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Aaron W. Michels

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BDC Adult

    Collapse Research 
    Collapse research activities and funding
    R01DK108868     (MICHELS, AARON W)Jan 11, 2017 - Mar 31, 2027
    NIH
    Insulin Specific T Cell Response Shaped by Diabetes Protective MHC Class II Molecules
    Role: Principal Investigator
    DP3DK110845     (MICHELS, AARON W)Aug 1, 2016 - Jul 31, 2020
    NIH
    Insulin Specific T and B cells in Type 1 Diabetes
    Role: Principal Investigator
    R01DK099317     (MICHELS, AARON W;NAKAYAMA, MAKI)Aug 20, 2013 - May 31, 2024
    NIH
    Autoantigens targeted by CD8 T cells in type 1 diabetes: from islets to blood
    Role: Co-Principal Investigator
    R56DK099317     (NAKAYAMA, MAKI)Aug 20, 2013 - May 31, 2020
    NIH
    Autoantigens targeted by CD8 T cells in type 1 diabetes: from islets to blood
    Role: Co-Principal Investigator
    K08DK095995     (MICHELS, AARON W)Jul 1, 2012 - Apr 30, 2017
    NIH
    Small Molecules Targeting Allele Specific MHC Class II Presentation
    Role: Principal Investigator
    R01DK032083     (MICHELS, AARON W)Jul 15, 1982 - Mar 31, 2026
    NIH
    Multiple Autoantigens, Multiple Epitopes of Type 1 Diabetes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Akturk HK, Michel K, Couts K, Karakus KE, Robinson W, Michels A. Routine Blood Glucose Monitoring Does Not Predict Onset of Immune Checkpoint Inhibitor-Induced Type 1 Diabetes. Diabetes Care. 2024 Mar 01; 47(3):e29-e30. PMID: 38232313.
      View in: PubMed
    2. Mitchell AM, Baschal EE, McDaniel KA, Fleury T, Choi H, Pyle L, Yu L, Rewers MJ, Nakayama M, Michels AW. Tracking DNA-based antigen-specific T cell receptors during progression to type 1 diabetes. Sci Adv. 2023 Dec 08; 9(49):eadj6975. PMID: 38064552.
      View in: PubMed
    3. Wenzlau JM, Gu Y, Michels A, Rewers M, Haskins K, Yu L. Identification of Autoantibodies to a Hybrid Insulin Peptide in Type 1 Diabetes. Diagnostics (Basel). 2023 Sep 04; 13(17). PMID: 37685398.
      View in: PubMed
    4. Jia X, Dong F, Pyle L, Michels AW, Yu L, Rewers M. Similar Time Course of Humoral Response to SARS-CoV-2 mRNA Vaccines in People With and Without Type 1 Diabetes. Diabetes Technol Ther. 2023 07; 25(7):492-496. PMID: 36989496.
      View in: PubMed
    5. Mandel-Brehm C, Vazquez SE, Liverman C, Cheng M, Quandt Z, Kung AF, Parent A, Miao B, Disse E, Cugnet-Anceau C, Dalle S, Orlova E, Frolova E, Alba D, Michels A, Oftedal BE, Lionakis MS, Husebye ES, Agarwal AK, Li X, Zhu C, Li Q, Oral E, Brown R, Anderson MS, Garg A, DeRisi JL. Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy. Diabetes. 2023 01 01; 72(1):59-70. PMID: 35709010.
      View in: PubMed
    6. Akturk HK, Couts KL, Baschal EE, Karakus KE, Van Gulick RJ, Turner JA, Pyle L, Robinson WA, Michels AW. Analysis of Human Leukocyte Antigen DR Alleles, Immune-Related Adverse Events, and Survival Associated With Immune Checkpoint Inhibitor Use Among Patients With Advanced Malignant Melanoma. JAMA Netw Open. 2022 12 01; 5(12):e2246400. PMID: 36512357.
      View in: PubMed
    7. Triolo TM, Matuschek JQ, Castro-Gutierrez R, Shilleh AH, Williams SPM, Hansen MS, McDaniel K, Barra JM, Michels A, Russ HA. Stem-Cell-Derived ?-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity. Cells. 2022 Nov 30; 11(23). PMID: 36497105.
