 Rapamycin-Insensitive Companion of mTOR Protein
"Rapamycin-Insensitive Companion of mTOR Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An adaptor protein subunit of MTORC2 COMPLEX. It functions as a structural component and is phosphorylated by RIBOSOMAL PROTEIN S6 KINASES, integrating signals for cell growth and proliferation, especially during embryonic development.
| Descriptor ID |
D000076226
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| MeSH Number(s) |
D05.500.356.500 D08.811.913.696.620.682.700.931.750.500 D12.644.360.024.323 D12.776.157.057.156 D12.776.476.024.411 D12.776.476.925.750.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Rapamycin-Insensitive Companion of mTOR Protein".
Below are MeSH descriptors whose meaning is more specific than "Rapamycin-Insensitive Companion of mTOR Protein".
This graph shows the total number of publications written about "Rapamycin-Insensitive Companion of mTOR Protein" by people in this website by year, and whether "Rapamycin-Insensitive Companion of mTOR Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2012 | 0 | 4 | 4 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 3 | 3 | | 2015 | 0 | 4 | 4 | | 2016 | 0 | 2 | 2 | | 2017 | 1 | 1 | 2 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Rapamycin-Insensitive Companion of mTOR Protein" by people in Profiles.
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Rosario FJ, Gupta MB, Myatt L, Powell TL, Glenn JP, Cox L, Jansson T. Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis. Sci Rep. 2019 01 22; 9(1):246.
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Grier MD, West KL, Kelm ND, Fu C, Does MD, Parker B, McBrier E, Lagrange AH, Ess KC, Carson RP. Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination. PLoS One. 2017; 12(11):e0188417.
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Morrison Joly M, Williams MM, Hicks DJ, Jones B, Sanchez V, Young CD, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS. Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis. Breast Cancer Res. 2017 Jun 30; 19(1):74.
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Rosario FJ, Powell TL, Jansson T. Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-a and the RFC. Sci Rep. 2016 08 26; 6:31705.
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Morrison Joly M, Hicks DJ, Jones B, Sanchez V, Estrada MV, Young C, Williams M, Rexer BN, Sarbassov dos D, Muller WJ, Brantley-Sieders D, Cook RS. Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers. Cancer Res. 2016 08 15; 76(16):4752-64.
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Damerill I, Biggar KK, Abu Shehab M, Li SS, Jansson T, Gupta MB. Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition. Mol Endocrinol. 2016 Feb; 30(2):201-16.
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Kelm ND, West KL, Carson RP, Gochberg DF, Ess KC, Does MD. Evaluation of diffusion kurtosis imaging in ex vivo hypomyelinated mouse brains. Neuroimage. 2016 Jan 01; 124(Pt A):612-626.
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Morrison MM, Young CD, Wang S, Sobolik T, Sanchez VM, Hicks DJ, Cook RS, Brantley-Sieders DM. mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis. PLoS Genet. 2015 Jul; 11(7):e1005291.
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Malkani N, Jansson T, Gupta MB. IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway. Mol Cell Endocrinol. 2015 Sep 05; 412:182-95.
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Ravichandran K, Zafar I, He Z, Doctor RB, Moldovan R, Mullick AE, Edelstein CL. An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2. Hum Mol Genet. 2014 Sep 15; 23(18):4919-31.
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