel TL, Philipp CS. Characteristics and Risk Factors of Cancer Associated Venous Thromboembolism. Thromb Res. 2015 Sep; 136(3):535-41. PMID: 26168693.
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    59. Lewis DA, Suchindran S, Beckman MG, Hooper WC, Grant AM, Heit JA, Manco-Johnson M, Moll S, Philipp CS, Kenney K, De Staercke C, Pyle ME, Chi JT, Ortel TL. Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism. Thromb Res. 2015 Apr; 135(4):659-65. PMID: 25684211.
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    60. Nakar C, Manco-Johnson MJ, Lail A, Donfield S, Maahs J, Chong Y, Blades T, Shapiro A. Prompt immune tolerance induction at inhibitor diagnosis regardless of titre may increase overall success in haemophilia A complicated by inhibitors: experience of two U.S. centres. Haemophilia. 2015 May; 21(3):365-373. PMID: 25581638.
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    61. McCrindle BW, Li JS, Manlhiot C, Tweddell JS, Giglia TM, Massicotte MP, Monagle P, Krishnamurthy R, Mahaffey KW, Michelson AD, Verdun N, Almond CS, Newburger JW, Brand?o LR, Esmon CT, Manco-Johnson MJ, Ichord R, Ortel TL, Chan AK, Portman R, Rose M, Strony J, Kaltman JR. Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease. Circulation. 2014 Sep 30; 130(14):1192-203. PMID: 25266860.
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    62. Armstrong-Wells J, Donnelly M, Post MD, Manco-Johnson MJ, Winn VD, S?bire G. Inflammatory predictors of neurologic disability after preterm premature rupture of membranes. Am J Obstet Gynecol. 2015 Feb; 212(2):212.e1-9. PMID: 25223243.
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    63. Galanakis DK, Neerman-Arbez M, Brennan S, Rafailovich M, Hyder L, Travlou O, Papadakis E, Manco-Johnson MJ, Henschen A, Scharrer I. Thromboelastographic phenotypes of fibrinogen and its variants: clinical and non-clinical implications. Thromb Res. 2014 Jun; 133(6):1115-23. PMID: 24679643.
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    64. Branchford BR, Ruegg K, Villalobos-Menuey E, Jacobson LJ, Di Paola JA, Manco-Johnson M. FVIII/VWF ratio is not a reliable predictor of VWD in children. Pediatr Blood Cancer. 2014 May; 61(5):936-9. PMID: 24281894.
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    65. Soucie JM, Miller CH, Kelly FM, Payne AB, Creary M, Bockenstedt PL, Kempton CL, Manco-Johnson MJ, Neff AT. A study of prospective surveillance for inhibitors among persons with haemophilia in the United States. Haemophilia. 2014 Mar; 20(2):230-7. PMID: 24261612.
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    66. Onasoga-Jarvis AA, Leiderman K, Fogelson AL, Wang M, Manco-Johnson MJ, Di Paola JA, Neeves KB. The effect of factor VIII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational models. PLoS One. 2013; 8(11):e78732. PMID: 24236042.
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    67. Philipp CS, Faiz AS, Beckman MG, Grant A, Bockenstedt PL, Heit JA, James AH, Kulkarni R, Manco-Johnson MJ, Moll S, Ortel TL. Differences in thrombotic risk factors in black and white women with adverse pregnancy outcome. Thromb Res. 2014 Jan; 133(1):108-11. PMID: 24246297.
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    68. Joachim E, Goldenberg NA, Bernard TJ, Armstrong-Wells J, Stabler S, Manco-Johnson MJ. The methylenetetrahydrofolate reductase polymorphism (MTHFR c.677C>T) and elevated plasma homocysteine levels in a U.S. pediatric population with incident thromboembolism. Thromb Res. 2013 Aug; 132(2):170-4. PMID: 23866722.
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    69. Manco-Johnson MJ, Sanders J, Ewing N, Rodriguez N, Tarantino M, Humphries T. Consequences of switching from prophylactic treatment to on-demand treatment in late teens and early adults with severe haemophilia A: the TEEN/TWEN study. Haemophilia. 2013 Sep; 19(5):727-35. PMID: 23750875.
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    70. Armstrong-Wells J, Post MD, Donnelly M, Manco-Johnson MJ, Fisher BM, Winn VD. Patterns of placental pathology in preterm premature rupture of membranes. J Dev Orig Health Dis. 2013 Jun; 4(3):249-55. PMID: 23828732.
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    71. Manco-Johnson MJ, Kempton CL, Reding MT, Lissitchkov T, Goranov S, Gercheva L, Rusen L, Ghinea M, Uscatescu V, Rescia V, Hong W. Randomized, controlled, parallel-group trial of routine prophylaxis vs. on-demand treatment with sucrose-formulated recombinant factor?VIII in adults with severe hemophilia?A (SPINART). J Thromb Haemost. 2013 Jun; 11(6):1119-27. PMID: 23528101.