      View in: PubMed
    8. Mitchell AM, Baschal EE, McDaniel KA, Simmons KM, Pyle L, Waugh K, Steck AK, Yu L, Gottlieb PA, Rewers MJ, Nakayama M, Michels AW. Temporal development of T cell receptor repertoires during childhood in health and disease. JCI Insight. 2022 09 22; 7(18). PMID: 35998036.
      View in: PubMed
    9. Mitchell AM, Michels AW. Self-Antigens Targeted by Regulatory T Cells in Type 1 Diabetes. Int J Mol Sci. 2022 Mar 15; 23(6). PMID: 35328581.
      View in: PubMed
    10. Michels AW, Redondo MJ, Atkinson MA. The pathogenesis, natural history, and treatment of type 1 diabetes: time (thankfully) does not stand still. Lancet Diabetes Endocrinol. 2022 02; 10(2):90-92. PMID: 34951951.
      View in: PubMed
    11. Nakayama M, Michels AW. Using the T Cell Receptor as a Biomarker in Type 1 Diabetes. Front Immunol. 2021; 12:777788. PMID: 34868047.
      View in: PubMed
    12. Anderson AM, Landry LG, Alkanani AA, Pyle L, Powers AC, Atkinson MA, Mathews CE, Roep BO, Michels AW, Nakayama M. Human islet T cells are highly reactive to preproinsulin in type 1 diabetes. Proc Natl Acad Sci U S A. 2021 10 12; 118(41). PMID: 34611019.
      View in: PubMed
    13. Castro-Gutierrez R, Alkanani A, Mathews CE, Michels A, Russ HA. Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition. Front Endocrinol (Lausanne). 2021; 12:707881. PMID: 34305820.
      View in: PubMed
    14. Landry LG, Anderson AM, Russ HA, Yu L, Kent SC, Atkinson MA, Mathews CE, Michels AW, Nakayama M. Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors. Front Endocrinol (Lausanne). 2021; 12:622647. PMID: 33841327.
      View in: PubMed
    15. Jia X, Gesualdo P, Geno Rasmussen C, Alkanani AA, He L, Dong F, Rewers MJ, Michels AW, Yu L. Prevalence of SARS-CoV-2 Antibodies in Children and Adults with Type 1 Diabetes. Diabetes Technol Ther. 2021 07; 23(7):517-521. PMID: 33544017.
      View in: PubMed
    16. Mitchell AM, Alkanani AA, McDaniel KA, Pyle L, Waugh K, Steck AK, Nakayama M, Yu L, Gottlieb PA, Rewers MJ, Michels AW. T-cell responses to hybrid insulin peptides prior to type 1 diabetes development. Proc Natl Acad Sci U S A. 2021 02 09; 118(6). PMID: 33542101.
      View in: PubMed
    17. Mitchell AM, Michels AW. T cell receptor sequencing in autoimmunity. J Life Sci (Westlake Village). 2020 Dec; 2(4):38-58. PMID: 33364626.
      View in: PubMed
    18. Gottlieb PA, Michels AW. Advances in Diabetes Treatment - Once-Weekly Insulin. N Engl J Med. 2020 11 26; 383(22):2171-2172. PMID: 33252874.
      View in: PubMed
    19. Akturk HK, Michels AW. Adverse events associated with immune checkpoint inhibitors: a new era in autoimmune diabetes. Curr Opin Endocrinol Diabetes Obes. 2020 08; 27(4):187-193. PMID: 32618630.
      View in: PubMed
    20. Simmons KM, Mitchell AM, Alkanani AA, McDaniel KA, Baschal EE, Armstrong T, Pyle L, Yu L, Michels AW. Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02. Diabetes. 2020 08; 69(8):1763-1769. PMID: 32439825.
      View in: PubMed
    21. Mann SE, Zhou Z, Landry LG, Anderson AM, Alkanani AK, Fischer J, Peakman M, Mallone R, Campbell K, Michels AW, Nakayama M. Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System. Front Immunol. 2020; 11:633. PMID: 32328071.
