 Intrinsically Disordered Proteins
"Intrinsically Disordered Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.
| Descriptor ID |
D064267
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| MeSH Number(s) |
D12.776.481
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Intrinsically Disordered Proteins".
Below are MeSH descriptors whose meaning is more specific than "Intrinsically Disordered Proteins".
This graph shows the total number of publications written about "Intrinsically Disordered Proteins" by people in this website by year, and whether "Intrinsically Disordered Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 1 | 2 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 1 | 2 | | 2017 | 1 | 2 | 3 | | 2018 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 2 | 2 | 4 | | 2022 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 | | 2024 | 2 | 3 | 5 | | 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Intrinsically Disordered Proteins" by people in Profiles.
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Becht DC, Selvam K, Lachance C, C?t? V, Li K, Nguyen MC, Pareek A, Shi X, Wen H, Blanco MA, C?t? J, Kutateladze TG. A multivalent engagement of ENL with MOZ. Nat Struct Mol Biol. 2025 Apr; 32(4):709-718.
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Palacio M, Taatjes DJ. Transcription regulation through selective partitioning: Weak interactions with a strong foundation. Mol Cell. 2024 Sep 19; 84(18):3375-3377.
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Kletzien OA, Wuttke DS, Batey RT. The RNA-binding Selectivity of the RGG/RG Motifs of hnRNP U is Abolished by Elements Within the C-terminal Intrinsically Disordered Region. J Mol Biol. 2024 Sep 15; 436(18):168702.
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Zhao H, Li J, Xiang Y, Malik S, Vartak SV, Veronezi GMB, Young N, Riney M, Kalchschmidt J, Conte A, Jung SK, Ramachandran S, Roeder RG, Shi Y, Casellas R, Asturias FJ. An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II. Mol Cell. 2024 Jul 25; 84(14):2648-2664.e10.
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Pandi B, Brenman S, Black A, Ng DCM, Lau E, Lam MPY. Tissue Usage Preference and Intrinsically Disordered Region Remodeling of Alternative Splicing Derived Proteoforms in the Heart. J Proteome Res. 2024 Aug 02; 23(8):3161-3173.
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Ramirez DA, Hough LE, Shirts MR. Coiled-coil domains are sufficient to drive liquid-liquid phase separation in protein models. Biophys J. 2024 03 19; 123(6):703-717.
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Ram?ak M, Ramirez DA, Hough LE, Shirts MR, Vidmar S, Eler?ic Filipic K, Anderluh G, Jerala R. Programmable de novo designed coiled coil-mediated phase separation in mammalian cells. Nat Commun. 2023 12 02; 14(1):7973.
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Ibrahim AY, Khaodeuanepheng NP, Amarasekara DL, Correia JJ, Lewis KA, Fitzkee NC, Hough LE, Whitten ST. Intrinsically disordered regions that drive phase separation form a robustly distinct protein class. J Biol Chem. 2023 01; 299(1):102801.
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Morgan GJ. Transient disorder along pathways to amyloid. Biophys Chem. 2022 02; 281:106711.
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Yahya G, P?rez AP, Mendoza MB, Parisi E, Moreno DF, Art?s MH, Gallego C, Aldea M. Stress granules display bistable dynamics modulated by Cdk. J Cell Biol. 2021 03 01; 220(3).
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