Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Kathryn M Haskins

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER

    Collapse Research 
    Collapse research activities and funding
    T32DK120520     (BENNINGER, RICHARD KP)Jul 1, 2020 - Jun 30, 2025
    NIH
    Interdisciplinary Bioengineering Research Training in Diabetes
    Role: Co-Principal Investigator
    R01DK122566     (HASKINS, KATHRYN M)Jun 15, 2019 - May 31, 2024
    NIH
    T cell repertoire for hybrid insulin peptides
    Role: Principal Investigator
    R21AI132907     (HASKINS, KATHRYN M)May 15, 2018 - Apr 30, 2021
    NIH
    Autoantibodies to hybrid insulin peptides in type 1 diabetes
    Role: Principal Investigator
    R21AR065340     (HASKINS, KATHRYN M)Apr 1, 2015 - Mar 31, 2018
    NIH
    Role of T Cells Specific for Citrullinated Fibrinogen in Rheumatoid Arthritis
    Role: Principal Investigator
    R01DK081166     (HASKINS, KATHRYN M)Apr 1, 2011 - Aug 31, 2025
    NIH
    Hybrid Peptides as Autoantigens for Diabetogenic CD4 T Cells
    Role: Principal Investigator
    R21AI065355     (HASKINS, KATHRYN M)Sep 30, 2004 - Sep 29, 2006
    NIH
    Proteomics Analysis of T Cell Autoantigens in TID2
    Role: Principal Investigator
    R01AI044482     (HASKINS, KATHRYN)Sep 30, 1998 - Aug 31, 2001
    NIH
    IMMUNOREGULATION IN THE NOD MOUSE
    Role: Principal Investigator
    R01DK050561     (HASKINS, KATHRYN M)Sep 1, 1996 - Jun 30, 2011
    NIH
    Effector Function of Autoreactive Th1 T Cells
    Role: Principal Investigator
    R56DK050561     (HASKINS, KATHRYN M)Sep 1, 1996 - Aug 31, 2006
    NIH
    Effector Function of Autoreactive Th1 T Cells
    Role: Principal Investigator
    R01DK044132     (HASKINS, KATHRYN)May 1, 1992 - Apr 30, 1999
    NIH
    ANTIGEN SPECIFICITY OF T CELL CLONES FROM THE NOD MOUSE
    Role: Principal Investigator
    T32AI007405     (TORRES, RAUL MARTIN)Sep 30, 1991 - Jul 31, 2026
    NIH
    Training Program in Immunology
    Role: Co-Principal Investigator
    R55DK044132     (HASKINS, KATHRYN)Sep 30, 1991 - Apr 30, 1992
    NIH
    ANTIGEN SPECIFICITY OF T CELL CLONES
    Role: Principal Investigator
    R23AI024530     (HASKINS, KATHRYN)Sep 1, 1986 - Aug 31, 1988
    NIH
    LIPOSOME RECONSTITUTION OF THE T CELL RECEPTOR
    Role: Principal Investigator
    R23AI022247     (HASKINS, KATHRYN)Sep 30, 1985 - Aug 31, 1986
    NIH
    LIPOSOME RECONSTITUTION OF THE T CELL RECEPTOR
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hohenstein AC, Gallegos JB, Dang M, Groegler J, Broncucia H, Tensun FA, Waugh K, Dong F, James EA, Speake C, Steck AK, Rewers MJ, Gottlieb PA, Haskins K, Delong T, Baker RL. Novel T-Cell Reactivities to Hybrid Insulin Peptides in Islet Autoantibody-Positive At-Risk Individuals. Diabetes. 2025 Jun 01; 74(6):933-942. PMID: 39820647.
      View in: PubMed
    2. Chen Y, Shen M, Gu Y, Xu X, Bian L, Yang F, Chen S, Ji L, Liu J, Zhu J, Zhang Z, Fu Q, Cai Y, Chen H, Xu K, Sun M, Zheng X, Shen J, Zhou H, Zhang M, Haskins K, Yu L, Yang T, Shi Y. Pivotal epitopes for islet antigen-specific CD8+ T cell detection improve classification of suspected type 1 diabetes with the HLA-A*0201 allele. Immunol Res. 2025 Mar 26; 73(1):65. PMID: 40133500.