      View in: PubMed
    22. Akturk HK, Michels AW. Immune Checkpoint Inhibitor-Induced Type 1 Diabetes: An Underestimated Risk. Mayo Clin Proc. 2020 03; 95(3):614-615. PMID: 32138890.
      View in: PubMed
    23. Gu Y, Zhao Z, Waugh K, Miao D, Jia X, Cheng J, Michels A, Rewers M, Yang T, Yu L. High-throughput multiplexed autoantibody detection to screen type 1 diabetes and multiple autoimmune diseases simultaneously. EBioMedicine. 2019 Sep; 47:365-372. PMID: 31447394.
      View in: PubMed
    24. Simmons KM, Youngkin E, Alkanani A, Miao D, McDaniel K, Yu L, Michels AW. Screening children for type 1 diabetes-associated antibodies at community health fairs. Pediatr Diabetes. 2019 11; 20(7):909-914. PMID: 31376227.
      View in: PubMed
    25. Pan RY, Chu MT, Wang CW, Lee YS, Lemonnier F, Michels AW, Schutte R, Ostrov DA, Chen CB, Phillips EJ, Mallal SA, Mockenhaupt M, Bell?n T, Tassaneeyakul W, White KD, Roujeau JC, Chung WH, Hung SI. Identification of drug-specific public TCR driving severe cutaneous adverse reactions. Nat Commun. 2019 08 08; 10(1):3569. PMID: 31395875.
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    26. Akturk HK, Kahramangil D, Sarwal A, Hoffecker L, Murad MH, Michels AW. Immune checkpoint inhibitor-induced Type 1 diabetes: a systematic review and meta-analysis. Diabet Med. 2019 09; 36(9):1075-1081. PMID: 31199005.
      View in: PubMed
    27. Baker RL, Rihanek M, Hohenstein AC, Nakayama M, Michels A, Gottlieb PA, Haskins K, Delong T. Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes. Diabetes. 2019 09; 68(9):1830-1840. PMID: 31175101.
      View in: PubMed
    28. Acevedo-Calado MJ, Pietropaolo SL, Morran MP, Schnell S, Vonberg AD, Verge CF, Gianani R, Becker DJ, Huang S, Greenbaum CJ, Yu L, Davidson HW, Michels AW, Rich SS, Pietropaolo M. Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes. Diabetes. 2019 09; 68(9):1819-1829. PMID: 31167877.
      View in: PubMed
    29. Ahmed R, Omidian Z, Giwa A, Cornwell B, Majety N, Bell DR, Lee S, Zhang H, Michels A, Desiderio S, Sadegh-Nasseri S, Rabb H, Gritsch S, Suva ML, Cahan P, Zhou R, Jie C, Donner T, Hamad ARA. A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen. Cell. 2019 05 30; 177(6):1583-1599.e16. PMID: 31150624.
      View in: PubMed
    30. Ostrov DA, Gottlieb PA, Michels AW. Rationally designed small molecules to prevent type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2019 04; 26(2):90-95. PMID: 30694829.
      View in: PubMed
    31. Akturk HK, Michels AW. Adverse Events Associated With Immune Checkpoint Inhibitors. JAMA. 2019 03 26; 321(12):1219. PMID: 30912828.
      View in: PubMed
    32. Nakayama M, Michels AW. Determining Antigen Specificity of Human Islet Infiltrating T Cells in Type 1 Diabetes. Front Immunol. 2019; 10:365. PMID: 30906293.
      View in: PubMed
    33. Akturk HK, Alkanani A, Zhao Z, Yu L, Michels AW. PD-1 Inhibitor Immune-Related Adverse Events in Patients With Preexisting Endocrine Autoimmunity. J Clin Endocrinol Metab. 2018 10 01; 103(10):3589-3592. PMID: 30124874.
      View in: PubMed
    34. Redondo MJ, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth JM, Atkinson MA, Pugliese A, Geyer S. Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes. Diabetes Care. 2018 12; 41(12):2480-2486. PMID: 30275285.
      View in: PubMed
    35. Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M. Development of T cell lines sensitive to antigen stimulation. J Immunol Methods. 2018 11; 462:65-73. PMID: 30165064.