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    72. Gupta S, Siddiqi AE, Soucie JM, Manco-Johnson M, Kulkarni R, Lane H, Ingram-Rich R, Gill JC. The effect of secondary prophylaxis versus episodic treatment on the range of motion of target joints in patients with haemophilia. Br J Haematol. 2013 May; 161(3):424-33. PMID: 23432684.
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    73. Landi D, Beckman MG, Shah NR, Bockenstedt P, Grant AM, Heit JA, Key NS, Kulkarni R, Manco-Johnson M, Moll S, Philipp CS, Andersen JC, Ortel TL. Characteristics of abdominal vein thrombosis in children and adults. Thromb Haemost. 2013 Apr; 109(4):625-32. PMID: 23407670.
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    74. Ng C, Silliman CC, Pearl G, Smith W, Manco-Johnson M, Wang M. Treatment of refractory hemorrhage with Factor XIII in a patient with hemophilia A with inhibitor. Pediatr Blood Cancer. 2013 Jul; 60(7):E23-5. PMID: 23382082.
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    75. Goldenberg NA, Bernard TJ, Hillhouse J, Armstrong-Wells J, Galinkin J, Knapp-Clevenger R, Jacobson L, Marcovina SM, Manco-Johnson MJ. Elevated lipoprotein (a), small apolipoprotein (a), and the risk of arterial ischemic stroke in North American children. Haematologica. 2013 May; 98(5):802-7. PMID: 23349301.
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    76. Neeves KB, Onasoga AA, Hansen RR, Lilly JJ, Venckunaite D, Sumner MB, Irish AT, Brodsky G, Manco-Johnson MJ, Di Paola JA. Sources of variability in platelet accumulation on type 1 fibrillar collagen in microfluidic flow assays. PLoS One. 2013; 8(1):e54680. PMID: 23355889.
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    77. Goldenberg NA, Jenkins S, Jack J, Armstrong-Wells J, Fenton LZ, Stence NV, Oleszek J, Boada R, Wilkening GN, Wilkinson C, Soep JB, Miyamoto SD, Bajaj L, Mourani PM, Manco-Johnson MJ, Bernard TJ. Arteriopathy, D-dimer, and risk of poor neurologic outcome in childhood-onset arterial ischemic stroke. J Pediatr. 2013 May; 162(5):1041-6.e1. PMID: 23260102.
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    78. Hancock HS, Wang M, Gist KM, Gibson E, Miyamoto SD, Mourani PM, Manco-Johnson MJ, Goldenberg NA. Cardiac findings and long-term thromboembolic outcomes following pulmonary embolism in children: a combined retrospective-prospective inception cohort study. Cardiol Young. 2013 Jun; 23(3):344-52. PMID: 23088931.
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    79. Moruf A, Spyropoulos AC, Schardt TQ, Gibson E, Manco-Johnson MJ, Wang M, Goldenberg NA. Peri-procedural bridging with low molecular weight heparin in patients receiving warfarin for venous thromboembolism: a pediatric experience. Thromb Res. 2012 Oct; 130(4):612-5. PMID: 22749329.
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    80. Pearson V, Ruzas C, Krebs NF, Goldenberg NA, Manco-Johnson MJ, Bernard TJ. Overweight and obesity are increased in childhood-onset cerebrovascular disease. J Child Neurol. 2013 Apr; 28(4):517-9. PMID: 22647484.
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    81. Manco-Johnson MJ, Wang M, Goldenberg NA, Soep J, Gibson E, Knoll CM, Mourani PM. Treatment, survival, and thromboembolic outcomes of thrombotic storm in children. J Pediatr. 2012 Oct; 161(4):682-8.e1. PMID: 22578585.
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    82. Bombardier C, Villalobos-Menuey E, Ruegg K, Hathaway WE, Manco-Johnson MJ, Goldenberg NA. Monitoring hypercoagulability and hypofibrinolysis following acute venous Thromboembolism in children: application of the CloFAL assay in a prospective inception cohort study. Thromb Res. 2012 Sep; 130(3):343-9. PMID: 22551977.
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    83. Kedia S, Stence N, Manco-Johnson M, Armstrong-Wells J, Bernard TJ. Late cytotoxic edema in 2 children with hemiplegia: hemiplegic migraine or stroke? Headache. 2012 Apr; 52(4):674-8. PMID: 22404149.