      View in: PubMed
    3. Callebaut A, Guyer P, Baker RL, Gallegos JB, Hohenstein AC, Gottlieb PA, Mathieu C, Overbergh L, Haskins K, James EA. An Insulin-Chromogranin A Hybrid Peptide Activates DR11-Restricted T Cells in Human Type 1 Diabetes. Diabetes. 2024 May 01; 73(5):743-750. PMID: 38295386.
      View in: PubMed
    4. Wenzlau JM, Peterson OJ, Vomund AN, DiLisio JE, Hohenstein A, Haskins K, Wan X. Mapping of a hybrid insulin peptide in the inflamed islet ?-cells from NOD mice. Front Immunol. 2024; 15:1348131. PMID: 38455055.
      View in: PubMed
    5. Crawford SA, Groegler J, Dang M, Michel C, Powell RL, Hohenstein AC, Reyes K, Haskins K, Wiles TA, Delong T. Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate. J Biol Chem. 2023 11; 299(11):105264. PMID: 37734557.
      View in: PubMed
    6. Wenzlau JM, Gu Y, Michels A, Rewers M, Haskins K, Yu L. Identification of Autoantibodies to a Hybrid Insulin Peptide in Type 1 Diabetes. Diagnostics (Basel). 2023 Sep 04; 13(17). PMID: 37685398.
      View in: PubMed
    7. Crawford SA, Wiles TA, Wenzlau JM, Powell RL, Barbour G, Dang M, Groegler J, Barra JM, Burnette KS, Hohenstein AC, Baker RL, Tse HM, Haskins K, Delong T. Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes. Diabetes. 2022 12 01; 71(12):2793-2803. PMID: 36041196.
      View in: PubMed
    8. Wenzlau JM, DiLisio JE, Barbour G, Dang M, Hohenstein AC, Nakayama M, Delong T, Baker RL, Haskins K. Insulin B-chain hybrid peptides are agonists for T cells reactive to insulin B:9-23 in autoimmune diabetes. Front Immunol. 2022; 13:926650. PMID: 36032090.
      View in: PubMed
    9. Jamison BL, DiLisio JE, Beard KS, Neef T, Bradley B, Goodman J, Gill RG, Miller SD, Baker RL, Haskins K. Tolerogenic Delivery of a Hybrid Insulin Peptide Markedly Prolongs Islet Graft Survival in the NOD Mouse. Diabetes. 2022 03 01; 71(3):483-496. PMID: 35007324.
      View in: PubMed
    10. Neef T, Ifergan I, Beddow S, Penaloza-MacMaster P, Haskins K, Shea LD, Podojil JR, Miller SD. Tolerance Induced by Antigen-Loaded PLG Nanoparticles Affects the Phenotype and Trafficking of Transgenic CD4+ and CD8+ T Cells. Cells. 2021 12 07; 10(12). PMID: 34943952.
      View in: PubMed
    11. Srivastava N, Hu H, Vomund AN, Peterson OJ, Baker RL, Haskins K, Teyton L, Wan X, Unanue ER. Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms. Diabetes. 2021 12; 70(12):2860-2870. PMID: 34497137.
      View in: PubMed
    12. Wiles TA, Hohenstein A, Landry LG, Dang M, Powell R, Guyer P, James EA, Nakayama M, Haskins K, Delong T, Baker RL. Characterization of Human CD4 T Cells Specific for a C-Peptide/C-Peptide Hybrid Insulin Peptide. Front Immunol. 2021; 12:668680. PMID: 34113344.
      View in: PubMed
    13. DiLisio JE, Haskins K. Induction of Antigen-Specific Tolerance in Autoimmune Diabetes with Nanoparticles Containing Hybrid Insulin Peptides. Biomedicines. 2021 Feb 27; 9(3). PMID: 33673706.
      View in: PubMed
    14. Dai YD, Dias P, Margosiak A, Marquardt K, Bashratyan R, Hu WY, Haskins K, Evans LH. Endogenous retrovirus Gag antigen and its gene variants are unique autoantigens expressed in the pancreatic islets of non-obese diabetic mice. Immunol Lett. 2020 07; 223:62-70. PMID: 32335144.
      View in: PubMed
    15. Arribas-Layton D, Guyer P, Delong T, Dang M, Chow IT, Speake C, Greenbaum CJ, Kwok WW, Baker RL, Haskins K, James EA. Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01. Diabetes. 2020 07; 69(7):1492-1502. PMID: 32291282.