      View in: PubMed
    36. Castro-Gutierrez R, Michels AW, Russ HA. ? Cell replacement: improving on the design. Curr Opin Endocrinol Diabetes Obes. 2018 08; 25(4):251-257. PMID: 29846237.
      View in: PubMed
    37. Michels AW, Gottlieb PA. Learning From Past Failures of Oral Insulin Trials. Diabetes. 2018 07; 67(7):1211-1215. PMID: 29934364.
      View in: PubMed
    38. Ostrov DA, Alkanani A, McDaniel KA, Case S, Baschal EE, Pyle L, Ellis S, P?llinger B, Seidl KJ, Shah VN, Garg SK, Atkinson MA, Gottlieb PA, Michels AW. Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes. J Clin Invest. 2018 05 01; 128(5):1888-1902. PMID: 29438107.
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    39. Akturk HK, Michels AW. Adverse Events Associated with Immune Checkpoint Blockade. N Engl J Med. 2018 03 22; 378(12):1163-4. PMID: 29565519.
      View in: PubMed
    40. Yeh WI, Seay HR, Newby B, Posgai AL, Moniz FB, Michels A, Mathews CE, Bluestone JA, Brusko TM. Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes. Front Immunol. 2017; 8:1313. PMID: 29123516.
      View in: PubMed
    41. Redondo MJ, Geyer S, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth J, Xu P, Pugliese A. TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes. Diabetes Care. 2018 02; 41(2):311-317. PMID: 29025879.
      View in: PubMed
    42. Kent SC, Mannering SI, Michels AW, Babon JAB. Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime". Curr Diab Rep. 2017 09 02; 17(10):95. PMID: 28864875.
      View in: PubMed
    43. Spanier JA, Sahli NL, Wilson JC, Martinov T, Dileepan T, Burrack AL, Finger EB, Blazar BR, Michels AW, Moran A, Jenkins MK, Fife BT. Increased Effector Memory Insulin-Specific CD4+ T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes. Diabetes. 2017 12; 66(12):3051-3060. PMID: 28842400.
      View in: PubMed
    44. Waugh K, Snell-Bergeon J, Michels A, Dong F, Steck AK, Frohnert BI, Norris JM, Rewers M. Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY). PLoS One. 2017; 12(4):e0174840. PMID: 28380011.
      View in: PubMed
    45. Acevedo-Calado M, James EA, Morran MP, Pietropaolo SL, Ouyang Q, Arribas-Layton D, Songini M, Liguori M, Casu A, Auchus RJ, Huang S, Yu L, Michels A, Gianani R, Pietropaolo M. Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development. Diabetes Care. 2017 Apr; 40(4):561-568. PMID: 28174261.
      View in: PubMed
    46. Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M. Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes. Diabetes. 2017 03; 66(3):722-734. PMID: 27920090.
      View in: PubMed
    47. Simmons KM, Alkanani AK, McDaniel KA, Goyne C, Miao D, Zhao Z, Yu L, Michels AW. Islet Autoantibody Measurements from Dried Blood Spots on Filter Paper Strongly Correlate to Serum Levels. PLoS One. 2016; 11(11):e0166213. PMID: 27846247.
      View in: PubMed
    48. Simmons KM, Gottlieb PA, Michels AW. Immune Intervention and Preservation of Pancreatic Beta Cell Function in Type 1 Diabetes. Curr Diab Rep. 2016 10; 16(10):97. PMID: 27558810.
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    49. Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Perry DJ, Schultz AR, Hulme MA, Shuster JJ, Zou B, Wasserfall CH, Posgai AL, Mathews CE, Brusko TM, Atkinson MA, Schatz DA. Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes. Diabetes. 2016 Dec; 65(12):3765-3775. PMID: 27669730.
      View in: PubMed
    50. Fouts A, Pyle L, Yu L, Miao D, Michels A, Krischer J, Sosenko J, Gottlieb P, Steck AK. Do Electrochemiluminescence Assays Improve Prediction of Time to Type 1 Diabetes in Autoantibody-Positive TrialNet Subjects? Diabetes Care. 2016 Oct; 39(10):1738-44. PMID: 27456836.