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    84. Kenet G, Aronis S, Berkun Y, Bonduel M, Chan A, Goldenberg NA, Holzhauer S, Iorio A, Journeycake J, Junker R, Male C, Manco-Johnson M, Massicotte P, Mesters R, Monagle P, van Ommen H, Rafini L, Simioni P, Young G, Nowak-G?ttl U. Impact of persistent antiphospholipid antibodies on risk of incident symptomatic thromboembolism in children: a systematic review and meta-analysis. Semin Thromb Hemost. 2011 Oct; 37(7):802-9. PMID: 22187403.
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    85. Bernard TJ, Manco-Johnson MJ, Lo W, MacKay MT, Ganesan V, DeVeber G, Goldenberg NA, Armstrong-Wells J, Dowling MM, Roach ES, Tripputi M, Fullerton HJ, Furie KL, Benseler SM, Jordan LC, Kirton A, Ichord R. Towards a consensus-based classification of childhood arterial ischemic stroke. Stroke. 2012 Feb; 43(2):371-7. PMID: 22156694.
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    86. Branchford BR, Mourani P, Bajaj L, Manco-Johnson M, Wang M, Goldenberg NA. Risk factors for in-hospital venous thromboembolism in children: a case-control study employing diagnostic validation. Haematologica. 2012 Apr; 97(4):509-15. PMID: 22133768.
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    87. Branchford BR, Gibson E, Manco-Johnson MJ, Goldenberg NA. Sensitivity of discharge diagnosis ICD-9 codes for pediatric venous thromboembolism is greater than specificity, but still suboptimal for surveillance and clinical research. Thromb Res. 2012 May; 129(5):662-3. PMID: 22104422.
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    88. Bornikova L, Peyvandi F, Allen G, Bernstein J, Manco-Johnson MJ. Fibrinogen replacement therapy for congenital fibrinogen deficiency. J Thromb Haemost. 2011 Sep; 9(9):1687-704. PMID: 21711446.
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    89. Li C, Narkbunnam N, Samulski RJ, Asokan A, Hu G, Jacobson LJ, Manco-Johnson MJ, Monahan PE. Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia. Gene Ther. 2012 Mar; 19(3):288-94. PMID: 21697954.
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    90. Di Paola J, Lethagen S, Gill J, Mannucci P, Manco-Johnson M, Bernstein J, Nichols WL, Bergman GE. Presurgical pharmacokinetic analysis of a von Willebrand factor/factor VIII (VWF/FVIII) concentrate in patients with von Willebrand's disease (VWD) has limited value in dosing for surgery. Haemophilia. 2011 Sep; 17(5):752-8. PMID: 21689209.
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    91. Gill JC, Shapiro A, Valentino LA, Bernstein J, Friedman C, Nichols WL, Manco-Johnson M. von Willebrand factor/factor VIII concentrate (Humate-P) for management of elective surgery in adults and children with von Willebrand disease. Haemophilia. 2011 Nov; 17(6):895-905. PMID: 21535320.
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    92. Simpson ML, Goldenberg NA, Jacobson LJ, Bombardier CG, Hathaway WE, Manco-Johnson MJ. Simultaneous thrombin and plasmin generation capacities in normal and abnormal states of coagulation and fibrinolysis in children and adults. Thromb Res. 2011 Apr; 127(4):317-23. PMID: 21316746.
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    93. Goldenberg NA, Branchford B, Wang M, Ray C, Durham JD, Manco-Johnson MJ. Percutaneous mechanical and pharmacomechanical thrombolysis for occlusive deep vein thrombosis of the proximal limb in adolescent subjects: findings from an institution-based prospective inception cohort study of pediatric venous thromboembolism. J Vasc Interv Radiol. 2011 Feb; 22(2):121-32. PMID: 21216157.
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    94. Bernard TJ, Manco-Johnson MJ, Goldenberg NA. The roles of anatomic factors, thrombophilia, and antithrombotic therapies in childhood-onset arterial ischemic stroke. Thromb Res. 2011 Jan; 127(1):6-12. PMID: 20947137.
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    95. Goldenberg NA, Pounder E, Knapp-Clevenger R, Manco-Johnson MJ. Validation of upper extremity post-thrombotic syndrome outcome measurement in children. J Pediatr. 2010 Nov; 157(5):852-5. PMID: 20797729.
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    96. Goldenberg NA, Donadini MP, Kahn SR, Crowther M, Kenet G, Nowak-G?ttl U, Manco-Johnson MJ. Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors. Haematologica. 2010 Nov; 95(11):1952-9. PMID: 20595095.
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    97. Calhoon MJ, Ross CN, Pounder E, Cassidy D, Manco-Johnson MJ, Goldenberg NA. High prevalence of thrombophilic traits in children with family history of thromboembolism. J Pediatr. 2010 Sep; 157(3):485-9. PMID: 20546786.