      View in: PubMed
    16. Haskins K, Wenzlau J. Cluster of Differentiation 4 T Cells and Neoantigens in Autoimmune Diabetes. Crit Rev Immunol. 2020; 40(5):441-446. PMID: 33463955.
      View in: PubMed
    17. Baker RL, Jamison BL, Haskins K. Hybrid insulin peptides are neo-epitopes for CD4 T cells in autoimmune diabetes. Curr Opin Endocrinol Diabetes Obes. 2019 08; 26(4):195-200. PMID: 31166225.
      View in: PubMed
    18. Baker RL, Rihanek M, Hohenstein AC, Nakayama M, Michels A, Gottlieb PA, Haskins K, Delong T. Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes. Diabetes. 2019 09; 68(9):1830-1840. PMID: 31175101.
      View in: PubMed
    19. Jamison BL, Neef T, Goodspeed A, Bradley B, Baker RL, Miller SD, Haskins K. Nanoparticles Containing an Insulin-ChgA Hybrid Peptide Protect from Transfer of Autoimmune Diabetes by Shifting the Balance between Effector T Cells and Regulatory T Cells. J Immunol. 2019 07 01; 203(1):48-57. PMID: 31109955.
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    20. Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN. Increased ?-cell proliferation before immune cell invasion prevents progression of type 1 diabetes. Nat Metab. 2019 05; 1(5):509-518. PMID: 31423480.
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    21. Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS. CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. Front Immunol. 2019; 10:99. PMID: 30766536.
      View in: PubMed
    22. Wiles TA, Powell R, Michel R, Beard KS, Hohenstein A, Bradley B, Reisdorph N, Haskins K, Delong T. Identification of Hybrid Insulin Peptides (HIPs) in Mouse and Human Islets by Mass Spectrometry. J Proteome Res. 2019 03 01; 18(3):814-825. PMID: 30585061.
      View in: PubMed
    23. Jamison BL, Haskins K. Tissue Crosstalk in T1D: Is Insulin Special? Immunity. 2018 09 18; 49(3):394-396. PMID: 30231981.
      View in: PubMed
    24. Baker RL, Jamison BL, Wiles TA, Lindsay RS, Barbour G, Bradley B, Delong T, Friedman RS, Nakayama M, Haskins K. CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse. Diabetes. 2018 09; 67(9):1836-1846. PMID: 29976617.
      View in: PubMed
    25. Babon JAB, DeNicola ME, Blodgett DM, Cr?vecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2017 08 04; 23(8):1004. PMID: 28777787.
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    26. Babon JA, DeNicola ME, Blodgett DM, Cr?vecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2017 Feb 07; 23(2):264. PMID: 28170374.
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    27. Haskins K, Buckner JH. Editorial overview: Autoimmunity. Curr Opin Immunol. 2016 12; 43:v-vii. PMID: 27839940.
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    28. Babon JA, DeNicola ME, Blodgett DM, Cr?vecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2016 12; 22(12):1482-1487. PMID: 27798614.
      View in: PubMed
    29. Wiles TA, Delong T, Baker RL, Bradley B, Barbour G, Powell RL, Reisdorph N, Haskins K. An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse. J Autoimmun. 2017 03; 78:11-18. PMID: 27802879.
      View in: PubMed
    30. Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K. Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science. 2016 Feb 12; 351(6274):711-4. PMID: 26912858.
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    31. Baker RL, Bradley B, Wiles TA, Lindsay RS, Barbour G, Delong T, Friedman RS, Haskins K. Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes. J Immunol. 2016 Jan 01; 196(1):39-43. PMID: 26608914.
      View in: PubMed
    32. Viret C, Mahiddine K, Baker RL, Haskins K, Guerder S. The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens. J Immunol. 2015 Sep 01; 195(5):1964-73. PMID: 26209627.
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    33. Lindsay RS, Corbin K, Mahne A, Levitt BE, Gebert MJ, Wigton EJ, Bradley BJ, Haskins K, Jacobelli J, Tang Q, Krummel MF, Friedman RS. Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J Immunol. 2015 Jan 15; 194(2):522-30. PMID: 25505281.
