 Mary Heather Knowles
| Title | Asst Professor |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-MED |
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 Biography | 2017 | Award for Excellence, Division of Hematology, University of Colorado SOM | | 2020 | Inpatient APP of the Year, Division of Hematology, University of Colorado SOM |
Overview I’m a Physician Assistant (PA) and Assistant Professor at the University of Colorado School of Medicine. I began my career as a research immunologist studying the pathophysiology of autoimmune disorders and infections. I left the laboratory after many years to pursue a clinical career as a PA, treating patients with blood cancers. My research and clinical focus are to reduce the impact that treatment-related complications from chimeric antigen receptor (CAR)-T cell therapy or stem cell transplant have on the patient’s experience during their journey for a cure.
Bibliographic
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Knowles H, Li Y, Perraud AL. The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation. Immunol Res. 2013 Mar; 55(1-3):241-8. PMID: 22975787.
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Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. J Immunol. 2013 Mar 15; 190(6):2835-43. PMID: 23378430.
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Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 2011 Sep 01; 187(5):2595-601. PMID: 21813776.
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Knowles H, Heizer JW, Li Y, Chapman K, Ogden CA, Andreasen K, Shapland E, Kucera G, Mogan J, Humann J, Lenz LL, Morrison AD, Perraud AL. Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11578-83. PMID: 21709234.
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Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem. 2005 Feb 18; 280(7):6138-48. PMID: 15561722.
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Perraud AL, Knowles HM, Schmitz C. Novel aspects of signaling and ion-homeostasis regulation in immunocytes. The TRPM ion channels and their potential role in modulating the immune response. Mol Immunol. 2004 Jul; 41(6-7):657-73. PMID: 15220002.
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Cipriani B, Chen L, Hiromatsu K, Knowles H, Raine CS, Battistini L, Porcelli SA, Brosnan CF. Upregulation of group 1 CD1 antigen presenting molecules in guinea pigs with experimental autoimmune encephalomyelitis: an immunohistochemical study. Brain Pathol. 2003 Jan; 13(1):1-9. PMID: 12580540.
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Cipriani B, Knowles H, Chen L, Battistini L, Brosnan CF. Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens. J Immunol. 2002 Nov 15; 169(10):5761-70. PMID: 12421956.
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Cipriani B, Borsellino G, Knowles H, Tramonti D, Cavaliere F, Bernardi G, Battistini L, Brosnan CF. Curcumin inhibits activation of Vgamma9Vdelta2 T cells by phosphoantigens and induces apoptosis involving apoptosis-inducing factor and large scale DNA fragmentation. J Immunol. 2001 Sep 15; 167(6):3454-62. PMID: 11544338.
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Downen M, Belkowski S, Knowles H, Cardillo M, Prystowsky MB. Developmental expression of voltage-gated potassium channel beta subunits. Brain Res Dev Brain Res. 1999 Oct 20; 117(1):71-80. PMID: 10536234.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 1999 | 1 | | 2001 | 1 | | 2002 | 1 | | 2003 | 1 | | 2004 | 2 | | 2011 | 2 | | 2013 | 2 |
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