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    98. Manco-Johnson MJ. Advances in the care and treatment of children with hemophilia. Adv Pediatr. 2010; 57(1):287-94. PMID: 21056743.
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    99. Armstrong-Wells J, Bernard TJ, Boada R, Manco-Johnson M. Neurocognitive outcomes following neonatal encephalopathy. NeuroRehabilitation. 2010; 26(1):27-33. PMID: 20130353.
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    100. Bernard TJ, Fenton LZ, Apkon SD, Boada R, Wilkening GN, Wilkinson CC, Soep JB, Miyamoto SD, Tripputi M, Armstrong-Wells J, Benke TA, Manco-Johnson MJ, Goldenberg NA. Biomarkers of hypercoagulability and inflammation in childhood-onset arterial ischemic stroke. J Pediatr. 2010 Apr; 156(4):651-6. PMID: 20022340.
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    101. Goldenberg NA, Tripputi M, Crowther M, Abshire TC, DiMichele D, Manco-Johnson MJ, Hiatt WR. The "parallel-cohort RCT": Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolism. Contemp Clin Trials. 2010 Jan; 31(1):131-3. PMID: 19941974.
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    102. Ross C, Goldenberg NA, Hund D, Manco-Johnson MJ. Athletic participation in severe hemophilia: bleeding and joint outcomes in children on prophylaxis. Pediatrics. 2009 Nov; 124(5):1267-72. PMID: 19822585.
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    103. Manco-Johnson MJ, Dimichele D, Castaman G, Fremann S, Knaub S, Kalina U, Peyvandi F, Piseddu G, Mannucci P. Pharmacokinetics and safety of fibrinogen concentrate. J Thromb Haemost. 2009 Dec; 7(12):2064-9. PMID: 19804533.
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    104. Bernard TJ, Goldenberg NA, Tripputi M, Manco-Johnson MJ, Niederstadt T, Nowak-G?ttl U. Anticoagulation in childhood-onset arterial ischemic stroke with non-moyamoya arteriopathy: findings from the Colorado and German (COAG) collaboration. Stroke. 2009 Aug; 40(8):2869-71. PMID: 19478216.
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    105. Manco-Johnson MJ, Hacker MR, Jacobson LJ, Hay WW. Pharmacokinetics of protein C and antithrombin in the fetal lamb: a model to predict human neonatal replacement dosing. Neonatology. 2009; 95(4):279-85. PMID: 19039246.
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    106. Goldenberg NA, Manco-Johnson MJ. Protein C deficiency. Haemophilia. 2008 Nov; 14(6):1214-21. PMID: 19141162.
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    107. Young G, Becker S, D?ring C, Friedrichs F, Goldenberg N, Kenet G, Manco-Johnson M, Scheffold C, Nowak-G?ttl U. Influence of the factor II G20210A variant or the factor V G1691A mutation on symptomatic recurrent venous thromboembolism in children: an international multicenter cohort study. J Thromb Haemost. 2009 Jan; 7(1):72-9. PMID: 18983482.
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    108. Manco-Johnson MJ. When the cause of clotting is not in the blood--it may be the vessel! Pediatr Blood Cancer. 2008 Aug; 51(2):161-2. PMID: 18454463.
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    109. Manco-Johnson MJ. Pediatric thrombophilia and thrombosis: an historical perspective. Hematology Am Soc Hematol Educ Program. 2008; 227. PMID: 19074087.
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    110. Goldenberg NA, Bombardier C, Hathaway WE, McFarland K, Jacobson L, Manco-Johnson MJ. Influence of factor IX on overall plasma coagulability and fibrinolytic potential as measured by global assay: monitoring in haemophilia B. Haemophilia. 2008 Jan; 14(1):68-77. PMID: 18005147.
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    111. Manco-Johnson M. Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practice. Haemophilia. 2007 Sep; 13 Suppl 2:4-9. PMID: 17685917.
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    112. Manco-Johnson MJ, Abshire TC, Shapiro AD, Riske B, Hacker MR, Kilcoyne R, Ingram JD, Manco-Johnson ML, Funk S, Jacobson L, Valentino LA, Hoots WK, Buchanan GR, DiMichele D, Recht M, Brown D, Leissinger C, Bleak S, Cohen A, Mathew P, Matsunaga A, Medeiros D, Nugent D, Thomas GA, Thompson AA, McRedmond K, Soucie JM, Austin H, Evatt BL. Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. N Engl J Med. 2007 Aug 09; 357(6):535-44. PMID: 17687129.
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    113. Hacker MR, Page JH, Shapiro AD, Rich-Edwards JW, Manco-Johnson MJ. Central venous access device infections in children with hemophilia: a comparison of prophylaxis and episodic therapy. J Pediatr Hematol Oncol. 2007 Jul; 29(7):458-64. PMID: 17609623.