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    34. Nair KS, Abel ED, Adler SG, Dyck PJ, Gardner TW, Haskins KM, Hotamisligil G, Jensen MD, Krook A, Mandarino LJ, Mitchell BD, Pessin JE, Sowers JR, Sussel L, Wareham N, Vella A. Time to look back and to look forward. Diabetes. 2014 Apr; 63(4):1169-70. PMID: 24651796.
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    35. Gottlieb PA, Delong T, Baker RL, Fitzgerald-Miller L, Wagner R, Cook G, Rewers MR, Michels A, Haskins K. Chromogranin A is a T cell antigen in human type 1 diabetes. J Autoimmun. 2014 May; 50:38-41. PMID: 24239002.
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    36. Baker RL, Delong T, Barbour G, Bradley B, Nakayama M, Haskins K. Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice. J Immunol. 2013 Oct 15; 191(8):3990-4. PMID: 24043895.
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    37. Delong T, Baker RL, He J, Haskins K. Novel autoantigens for diabetogenic CD4 T cells in autoimmune diabetes. Immunol Res. 2013 Mar; 55(1-3):167-72. PMID: 22971988.
      View in: PubMed
    38. Cordova KN, Willis VC, Haskins K, Holers VM. A citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of rheumatoid arthritis. J Immunol. 2013 Feb 15; 190(4):1457-65. PMID: 23319740.
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    39. Delong T, Baker RL, He J, Barbour G, Bradley B, Haskins K. Diabetogenic T-cell clones recognize an altered peptide of chromogranin A. Diabetes. 2012 Dec; 61(12):3239-46. PMID: 22912420.
      View in: PubMed
    40. Baker RL, Mallevaey T, Gapin L, Haskins K. T cells interact with T cells via CD40-CD154 to promote autoimmunity in type 1 diabetes. Eur J Immunol. 2012 Mar; 42(3):672-80. PMID: 22488364.
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    41. Hume PS, He J, Haskins K, Anseth KS. Strategies to reduce dendritic cell activation through functional biomaterial design. Biomaterials. 2012 May; 33(14):3615-25. PMID: 22361099.
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    42. Nakayama M, Castoe T, Sosinowski T, He X, Johnson K, Haskins K, Vignali DA, Gapin L, Pollock D, Eisenbarth GS. Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice. Diabetes. 2012 Apr; 61(4):857-65. PMID: 22315318.
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    43. Kyewski B, Haskins K. The classical dichotomy between presentation of endogenous antigens via the MHC class I pathway and exogenous antigens via the MHC class-II pathway. Curr Opin Immunol. 2012 Feb; 24(1):67-70. PMID: 22305303.
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    44. Haskins K, Cooke A. CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes. Curr Opin Immunol. 2011 Dec; 23(6):739-45. PMID: 21917439.
      View in: PubMed
    45. Delong T, Baker RL, Reisdorph N, Reisdorph R, Powell RL, Armstrong M, Barbour G, Bradley B, Haskins K. Islet amyloid polypeptide is a target antigen for diabetogenic CD4+ T cells. Diabetes. 2011 Sep; 60(9):2325-30. PMID: 21734016.
      View in: PubMed
    46. Zimmerman MA, Haskins K, Bradley B, Gilman J, Gamboni-Robertson F, Flores SC. Autoimmune-mediated vascular injury occurs prior to sustained hyperglycemia in a murine model of type I diabetes mellitus. J Surg Res. 2011 Jun 15; 168(2):e195-202. PMID: 21470634.
      View in: PubMed
    47. Stadinski BD, Delong T, Reisdorph N, Reisdorph R, Powell RL, Armstrong M, Piganelli JD, Barbour G, Bradley B, Crawford F, Marrack P, Mahata SK, Kappler JW, Haskins K. Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol. 2010 Mar; 11(3):225-31. PMID: 20139986.
      View in: PubMed
    48. Tonkin DR, Haskins K. Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-beta-dependent manner. Eur J Immunol. 2009 May; 39(5):1313-22. PMID: 19404982.
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    49. Zhang L, Jasinski JM, Kobayashi M, Davenport B, Johnson K, Davidson H, Nakayama M, Haskins K, Eisenbarth GS. Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains. J Autoimmun. 2009 Aug; 33(1):42-9. PMID: 19286348.