      View in: PubMed
    51. Wasserfall C, Montgomery E, Yu L, Michels A, Gianani R, Pugliese A, Nierras C, Kaddis JS, Schatz DA, Bonifacio E, Atkinson MA. Validation of a rapid type 1 diabetes autoantibody screening assay for community-based screening of organ donors to identify subjects at increased risk for the disease. Clin Exp Immunol. 2016 Jul; 185(1):33-41. PMID: 27029857.
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    52. Saxon DR, McDermott MT, Michels AW. Novel Management of Insulin Autoimmune Syndrome with Rituximab and Continuous Glucose Monitoring. J Clin Endocrinol Metab. 2016 05; 101(5):1931-4. PMID: 26982011.
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    53. Zhao Z, Miao D, Michels A, Steck A, Dong F, Rewers M, Yu L. A multiplex assay combining insulin, GAD, IA-2 and transglutaminase autoantibodies to facilitate screening for pre-type 1 diabetes and celiac disease. J Immunol Methods. 2016 Mar; 430:28-32. PMID: 26809048.
      View in: PubMed
    54. Nakayama M, Simmons KM, Michels AW. Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes. Curr Diab Rep. 2015 Dec; 15(12):113. PMID: 26458384.
      View in: PubMed
    55. Simmons KM, Michels AW. Alternate Ways to Quantify Antibodies. Diabetes Technol Ther. 2015 Dec; 17(12):854-6. PMID: 26544921.
      View in: PubMed
    56. Michels AW, Ostrov DA. New approaches for predicting T cell-mediated drug reactions: A role for inducible and potentially preventable autoimmunity. J Allergy Clin Immunol. 2015 Aug; 136(2):252-7. PMID: 26254052.
      View in: PubMed
    57. Michels A, Zhang L, Khadra A, Kushner JA, Redondo MJ, Pietropaolo M. Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention. Pediatr Diabetes. 2015 Nov; 16(7):465-84. PMID: 26202050.
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    58. Simmons KM, Michels AW. Is It Time to Screen the General Population for Type 1 Diabetes? US Endocrinol. 2015; 11(1):10-6. PMID: 33312232.
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    59. Simmons KM, Michels AW. Type 1 diabetes: A predictable disease. World J Diabetes. 2015 Apr 15; 6(3):380-90. PMID: 25897349.
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    60. Nakayama M, McDaniel K, Fitzgerald-Miller L, Kiekhaefer C, Snell-Bergeon JK, Davidson HW, Rewers M, Yu L, Gottlieb P, Kappler JW, Michels A. Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4429-34. PMID: 25831495.
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    61. Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Rosenthal SM, Shuster JJ, Zou B, Brusko TM, Hulme MA, Wasserfall CH, Mathews CE, Atkinson MA, Schatz DA. Anti-thymocyte globulin/G-CSF treatment preserves ? cell function in patients with established type 1 diabetes. J Clin Invest. 2015 Jan; 125(1):448-55. PMID: 25500887.
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    62. Maturu A, Michels A, Draznin B. Multiple Disease Associations in Autoimmune Polyglandular Syndrome Type II. Endocr Pract. 2014 Dec; 20(12):e250-5. PMID: 25148815.
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    63. Simmons K, Michels AW. Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease. Rheum Dis Clin North Am. 2014 Nov; 40(4):797-811. PMID: 25437293.
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    64. Aydintug MK, Zhang L, Wang C, Liang D, Wands JM, Michels AW, Hirsch B, Day BJ, Zhang G, Sun D, Eisenbarth GS, O'Brien RL, Born WK. ?d T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation. Mol Immunol. 2014 Aug; 60(2):116-28. PMID: 24853397.
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    65. Michels A, Michels N. Addison disease: early detection and treatment principles. Am Fam Physician. 2014 Apr 01; 89(7):563-8. PMID: 24695602.
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    66. Liu E, McDaniel K, Case S, Yu L, Gerhartz B, Ostermann N, Fankhauser G, Hungerford V, Zou C, Luyten M, Seidl KJ, Michels AW. Exploring T cell reactivity to gliadin in young children with newly diagnosed celiac disease. Autoimmune Dis. 2014; 2014:927190. PMID: 24724018.