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    114. Goldenberg NA, Durham JD, Knapp-Clevenger R, Manco-Johnson MJ. A thrombolytic regimen for high-risk deep venous thrombosis may substantially reduce the risk of postthrombotic syndrome in children. Blood. 2007 Jul 01; 110(1):45-53. PMID: 17360940.
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    115. Hacker MR, Funk SM, Manco-Johnson MJ. The Colorado Haemophilia Paediatric Joint Physical Examination Scale: normal values and interrater reliability. Haemophilia. 2007 Jan; 13(1):71-8. PMID: 17212728.
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    116. Goldenberg NA, Hathaway WE, Jacobson L, McFarland K, Manco-Johnson MJ. Influence of factor VIII on overall coagulability and fibrinolytic potential of haemophilic plasma as measured by global assay: monitoring in haemophilia A. Haemophilia. 2006 Nov; 12(6):605-14. PMID: 17083510.
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    117. Hacker MR, Primeaux J, Manco-Johnson MJ. A patient satisfaction survey for haemophilia treatment centres. Haemophilia. 2006 Mar; 12(2):163-8. PMID: 16476091.
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    118. Goldenberg NA, Manco-Johnson MJ. Pediatric hemostasis and use of plasma components. Best Pract Res Clin Haematol. 2006; 19(1):143-55. PMID: 16377547.
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    119. Manco-Johnson MJ. Postthrombotic syndrome in children. Acta Haematol. 2006; 115(3-4):207-13. PMID: 16549898.
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    120. Goldenberg NA, Knapp-Clevenger R, Hays T, Manco-Johnson MJ. Lemierre's and Lemierre's-like syndromes in children: survival and thromboembolic outcomes. Pediatrics. 2005 Oct; 116(4):e543-8. PMID: 16147971.
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    121. Manco-Johnson MJ. How I treat venous thrombosis in children. Blood. 2006 Jan 01; 107(1):21-9. PMID: 16099882.
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    122. Goldenberg NA, Jacobson L, Manco-Johnson MJ. Brief communication: duration of platelet dysfunction after a 7-day course of Ibuprofen. Ann Intern Med. 2005 Apr 05; 142(7):506-9. PMID: 15809462.
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    123. Kreuz W, Gill JC, Rothschild C, Manco-Johnson MJ, Lusher JM, Kellermann E, Gorina E, Larson PJ. Full-length sucrose-formulated recombinant factor VIII for treatment of previously untreated or minimally treated young children with severe haemophilia A: results of an international clinical investigation. Thromb Haemost. 2005 Mar; 93(3):457-67. PMID: 15735795.
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    124. Manco-Johnson M. Hemophilia management: optimizing treatment based on patient needs. Curr Opin Pediatr. 2005 Feb; 17(1):3-6. PMID: 15659955.
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    125. Manco-Johnson MJ. Risk of stratified therapies for antiphospholipid antibody syndrome (APS) in pregnancy: is tailored treatment ready for prime time? J Thromb Haemost. 2005 Feb; 3(2):240-2. PMID: 15670027.
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    126. Manco-Johnson MJ. Development of hemostasis in the fetus. Thromb Res. 2005 Feb; 115 Suppl 1:55-63. PMID: 15790157.
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    127. Goldenberg NA, Hathaway WE, Jacobson L, Manco-Johnson MJ. A new global assay of coagulation and fibrinolysis. Thromb Res. 2005; 116(4):345-56. PMID: 16038720.
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    128. Manco-Johnson MJ. Etiopathogenesis of pediatric thrombosis. Hematology. 2005; 10 Suppl 1:167-70. PMID: 16188663.
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    129. Journeycake JM, Manco-Johnson MJ. Thrombosis during infancy and childhood: what we know and what we do not know. Hematol Oncol Clin North Am. 2004 Dec; 18(6):1315-38, viii-ix. PMID: 15511618.
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    130. Manco-Johnson MJ, Pettersson H, Petrini P, Babyn PS, Bergstrom BM, Bradley CS, Doria AS, Feldman BM, Funk S, Hilliard P, Kilcoyne R, Lundin B, Nuss R, Rivard G, Schoenmakers MA, Van den Berg M, Wiedel J, Zourikian N, Blanchette VS. Physical therapy and imaging outcome measures in a haemophilia population treated with factor prophylaxis: current status and future directions. Haemophilia. 2004 Oct; 10 Suppl 4:88-93. PMID: 15479378.
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    131. Goldenberg NA, Knapp-Clevenger R, Manco-Johnson MJ. Elevated plasma factor VIII and D-dimer levels as predictors of poor outcomes of thrombosis in children. N Engl J Med. 2004 Sep 09; 351(11):1081-8. PMID: 15356305.