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    50. Baker RL, Wagner DH, Haskins K. CD40 on NOD CD4 T cells contributes to their activation and pathogenicity. J Autoimmun. 2008 Dec; 31(4):385-92. PMID: 18951762.
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    51. Tonkin DR, He J, Barbour G, Haskins K. Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo. J Immunol. 2008 Oct 01; 181(7):4516-22. PMID: 18802054.
      View in: PubMed
    52. Burton AR, Vincent E, Arnold PY, Lennon GP, Smeltzer M, Li CS, Haskins K, Hutton J, Tisch RM, Sercarz EE, Santamaria P, Workman CJ, Vignali DA. On the pathogenicity of autoantigen-specific T-cell receptors. Diabetes. 2008 May; 57(5):1321-30. PMID: 18299317.
      View in: PubMed
    53. He J, Haskins K. Pathogenicity of T helper 2 T-cell clones from T-cell receptor transgenic non-obese diabetic mice is determined by tumour necrosis factor-alpha. Immunology. 2008 Jan; 123(1):108-17. PMID: 17983440.
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    54. Cantor J, Haskins K. Recruitment and activation of macrophages by pathogenic CD4 T cells in type 1 diabetes: evidence for involvement of CCR8 and CCL1. J Immunol. 2007 Nov 01; 179(9):5760-7. PMID: 17947648.
      View in: PubMed
    55. Nicolls MR, Haskins K, Flores SC. Oxidant stress, immune dysregulation, and vascular function in type I diabetes. Antioxid Redox Signal. 2007 Jul; 9(7):879-89. PMID: 17508913.
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    56. Weber LM, Hayda KN, Haskins K, Anseth KS. The effects of cell-matrix interactions on encapsulated beta-cell function within hydrogels functionalized with matrix-derived adhesive peptides. Biomaterials. 2007 Jul; 28(19):3004-11. PMID: 17391752.
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    57. Quinn A, McInerney M, Huffman D, McInerney B, Mayo S, Haskins K, Sercarz E. T cells to a dominant epitope of GAD65 express a public CDR3 motif. Int Immunol. 2006 Jun; 18(6):967-79. PMID: 16641112.
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    58. Kappler J, Kubo R, Haskins K, Hannum C, Marrack P, Pigeon M, McIntyre B, Allison J, Trowbridge I. The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: identification of constant and variable peptides. 1983. J Immunol. 2006 Mar 01; 176(5):2683-90. PMID: 16493022.
      View in: PubMed
    59. Weber LM, He J, Bradley B, Haskins K, Anseth KS. PEG-based hydrogels as an in vitro encapsulation platform for testing controlled beta-cell microenvironments. Acta Biomater. 2006 Jan; 2(1):1-8. PMID: 16701853.
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    60. Phillips JM, Haskins K, Cooke A. MAdCAM-1 is needed for diabetes development mediated by the T cell clone, BDC-2.5. Immunology. 2005 Dec; 116(4):525-31. PMID: 16313366.
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    61. Cantor J, Haskins K. Effector function of diabetogenic CD4 Th1 T cell clones: a central role for TNF-alpha. J Immunol. 2005 Dec 01; 175(11):7738-45. PMID: 16301684.
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    62. Ling X, Cota-Gomez A, Flores NC, Hernandez-Saavedra D, McCord JM, Marecki JC, Haskins K, McDuffie M, Powers K, Kench J, Oka M, McMurtry I, Flores SC. Alterations in redox homeostasis and prostaglandins impair endothelial-dependent vasodilation in euglycemic autoimmune nonobese diabetic mice. Free Radic Biol Med. 2005 Oct 15; 39(8):1089-98. PMID: 16198235.
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    63. Haskins K. Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse. Adv Immunol. 2005; 87:123-62. PMID: 16102573.
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    64. Pauza ME, Dobbs CM, He J, Patterson T, Wagner S, Anobile BS, Bradley BJ, Lo D, Haskins K. T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes. Diabetes. 2004 Apr; 53(4):978-88. PMID: 15047613.
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    65. Haskins K. T-cell receptor transgenic (TCR-Tg) mice from two diabetogenic CD4+ islet-antigen-specific T-cell clones. J Autoimmun. 2004 Mar; 22(2):107-9. PMID: 14987737.
