 Interferon Regulatory Factor-3
"Interferon Regulatory Factor-3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An interferon regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral infection. PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA, and activates transcription.
| Descriptor ID |
D050838
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| MeSH Number(s) |
D12.644.360.024.302.374 D12.776.157.057.050.374 D12.776.260.504.374 D12.776.476.024.385.374 D12.776.744.562 D12.776.930.332.374
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| Concept/Terms |
Interferon Regulatory Factor-3- Interferon Regulatory Factor-3
- Interferon Regulatory Factor 3
- IRF-3 Transcription Factor
- IRF 3 Transcription Factor
- Transcription Factor, IRF-3
- IFN-Regulatory Factor 3
- IFN Regulatory Factor 3
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Below are MeSH descriptors whose meaning is more general than "Interferon Regulatory Factor-3".
Below are MeSH descriptors whose meaning is more specific than "Interferon Regulatory Factor-3".
This graph shows the total number of publications written about "Interferon Regulatory Factor-3" by people in this website by year, and whether "Interferon Regulatory Factor-3" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2004 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2009 | 0 | 2 | 2 | | 2010 | 0 | 2 | 2 | | 2011 | 1 | 1 | 2 | | 2012 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interferon Regulatory Factor-3" by people in Profiles.
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McKenna S, Burey T, Sandoval J, Nguyen L, Castro O, Gudipati S, Gonzalez J, El Kasmi KC, Wright CJ. Immunotolerant p50/NF?B Signaling and Attenuated Hepatic IFNß Expression Increases Neonatal Sensitivity to Endotoxemia. Front Immunol. 2018; 9:2210.
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Haist KC, Burrack KS, Davenport BJ, Morrison TE. Inflammatory monocytes mediate control of acute alphavirus infection in mice. PLoS Pathog. 2017 12; 13(12):e1006748.
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Nocera DA, Roselli E, Araya P, Nuñez NG, Lienenklaus S, Jablonska J, Weiss S, Gatti G, Brinkmann MM, Kröger A, Morón G, Maccioni M. In Vivo Visualizing the IFN-ß Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration. J Immunol. 2016 Mar 15; 196(6):2860-9.
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Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E710-7.
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Klarquist J, Hennies CM, Lehn MA, Reboulet RA, Feau S, Janssen EM. STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells. J Immunol. 2014 Dec 15; 193(12):6124-34.
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Schuessler A, Funk A, Lazear HM, Cooper DA, Torres S, Daffis S, Jha BK, Kumagai Y, Takeuchi O, Hertzog P, Silverman R, Akira S, Barton DJ, Diamond MS, Khromykh AA. West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response. J Virol. 2012 May; 86(10):5708-18.
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Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 2011 Sep 01; 187(5):2595-601.
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Boudreau JE, Stephenson KB, Wang F, Ashkar AA, Mossman KL, Lenz LL, Rosenthal KL, Bramson JL, Lichty BD, Wan Y. IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells. Cancer Res. 2011 Apr 01; 71(7):2497-506.
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Jin L, Lenz LL, Cambier JC. Cellular reactive oxygen species inhibit MPYS induction of IFNß. PLoS One. 2010 Dec 10; 5(12):e15142.
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Cruz CC, Suthar MS, Montgomery SA, Shabman R, Simmons J, Johnston RE, Morrison TE, Heise MT. Modulation of type I IFN induction by a virulence determinant within the alphavirus nsP1 protein. Virology. 2010 Mar 30; 399(1):1-10.
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