Asialoglycoproteins
"Asialoglycoproteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.
| Descriptor ID |
D001212
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| MeSH Number(s) |
D12.776.395.140
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Asialoglycoproteins".
Below are MeSH descriptors whose meaning is more specific than "Asialoglycoproteins".
This graph shows the total number of publications written about "Asialoglycoproteins" by people in this website by year, and whether "Asialoglycoproteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
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Below are the most recent publications written about "Asialoglycoproteins" by people in Profiles.
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Coughlan CM, Burger PG, Berger EG, Breen KC. The biochemical consequences of alpha2,6(N) sialyltransferase induction by dexamethasone on sialoglycoprotein expression in the rat H411e hepatoma cell line. FEBS Lett. 1997 Aug 18; 413(2):389-93.
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Bader A, Reimer P, Knop E, B?ker K, Christians U, Weissleder R, Sewing KF. An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents. Magn Reson Imaging. 1995; 13(7):991-1002.
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Cumming DA, Hellerqvist CG, Harris-Brandts M, Michnick SW, Carver JP, Bendiak B. Structures of asparagine-linked oligosaccharides of the glycoprotein fetuin having sialic acid linked to N-acetylglucosamine. Biochemistry. 1989 Jul 25; 28(15):6500-12.