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    66. Haskins K, Kench J, Powers K, Bradley B, Pugazhenthi S, Reusch J, McDuffie M. Role for oxidative stress in the regeneration of islet beta cells? J Investig Med. 2004 Jan; 52(1):45-9. PMID: 14989369.
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    67. Haskins K, Bradley B, Powers K, Fadok V, Flores S, Ling X, Pugazhenthi S, Reusch J, Kench J. Oxidative stress in type 1 diabetes. Ann N Y Acad Sci. 2003 Nov; 1005:43-54. PMID: 14679039.
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    68. Stratmann T, Martin-Orozco N, Mallet-Designe V, Poirot L, McGavern D, Losyev G, Dobbs CM, Oldstone MB, Yoshida K, Kikutani H, Mathis D, Benoist C, Haskins K, Teyton L. Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity. J Clin Invest. 2003 Sep; 112(6):902-14. PMID: 12975475.
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    69. Roberts SA, Barbour G, Matarrese MR, Mason DL, Leiter EH, Haskins K, Hanson MS. Adoptive transfer of islet antigen-autoreactive T cell clones to transgenic NOD.Ea(d)mice induces diabetes indicating a lack of I-E mediated protection against activated effector T cells. J Autoimmun. 2003 Sep; 21(2):139-47. PMID: 12935783.
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    70. Vaitaitis GM, Poulin M, Sanderson RJ, Haskins K, Wagner DH. Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the periphery. J Immunol. 2003 Apr 01; 170(7):3455-9. PMID: 12646605.
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    71. Yoshida K, Martin T, Yamamoto K, Dobbs C, M?nz C, Kamikawaji N, Nakano N, Rammensee HG, Sasazuki T, Haskins K, Kikutani H. Evidence for shared recognition of a peptide ligand by a diverse panel of non-obese diabetic mice-derived, islet-specific, diabetogenic T cell clones. Int Immunol. 2002 Dec; 14(12):1439-47. PMID: 12456592.
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    72. Wagner DH, Vaitaitis G, Sanderson R, Poulin M, Dobbs C, Haskins K. Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3782-7. PMID: 11891296.
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    73. Piganelli JD, Flores SC, Cruz C, Koepp J, Batinic-Haberle I, Crapo J, Day B, Kachadourian R, Young R, Bradley B, Haskins K. A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes. 2002 Feb; 51(2):347-55. PMID: 11812741.
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    74. Kaufman DL, Tisch R, Sarvetnick N, Chatenoud L, Harrison LC, Haskins K, Quinn A, Sercarz E, Singh B, von Herrath M, Wegmann D, Wen L, Zekzer D. Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop. Diabetes. 2001 Nov; 50(11):2459-63. PMID: 11679422.
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    75. Dobbs C, Haskins K. Comparison of a T cell clone and of T cells from a TCR transgenic mouse: TCR transgenic T cells specific for self-antigen are atypical. J Immunol. 2001 Feb 15; 166(4):2495-504. PMID: 11160310.
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    76. Haskins K, Atkinson M. Prediction of diabetes and response to therapy in individual animals: are there lessons for man? Report on the JDF/Snow Mountain Meeting, 5-7 October 2000, Winter Park, CO, USA. J Autoimmun. 2001 Feb; 16(1):15-9. PMID: 11221992.
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    77. Phillips JM, Harach SZ, Parish NM, Fehervari Z, Haskins K, Cooke A. Nondepleting anti-CD4 has an immediate action on diabetogenic effector cells, halting their destruction of pancreatic beta cells. J Immunol. 2000 Aug 15; 165(4):1949-55. PMID: 10925277.
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    78. Tree TI, O'Byrne D, Tremble JM, MacFarlane WM, Haskins K, James RF, Docherty K, Hutton JC, Banga JP. Evidence for recognition of novel islet T cell antigens by granule-specific T cell lines from new onset type 1 diabetic patients. Clin Exp Immunol. 2000 Jul; 121(1):100-5. PMID: 10886245.
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    79. Bergman B, McManaman JL, Haskins K. Biochemical characterization of a beta cell membrane fraction antigenic for autoreactive T cell clones. J Autoimmun. 2000 Jun; 14(4):343-51. PMID: 10882061.
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    80. Poulin M, Haskins K. Induction of diabetes in nonobese diabetic mice by Th2 T cell clones from a TCR transgenic mouse. J Immunol. 2000 Mar 15; 164(6):3072-8. PMID: 10706696.