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    132. Manco-Johnson MJ, Knapp-Clevenger R. Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiency. J Pediatr Hematol Oncol. 2004 Jan; 26(1):25-7. PMID: 14707707.
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    133. Manco-Johnson M, Morrissey-Harding G, Edelman-Lewis B, Oster G, Larson P. Development and validation of a measure of disease-specific quality of life in young children with haemophilia. Haemophilia. 2004 Jan; 10(1):34-41. PMID: 14962218.
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    134. Manco-Johnson MJ, Riske B, Kasper CK. Advances in care of children with hemophilia. Semin Thromb Hemost. 2003 Dec; 29(6):585-94. PMID: 14719175.
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    135. Petäjä J, Manco-Johnson MJ. Protein C pathway in infants and children. Semin Thromb Hemost. 2003 Aug; 29(4):349-62. PMID: 14517747.
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    136. Manco-Johnson MJ. Update on treatment regimens: prophylaxis versus on-demand therapy. Semin Hematol. 2003 Jul; 40(3 Suppl 3):3-9. PMID: 14690062.
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    137. Young G, Manco-Johnson M, Gill JC, Dimichele DM, Tarantino MD, Abshire T, Nugent DJ. Clinical manifestations of the prothrombin G20210A mutation in children: a pediatric coagulation consortium study. J Thromb Haemost. 2003 May; 1(5):958-62. PMID: 12871361.
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    138. Wang M, Hays T, Balasa V, Bagatell R, Gruppo R, Grabowski EF, Valentino LA, Tsao-Wu G, Manco-Johnson MJ. Low-dose tissue plasminogen activator thrombolysis in children. J Pediatr Hematol Oncol. 2003 May; 25(5):379-86. PMID: 12759624.
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    139. Manco-Johnson MJ, Blanchette VS. North American prophylaxis studies for persons with severe haemophilia: background, rationale and design. Haemophilia. 2003 May; 9 Suppl 1:44-8; discussion 49. PMID: 12709037.
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    140. Blanchette VS, McCready M, Achonu C, Abdolell M, Rivard G, Manco-Johnson MJ. A survey of factor prophylaxis in boys with haemophilia followed in North American haemophilia treatment centres. Haemophilia. 2003 May; 9 Suppl 1:19-26; discussion 26. PMID: 12709033.
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    141. Smith AA, Jacobson LJ, Miller BI, Hathaway WE, Manco-Johnson MJ. A new euglobulin clot lysis assay for global fibrinolysis. Thromb Res. 2003; 112(5-6):329-37. PMID: 15041279.
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    142. Brenner BR, Nowak-G?ttl U, Kosch A, Manco-Johnson M, Laposata M. Diagnostic studies for thrombophilia in women on hormonal therapy and during pregnancy, and in children. Arch Pathol Lab Med. 2002 Nov; 126(11):1296-303. PMID: 12421137.
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    143. Manco-Johnson MJ, Nuss R, Lear J, Wiedel J, Geraghty SJ, Hacker MR, Funk S, Kilcoyne RF, Murphy J. 32P Radiosynoviorthesis in children with hemophilia. J Pediatr Hematol Oncol. 2002 Oct; 24(7):534-9. PMID: 12368689.
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    144. Manco-Johnson MJ, Jacobson LJ, Hacker MR, Townsend SF, Murphy J, Hay W. Development of coagulation regulatory proteins in the fetal and neonatal lamb. Pediatr Res. 2002 Oct; 52(4):580-8. PMID: 12357054.
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    145. Goedert JJ, Eyster ME, Lederman MM, Mandalaki T, De Moerloose P, White GC, Angiolillo AL, Luban NL, Sherman KE, Manco-Johnson M, Preiss L, Leissinger C, Kessler CM, Cohen AR, DiMichele D, Hilgartner MW, Aledort LM, Kroner BL, Rosenberg PS, Hatzakis A. End-stage liver disease in persons with hemophilia and transfusion-associated infections. Blood. 2002 Sep 01; 100(5):1584-9. PMID: 12176875.
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    146. Manco-Johnson MJ, Grabowski EF, Hellgreen M, Kemahli AS, Massicotte MP, Muntean W, Peters M, Schlegel N, Wang M, Nowak-G?ttl U. Recommendations for tPA thrombolysis in children. On behalf of the Scientific Subcommittee on Perinatal and Pediatric Thrombosis of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis. Thromb Haemost. 2002 Jul; 88(1):157-8. PMID: 12152658.