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    67. Gottlieb PA, Alkanani AK, Michels AW, Lewis EC, Shapiro L, Dinarello CA, Zipris D. a1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1? responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes. J Clin Endocrinol Metab. 2014 Aug; 99(8):E1418-26. PMID: 24527714.
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    68. Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS. Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2656-61. PMID: 24550292.
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    69. Gottlieb PA, Delong T, Baker RL, Fitzgerald-Miller L, Wagner R, Cook G, Rewers MR, Michels A, Haskins K. Chromogranin A is a T cell antigen in human type 1 diabetes. J Autoimmun. 2014 May; 50:38-41. PMID: 24239002.
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    70. Garg SK, Michels AW, Shah VN. Use of non-insulin therapies for type 1 diabetes. Diabetes Technol Ther. 2013 Nov; 15(11):901-8. PMID: 24131372.
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    71. Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014 Jan 04; 383(9911):69-82. PMID: 23890997.
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    72. Weinstock RS, Xing D, Maahs DM, Michels A, Rickels MR, Peters AL, Bergenstal RM, Harris B, Dubose SN, Miller KM, Beck RW. Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: results from the T1D Exchange clinic registry. J Clin Endocrinol Metab. 2013 Aug; 98(8):3411-9. PMID: 23760624.
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    73. Michels AW. Targeting the trimolecular complex: the pathway towards type 1 diabetes prevention. Diabetes Technol Ther. 2013 Jun; 15 Suppl 2:S2-8-S2-12. PMID: 23786298.
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    74. Michels AW. Targeting the trimolecular complex. Clin Immunol. 2013 Dec; 149(3):339-44. PMID: 23537861.
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    75. Herold KC, Gitelman SE, Willi SM, Gottlieb PA, Waldron-Lynch F, Devine L, Sherr J, Rosenthal SM, Adi S, Jalaludin MY, Michels AW, Dziura J, Bluestone JA. Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. Diabetologia. 2013 Feb; 56(2):391-400. PMID: 23086558.
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    76. Zhang L, Stadinski BD, Michels A, Kappler JW, Eisenbarth GS. Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice. Diabetes Metab Res Rev. 2011 Nov; 27(8):784-9. PMID: 22069260.
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    77. Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS. Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 01; 187(11):5921-30. PMID: 22043012.
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    78. Crawford F, Stadinski B, Jin N, Michels A, Nakayama M, Pratt P, Marrack P, Eisenbarth G, Kappler JW. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16729-34. PMID: 21949373.
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    79. Michels AW, Eisenbarth GS. Immune intervention in type 1 diabetes. Semin Immunol. 2011 Jun; 23(3):214-9. PMID: 21852151.
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    80. Michels AW, von Herrath M. 2011 Update: antigen-specific therapy in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2011 Aug; 18(4):235-40. PMID: 21844706.
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    81. Michels AW, Nakayama M. The anti-insulin trimolecular complex in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2010 Aug; 17(4):329-34. PMID: 20489610.
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    82. Michels A, Haugen B. Malignant struma ovarii. J Clin Endocrinol Metab. 2010 Apr; 95(4):1505. PMID: 20375218.
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    83. Michels AW, Gottlieb PA. Autoimmune polyglandular syndromes. Nat Rev Endocrinol. 2010 May; 6(5):270-7. PMID: 20309000.
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    84. Michels AW, Eisenbarth GS. Immunologic endocrine disorders. J Allergy Clin Immunol. 2010 Feb; 125(2 Suppl 2):S226-37. PMID: 20176260.
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    85. Michels AW, Eisenbarth GS. Autoimmune polyendocrine syndrome type 1 (APS-1) as a model for understanding autoimmune polyendocrine syndrome type 2 (APS-2). J Intern Med. 2009 May; 265(5):530-40. PMID: 19382992.
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    86. Bertelli JA, Ghizoni MF, Michels A. Brachial plexus dorsal rhizotomy in the treatment of upper-limb spasticity. J Neurosurg. 2000 Jul; 93(1):26-32. PMID: 10883901.
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    87. Ebtinger R, Gerber R, Michels A. [Questioning in child psychosis (author's transl)]. Ann Pediatr (Paris). 1981 Feb; 28(2):99-103. PMID: 7235540.
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