 Inducible T-Cell Co-Stimulator Protein
"Inducible T-Cell Co-Stimulator Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A costimulatory receptor that is specific for INDUCIBLE T-CELL CO-STIMULATOR LIGAND. The receptor is associated with a diverse array of immunologically-related effects including the increased synthesis of INTERLEUKIN 10 in REGULATORY T-LYMPHOCYTES and the induction of PERIPHERAL TOLERANCE.
| Descriptor ID |
D060889
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| MeSH Number(s) |
D12.776.543.750.705.222.812 D23.050.301.264.894.580 D23.101.100.894.580
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| Concept/Terms |
Inducible T-Cell Co-Stimulator Protein- Inducible T-Cell Co-Stimulator Protein
- Inducible T Cell Co Stimulator Protein
- Inducible Co-Stimulator (ICOS)
- Inducible T-Cell Co-Stimulator
- Co-Stimulator, Inducible T-Cell
- Inducible T Cell Co Stimulator
- T-Cell Co-Stimulator, Inducible
- Antigens, CD278
- CD278 Antigens
- CD278 Antigen
- Antigen, CD278
- Activation-Inducible Lymphocyte Immunomediatory Molecule
- Activation Inducible Lymphocyte Immunomediatory Molecule
- Inducible Costimulator (ICOS)
- ICOS Inducible T-Cell Co-Stimulator
- ICOS Inducible T Cell Co Stimulator
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Below are MeSH descriptors whose meaning is more general than "Inducible T-Cell Co-Stimulator Protein".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Costimulatory and Inhibitory T-Cell Receptors [D12.776.543.750.705.222]
- Inducible T-Cell Co-Stimulator Protein [D12.776.543.750.705.222.812]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
- Inducible T-Cell Co-Stimulator Protein [D23.050.301.264.894.580]
- Biomarkers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
- Inducible T-Cell Co-Stimulator Protein [D23.101.100.894.580]
Below are MeSH descriptors whose meaning is more specific than "Inducible T-Cell Co-Stimulator Protein".
This graph shows the total number of publications written about "Inducible T-Cell Co-Stimulator Protein" by people in this website by year, and whether "Inducible T-Cell Co-Stimulator Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 | | 2026 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Inducible T-Cell Co-Stimulator Protein" by people in Profiles.
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Yamada H, Yamada R, Komohara Y, Pan C, Yoshii D, Yano H, Matsubara E, Shinchi Y, Tsukamoto H, Fujiwara Y, Ikeda K, Suzuki M. Integrative analysis of T cell subset-specific ICOS expression and tumor HLA class I/II expression in lung adenocarcinoma: implications for their interaction and clinical outcome. Cancer Immunol Immunother. 2026 Feb 28; 75(3).
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Yokoi M, Murakami K, Yaguchi T, Chamoto K, Ozasa H, Yoshida H, Shirakashi M, Ito K, Komohara Y, Fujiwara Y, Yano H, Ogimoto T, Hira D, Terada T, Hirai T, Tsukamoto H. ICOS+CD4+ T cells define a high susceptibility to anti-PD-1 therapy-induced lung pathogenesis. JCI Insight. 2025 05 22; 10(10).
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Lopez-Mattei J, Yang EH, Baldassarre LA, Agha A, Blankstein R, Choi AD, Chen MY, Meyersohn N, Daly R, Slim A, Rochitte C, Blaha M, Whelton S, Dzaye O, Dent S, Milgrom S, Ky B, Iliescu C, Mamas MA, Ferencik M. Cardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS). J Cardiovasc Comput Tomogr. 2023 Jan-Feb; 17(1):66-83.
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Jha V, Nicholson LK, Gardner EM, Rahkola JT, Pratap H, Scott J, Borgeson M, Jacobelli J, Janoff EN. Impact of HIV-1 Infection and Antigen Class on T Follicular Helper Cell Responses to Pneumococcal Polysaccharide-Protein Conjugate Vaccine-13. J Immunol. 2021 05 15; 206(10):2402-2411.
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Seamans BN, Pellechio SL, Capria AL, Agyingi SE, Morenikeji OB, Ojurongbe O, Thomas BN. Genetic diversity of CD14, CD28, CTLA-4 and ICOS gene promoter polymorphism in African and American sickle cell disease. Hum Immunol. 2019 Nov; 80(11):930-936.
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Kusuda T, Uchida K, Miyoshi H, Koyabu M, Satoi S, Takaoka M, Shikata N, Uemura Y, Okazaki K. Involvement of inducible costimulator- and interleukin 10-positive regulatory T cells in the development of IgG4-related autoimmune pancreatitis. Pancreas. 2011 Oct; 40(7):1120-30.
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Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode DJ, Broadwater M, Ruff W, Flies S, Xu H, Flies D, Luo L, Wang S, Chen L. B7-h2 is a costimulatory ligand for CD28 in human. Immunity. 2011 May 27; 34(5):729-40.
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Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol. 2008 Apr 15; 180(8):5448-56.
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He J, Haskins K. Pathogenicity of T helper 2 T-cell clones from T-cell receptor transgenic non-obese diabetic mice is determined by tumour necrosis factor-alpha. Immunology. 2008 Jan; 123(1):108-17.
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Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med. 2002 Sep; 8(9):1024-32.
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