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    147. Manco-Johnson MJ, Grabowski EF, Hellgreen M, Kemahli AS, Massicotte MP, Muntean W, Peters M, Nowak-G?ttl U. Laboratory testing for thrombophilia in pediatric patients. On behalf of the Subcommittee for Perinatal and Pediatric Thrombosis of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis (ISTH). Thromb Haemost. 2002 Jul; 88(1):155-6. PMID: 12152657.
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    148. Josephson C, Nuss R, Jacobson L, Hacker MR, Murphy J, Weinberg A, Manco-Johnson MJ. The varicella-autoantibody syndrome. Pediatr Res. 2001 Sep; 50(3):345-52. PMID: 11518821.
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    149. Lefkowitz JB, Nuss R, Haver T, Jacobson L, Thompson AR, Manco-Johnson M. Factor IX Denver, ASN 346-->ASP mutation resulting in a dysfunctional protein with defective factor VIIIa interaction. Thromb Haemost. 2001 Sep; 86(3):862-70. PMID: 11583320.
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    150. Hacker MR, Geraghty S, Manco-Johnson M. Barriers to compliance with prophylaxis therapy in haemophilia. Haemophilia. 2001 Jul; 7(4):392-6. PMID: 11442644.
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    151. Soucie JM, Richardson LC, Evatt BL, Linden JV, Ewenstein BM, Stein SF, Leissinger C, Manco-Johnson M, Sexauer CL. Risk factors for infection with HBV and HCV in a largecohort of hemophiliac males. Transfusion. 2001 Mar; 41(3):338-43. PMID: 11274587.
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    152. Manco-Johnson MJ, Nuss R. Thrombophilia in the infant and child. Adv Pediatr. 2001; 48:363-84. PMID: 11480763.
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    153. Manco-Johnson MJ, Nuss R, Funk S, Murphy J. Joint evaluation instruments for children and adults with haemophilia. Haemophilia. 2000 Nov; 6(6):649-57. PMID: 11122391.
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    154. Zimbelman J, Lefkowitz J, Schaeffer C, Hays T, Manco-Johnson M, Manhalter C, Nuss R. Unusual complications of warfarin therapy: skin necrosis and priapism. J Pediatr. 2000 Aug; 137(2):266-8. PMID: 10931425.
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    155. Manco-Johnson MJ, Nuss R, Jacobson LJ. Heparin neutralization is essential for accurate measurement of factor VIII activity and inhibitor assays in blood samples drawn from implanted venous access devices. J Lab Clin Med. 2000 Jul; 136(1):74-9. PMID: 10882230.
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    156. Manco-Johnson MJ, Nuss R, Hays T, Krupski W, Drose J, Manco-Johnson ML. Combined thrombolytic and anticoagulant therapy for venous thrombosis in children. J Pediatr. 2000 Apr; 136(4):446-53. PMID: 10753241.
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    157. Lefkowitz JB, Haver T, Clarke S, Jacobson L, Weller A, Nuss R, Manco-Johnson M, Hathaway WE. The prothrombin Denver patient has two different prothrombin point mutations resulting in Glu-300-->Lys and Glu-309-->Lys substitutions. Br J Haematol. 2000 Jan; 108(1):182-7. PMID: 10651742.
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    158. Nuss R, Jacobson L, Hathaway WE, Manco-Johnson M. Evidence for antiphospholipid antibodies in hemophilic children with factor VIII inhibitors. Recombinate PUP Study Group. Thromb Haemost. 1999 Nov; 82(5):1559-60. PMID: 10595659.
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    159. Baker DC, Robbe SL, Jacobson L, Manco-Johnson MJ, Holler L, Lefkowitz J. Hereditary deficiency of vitamin-K-dependent coagulation factors in Rambouillet sheep. Blood Coagul Fibrinolysis. 1999 Mar; 10(2):75-80. PMID: 10192655.
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    160. Sifontes MT, Nuss R, Hunger SP, Waters J, Jacobson LJ, Manco-Johnson M. Activated protein C resistance and the factor V Leiden mutation in children with thrombosis. Am J Hematol. 1998 Jan; 57(1):29-32. PMID: 9423813.
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    161. Sifontes MT, Nuss R, Hunger SP, Jacobson LJ, Waters J, Manco-Johnson MJ. Correlation between the functional assay for activated protein C resistance and factor V Leiden in the neonate. Pediatr Res. 1997 Dec; 42(6):776-8. PMID: 9396556.
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    162. Manco-Johnson MJ. Disorders of hemostasis in childhood: risk factors for venous thromboembolism. Thromb Haemost. 1997 Jul; 78(1):710-4. PMID: 9198244.
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    163. Sifontes MT, Nuss R, Hunger SP, Wilimas J, Jacobson LJ, Manco-Johnson MJ. The factor V Leiden mutation in children with cancer and thrombosis. Br J Haematol. 1997 Mar; 96(3):484-9. PMID: 9054652.
