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Lydia R. Heasley

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

    Collapse Research 
    Collapse research activities and funding
    R00GM134193     (HEASLEY, LYDIA RENE)Apr 1, 2020 - Jul 31, 2025
    NIH
    Properties and mechanisms of punctuated genome instability
    Role: Principal Investigator
    K99GM134193     (HEASLEY, LYDIA RENE)Apr 1, 2020 - Jul 31, 2022
    NIH
    Properties and Mechanisms of Punctuated Genome Instability
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Heasley LR, Argueso JL. Bursts of Genomic Instability Potentiate Phenotypic and Genomic Diversification in Saccharomyces cerevisiae. Front Genet. 2022; 13:912851. PMID: 35783258.
      View in: PubMed
    2. Heasley LR, Argueso JL. Genomic characterization of a wild diploid isolate of Saccharomyces cerevisiae reveals an extensive and dynamic landscape of structural variation. Genetics. 2022 03 03; 220(3). PMID: 34791219.
      View in: PubMed
    3. Heasley LR, Sampaio NMV, Argueso JL. Genome-Wide Analysis of Mitotic Recombination in Budding Yeast. Methods Mol Biol. 2021; 2153:201-219. PMID: 32840782.
      View in: PubMed
    4. Heasley LR, Singer E, Cooperman BJ, McMurray MA. Saccharomyces spores are born prepolarized to outgrow away from spore-spore connections and penetrate the ascus wall. Yeast. 2021 01; 38(1):90-101. PMID: 33238051.
      View in: PubMed
    5. Heasley LR, Sampaio NMV, Argueso JL. Systemic and rapid restructuring of the genome: a new perspective on punctuated equilibrium. Curr Genet. 2021 Feb; 67(1):57-63. PMID: 33159552.
      View in: PubMed
    6. Sampaio NMV, Ajith VP, Watson RA, Heasley LR, Chakraborty P, Rodrigues-Prause A, Malc EP, Mieczkowski PA, Nishant KT, Argueso JL. Characterization of systemic genomic instability in budding yeast. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28221-28231. PMID: 33106418.
      View in: PubMed
    7. Heasley LR, Watson RA, Argueso JL. Punctuated Aneuploidization of the Budding Yeast Genome. Genetics. 2020 09; 216(1):43-50. PMID: 32753390.
      View in: PubMed
    8. Heasley LR, DeLuca JG, Markus SM. Effectors of the spindle assembly checkpoint are confined within the nucleus of Saccharomyces cerevisiae. Biol Open. 2019 Jun 12; 8(6). PMID: 31182632.
      View in: PubMed
    9. Heasley LR, Markus SM, DeLuca JG. "Wait anaphase" signals are not confined to the mitotic spindle. Mol Biol Cell. 2017 May 01; 28(9):1186-1194. PMID: 28298492.
      View in: PubMed
    10. Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017 Jan 16; 6(1):e287. PMID: 28092369.
      View in: PubMed
    11. Schaefer RM, Heasley LR, Odde DJ, McMurray MA. Kinetic partitioning during de novo septin filament assembly creates a critical G1 "window of opportunity" for mutant septin function. Cell Cycle. 2016 Sep 16; 15(18):2441-53. PMID: 27398993.
      View in: PubMed
    12. Heasley LR, McMurray MA. Small molecule perturbations of septins. Methods Cell Biol. 2016; 136:311-9. PMID: 27473917.
      View in: PubMed
    13. Garcia G, Finnigan GC, Heasley LR, Sterling SM, Aggarwal A, Pearson CG, Nogales E, McMurray MA, Thorner J. Assembly, molecular organization, and membrane-binding properties of development-specific septins. J Cell Biol. 2016 Feb 29; 212(5):515-29. PMID: 26929450.
      View in: PubMed
    14. Heasley LR, McMurray MA. Roles of septins in prospore membrane morphogenesis and spore wall assembly in Saccharomyces cerevisiae. Mol Biol Cell. 2016 Feb 01; 27(3):442-50. PMID: 26680739.
      View in: PubMed
    15. Dahl KD, Sankaran DG, Bayless BA, Pinter ME, Galati DF, Heasley LR, Giddings TH, Pearson CG. A Short CEP135 Splice Isoform Controls Centriole Duplication. Curr Biol. 2015 Oct 05; 25(19):2591-6. PMID: 26412126.
      View in: PubMed
    16. Kleczko EK, Kim J, Keysar SB, Heasley LR, Eagles JR, Simon M, Marshall ME, Singleton KR, Jimeno A, Tan AC, Heasley LE. An Inducible TGF-?2-TGF?R Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases. PLoS One. 2015; 10(5):e0123600. PMID: 25946135.
      View in: PubMed
    17. Heasley LR, Garcia G, McMurray MA. Off-target effects of the septin drug forchlorfenuron on nonplant eukaryotes. Eukaryot Cell. 2014 Nov; 13(11):1411-20. PMID: 25217460.
      View in: PubMed
    18. Ware KE, Marshall ME, Heasley LR, Marek L, Hinz TK, Hercule P, Helfrich BA, Doebele RC, Heasley LE. Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression. PLoS One. 2010 Nov 29; 5(11):e14117. PMID: 21152424.
      View in: PubMed
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