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    81. Piganelli JD, Poulin M, Martin T, Allison JP, Haskins K. Cytotoxic T lymphocyte antigen 4 (CD152) regulates self-reactive T cells in BALB/c but not in the autoimmune NOD mouse. J Autoimmun. 2000 Mar; 14(2):123-31. PMID: 10677243.
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    82. Rosmalen JG, Martin T, Dobbs C, Voerman JS, Drexhage HA, Haskins K, Leenen PJ. Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes. Lab Invest. 2000 Jan; 80(1):23-30. PMID: 10652999.
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    83. Fossati G, Cooke A, Papafio RQ, Haskins K, Stockinger B. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J Exp Med. 1999 Aug 16; 190(4):577-83. PMID: 10449528.
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    84. Zaccone P, Phillips J, Conget I, Gomis R, Haskins K, Minty A, Bendtzen K, Cooke A, Nicoletti F. Interleukin-13 prevents autoimmune diabetes in NOD mice. Diabetes. 1999 Aug; 48(8):1522-8. PMID: 10426368.
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    85. Haskins K. T cell receptor gene usage in autoimmune diabetes. Int Rev Immunol. 1999; 18(1-2):61-81. PMID: 10614739.
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    86. Peterson JD, Berg R, Piganelli JD, Poulin M, Haskins K. Analysis of leukocytes recruited to the pancreas by diabetogenic T cell clones. Cell Immunol. 1998 Nov 01; 189(2):92-8. PMID: 9790722.
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    87. Piganelli JD, Martin T, Haskins K. Splenic macrophages from the NOD mouse are defective in the ability to present antigen. Diabetes. 1998 Aug; 47(8):1212-8. PMID: 9703319.
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    88. McKeever U, Khandekar S, Jesson M, Newcomb J, Gregory P, Naylor J, Haskins K, Jones B. Maternal immunization with a soluble TCR-Ig chimeric protein: long term, V beta-8 family-specific suppression of T cells by maternally transferred antibodies. J Immunol. 1997 Dec 15; 159(12):5936-45. PMID: 9550391.
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    89. Bergman B, Haskins K. Autoreactive T-cell clones from the nonobese diabetic mouse. Proc Soc Exp Biol Med. 1997 Jan; 214(1):41-8. PMID: 9012359.
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    90. McKeever U, Khandekar S, Newcomb J, Naylor J, Gregory P, Brauer P, Jesson M, Bettencourt B, Burke E, Alderson A, Banerji J, Haskins K, Jones B. Immunization with soluble BDC 2.5 T cell receptor-immunoglobulin chimeric protein:antibody specificity and protection of nonobese diabetic mice against adoptive transfer of diabetes by maternal immunization. J Exp Med. 1996 Nov 01; 184(5):1755-68. PMID: 8920864.
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    91. Haskins K, Wegmann D. Diabetogenic T-cell clones. Diabetes. 1996 Oct; 45(10):1299-305. PMID: 8826963.
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    92. Peterson JD, Haskins K. Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones. Differential requirement for CD8 T-cells. Diabetes. 1996 Mar; 45(3):328-36. PMID: 8593938.
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    93. Peterson JD, Pike B, Dallas-Pedretti A, Haskins K. Induction of diabetes with islet-specific T-cell clones is age dependent. Immunology. 1995 Jul; 85(3):455-60. PMID: 7558135.
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    94. Dallas-Pedretti A, McDuffie M, Haskins K. A diabetes-associated T-cell autoantigen maps to a telomeric locus on mouse chromosome 6. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1386-90. PMID: 7877988.
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    95. Peterson JD, Pike B, McDuffie M, Haskins K. Islet-specific T cell clones transfer diabetes to nonobese diabetic (NOD) F1 mice. J Immunol. 1994 Sep 15; 153(6):2800-6. PMID: 8077683.
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    96. Bergman B, Haskins K. Islet-specific T-cell clones from the NOD mouse respond to beta-granule antigen. Diabetes. 1994 Feb; 43(2):197-203. PMID: 8288043.
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    97. Katz JD, Wang B, Haskins K, Benoist C, Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell. 1993 Sep 24; 74(6):1089-100. PMID: 8402882.