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    164. Manco-Johnson MJ, Nuss R, Key N, Moertel C, Jacobson L, Meech S, Weinberg A, Lefkowitz J. Lupus anticoagulant and protein S deficiency in children with postvaricella purpura fulminans or thrombosis. J Pediatr. 1996 Mar; 128(3):319-23. PMID: 8774497.
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    165. Sifontes MT, Nuss R, Jacobson LJ, Griffin JH, Manco-Johnson MJ. Thrombosis in otherwise well children with the factor V Leiden mutation. J Pediatr. 1996 Mar; 128(3):324-8. PMID: 8774498.
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    166. Nuss R, Hays T, Manco-Johnson M. Childhood thrombosis. Pediatrics. 1995 Aug; 96(2 Pt 1):291-4. PMID: 7630687.
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    167. David M, Manco-Johnson M, Andrew M. Diagnosis and treatment of venous thromboembolism in children and adolescents. On behalf of the Subcommittee on Perinatal Haemostasis of the Scientific and Standardization Committee of the ISTH. Thromb Haemost. 1995 Aug; 74(2):791-2. PMID: 8585023.
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    168. Manco-Johnson MJ, Spedale S, Peters M, Townsend SF, Jacobson LJ, Christian J, Krugman SD, Hay WW, Sparks JW. Identification of a unique form of protein C in the ovine fetus: developmentally linked transition to the adult form. Pediatr Res. 1995 Mar; 37(3):365-72. PMID: 7784146.
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    169. Manco-Johnson MJ, Carver T, Jacobson LJ, Townsend SF, Hay WW. Hyperglycemia-induced hyperinsulinemia decreases maternal and fetal plasma protein C concentration during ovine gestation. Pediatr Res. 1994 Sep; 36(3):293-9. PMID: 7808824.
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    170. Nuss R, Kilcoyne R, Geraghty S, Wilkins R, Wiedel J, Manco-Johnson M. Magnetic resonance imaging visualization of hemorrhage into a suprapatellar pouch in a child with hemophilia. Am J Pediatr Hematol Oncol. 1994 May; 16(2):183-5. PMID: 8166374.
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    171. Nuss R, Hays T, Manco-Johnson M. Efficacy and safety of heparin anticoagulation for neonatal renal vein thrombosis. Am J Pediatr Hematol Oncol. 1994 May; 16(2):127-31. PMID: 8166365.
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    172. Manco-Johnson MJ, Abshire TC, Jacobson LJ, Marlar RA. Severe neonatal protein C deficiency: prevalence and thrombotic risk. J Pediatr. 1991 Nov; 119(5):793-8. PMID: 1834822.
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    173. Mahasandana C, Suvatte V, Chuansumrit A, Marlar RA, Manco-Johnson MJ, Jacobson LJ, Hathaway WE. Homozygous protein S deficiency in an infant with purpura fulminans. J Pediatr. 1990 Nov; 117(5):750-3. PMID: 2231208.
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    174. Mahasandana C, Suvatte V, Marlar RA, Manco-Johnson MJ, Jacobson LJ, Hathaway WE. Neonatal purpura fulminans associated with homozygous protein S deficiency. Lancet. 1990 Jan 06; 335(8680):61-2. PMID: 1967377.
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    175. Greffe BS, Marlar RA, Manco-Johnson MJ. Neonatal protein C: molecular composition and distribution in normal term infants. Thromb Res. 1989 Oct 01; 56(1):91-8. PMID: 2595675.
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    176. Manco-Johnson MJ, Marlar RA, Jacobson LJ, Hays T, Warady BA. Severe protein C deficiency in newborn infants. J Pediatr. 1988 Aug; 113(2):359-63. PMID: 3397801.
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    177. Sedman A, Bell P, Manco-Johnson M, Schrier R, Warady BA, Heard EO, Butler-Simon N, Gabow P. Autosomal dominant polycystic kidney disease in childhood: a longitudinal study. Kidney Int. 1987 Apr; 31(4):1000-5. PMID: 3295357.
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    178. Shapiro AD, Jacobson LJ, Armon ME, Manco-Johnson MJ, Hulac P, Lane PA, Hathaway WE. Vitamin K deficiency in the newborn infant: prevalence and perinatal risk factors. J Pediatr. 1986 Oct; 109(4):675-80. PMID: 3761086.
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    179. Sambrano JE, Jacobson LJ, Reeve EB, Manco-Johnson MJ, Hathaway WE. Abnormal antithrombin III with defective serine protease binding (antithrombin III "Denver"). J Clin Invest. 1986 Mar; 77(3):887-93. PMID: 3512602.
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