 Dishevelled Proteins
"Dishevelled Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.
| Descriptor ID |
D000072261
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| MeSH Number(s) |
D12.644.360.024.288 D12.776.157.057.028 D12.776.476.024.330
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dishevelled Proteins".
Below are MeSH descriptors whose meaning is more specific than "Dishevelled Proteins".
This graph shows the total number of publications written about "Dishevelled Proteins" by people in this website by year, and whether "Dishevelled Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dishevelled Proteins" by people in Profiles.
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Bikkavilli RK, Avasarala S, Vanscoyk M, Sechler M, Kelley N, Malbon CC, Winn RA. Dishevelled3 is a novel arginine methyl transferase substrate. Sci Rep. 2012; 2:805.
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Vladar EK, Axelrod JD. Dishevelled links basal body docking and orientation in ciliated epithelial cells. Trends Cell Biol. 2008 Nov; 18(11):517-20.
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Roffers-Agarwal J, Xanthos JB, Miller JR. Regulation of actin cytoskeleton architecture by Eps8 and Abi1. BMC Cell Biol. 2005 Oct 14; 6:36.
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