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    98. Gill RG, Haskins K. Molecular mechanisms underlying diabetes and other autoimmune diseases. Immunol Today. 1993 Feb; 14(2):49-51. PMID: 8095390.
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    99. Bradley BJ, Haskins K, La Rosa FG, Lafferty KJ. CD8 T cells are not required for islet destruction induced by a CD4+ islet-specific T-cell clone. Diabetes. 1992 Dec; 41(12):1603-8. PMID: 1446802.
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    100. Wegmann D, Norbury-Glaser M, Bergman B, Haskins K. High efficiency presentation of TNP-conjugated islet antigen to islet-specific T cells by a hybrid B cell line expressing TNP-specific surface Ig. J Immunol. 1992 Jul 01; 149(1):77-82. PMID: 1318906.
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    101. Cand?ias S, Katz J, Benoist C, Mathis D, Haskins K. Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6167-70. PMID: 2068098.
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    102. Supon P, Stecha P, Haskins K. Anti-islet cell antibodies from NOD mice. Diabetes. 1990 Nov; 39(11):1366-72. PMID: 2227111.
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    103. Haskins K, McDuffie M. Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone. Science. 1990 Sep 21; 249(4975):1433-6. PMID: 2205920.
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    104. Bradley BJ, Wang YY, Lafferty KJ, Haskins K. In vivo activity of an islet-reactive T-cell clone. J Autoimmun. 1990 Aug; 3(4):449-56. PMID: 1977404.
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    105. Haskins K, Portas M, Bergman B, Lafferty K, Bradley B. Pancreatic islet-specific T-cell clones from nonobese diabetic mice. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):8000-4. PMID: 2510155.
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    106. B?hme J, Haskins K, Stecha P, van Ewijk W, LeMeur M, Gerlinger P, Benoist C, Mathis D. Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant. Science. 1989 Jun 09; 244(4909):1179-83. PMID: 2499048.
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    107. Haskins K, Portas M, Bradley B, Wegmann D, Lafferty K. T-lymphocyte clone specific for pancreatic islet antigen. Diabetes. 1988 Oct; 37(10):1444-8. PMID: 2458291.
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    108. Haskins K. The T-cell receptor for antigen. Year Immunol. 1985; 74-9. PMID: 3879908.
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    109. Roehm N, Herron L, Cambier J, DiGuisto D, Haskins K, Kappler J, Marrack P. The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells. Cell. 1984 Sep; 38(2):577-84. PMID: 6331891.
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    110. Haskins K, Hannum C, White J, Roehm N, Kubo R, Kappler J, Marrack P. The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype. J Exp Med. 1984 Aug 01; 160(2):452-71. PMID: 6206178.
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    111. Haskins K, Kappler J, Marrack P. The major histocompatibility complex-restricted antigen receptor on T cells. Annu Rev Immunol. 1984; 2:51-66. PMID: 6085752.
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    112. Marrack P, Shimonkevitz R, Hannum C, Haskins K, Kappler J. The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity. J Exp Med. 1983 Nov 01; 158(5):1635-46. PMID: 6195288.
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    113. Kappler J, Kubo R, Haskins K, Hannum C, Marrack P, Pigeon M, McIntyre B, Allison J, Trowbridge I. The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: identification of constant and variable peptides. Cell. 1983 Nov; 35(1):295-302. PMID: 6605199.
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    114. Kappler J, Kubo R, Haskins K, White J, Marrack P. The mouse T cell receptor: comparison of MHC-restricted receptors on two T cell hybridomas. Cell. 1983 Oct; 34(3):727-37. PMID: 6605198.
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    115. Haskins K, Kubo R, White J, Pigeon M, Kappler J, Marrack P. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J Exp Med. 1983 Apr 01; 157(4):1149-69. PMID: 6601175.
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    116. White J, Haskins KM, Marrack P, Kappler J. Use of I region-restricted, antigen-specific T cell hybridomas to produce idiotypically specific anti-receptor antibodies. J Immunol. 1983 Mar; 130(3):1033-7. PMID: 6185566.
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    117. Marrack P, Hannum C, Harris M, Haskins K, Kubo R, Pigeon M, Shimonkevitz R, White J, Kappler J. Antigen-specific, major histocompatibility complex-restricted T cell receptors. Immunol Rev. 1983; 76:131-45. PMID: 6363275.
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