 Dipeptidyl Peptidase 4
"Dipeptidyl Peptidase 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine protease that catalyses the release of an N-terminal dipeptide. Several biologically-active peptides have been identified as dipeptidyl peptidase 4 substrates including INCRETINS; NEUROPEPTIDES; and CHEMOKINES. The protein is also found bound to ADENOSINE DEAMINASE on the T-CELL surface and is believed to play a role in T-cell activation.
| Descriptor ID |
D018819
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| MeSH Number(s) |
D08.811.277.656.350.350.126 D08.811.277.656.959.250 D23.050.301.264.894.160 D23.101.100.894.160
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| Concept/Terms |
Dipeptidyl Peptidase 4- Dipeptidyl Peptidase 4
- CD26 Antigen
- Antigen, CD26
- Antigens, CD26
- Adenosine Deaminase Complexing Protein 2
- Dipeptidyl-Peptidase IV
- Dipeptidyl Peptidase IV
- CD26 Antigens
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Below are MeSH descriptors whose meaning is more general than "Dipeptidyl Peptidase 4".
Below are MeSH descriptors whose meaning is more specific than "Dipeptidyl Peptidase 4".
This graph shows the total number of publications written about "Dipeptidyl Peptidase 4" by people in this website by year, and whether "Dipeptidyl Peptidase 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 2 | 1 | 3 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dipeptidyl Peptidase 4" by people in Profiles.
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Gomaa SH, Abaza MM, Elattar HA, Amin GA, Elshahawy DM. Soluble cluster of differentiation 26/soluble dipeptidyl peptidase-4 and glypican-3 are promising serum biomarkers for the early detection of Hepatitis C virus related hepatocellular carcinoma in Egyptians. Arab J Gastroenterol. 2020 Dec; 21(4):224-232.
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Iheagwam FN, Ogunlana OO, Chinedu SN. Model Optimization and In Silico Analysis of Potential Dipeptidyl Peptidase IV Antagonists from GC-MS Identified Compounds in Nauclea latifolia Leaf Extracts. Int J Mol Sci. 2019 Nov 25; 20(23).
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Kulcsar KA, Coleman CM, Beck SE, Frieman MB. Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI Insight. 2019 10 17; 4(20).
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Hutch CR, Roelofs K, Haller A, Sorrell J, Leix K, D'Alessio DD, Augustin R, Seeley RJ, Klein T, Sandoval DA. The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice. Diabetologia. 2019 10; 62(10):1928-1937.
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Kerru N, Singh-Pillay A, Awolade P, Singh P. Current anti-diabetic agents and their molecular targets: A review. Eur J Med Chem. 2018 May 25; 152:436-488.
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Murgia A, Caboni P, Cadoni E, Serra M, Marongiu F, Laconi E. A GC-MS untargeted metabolomics analysis in the plasma and liver of rats lacking dipeptidyl-peptidase type IV enzyme activity. J Physiol Biochem. 2017 Nov; 73(4):575-582.
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Mah W, Jiang G, Olver D, Gallant-Behm C, Wiebe C, Hart DA, Koivisto L, Larjava H, H?kkinen L. Elevated CD26 Expression by Skin Fibroblasts Distinguishes a Profibrotic Phenotype Involved in Scar Formation Compared to Gingival Fibroblasts. Am J Pathol. 2017 Aug; 187(8):1717-1735.
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Coleman CM, Sisk JM, Halasz G, Zhong J, Beck SE, Matthews KL, Venkataraman T, Rajagopalan S, Kyratsous CA, Frieman MB. CD8+ T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome. J Virol. 2017 Jan 01; 91(1).
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Qin L, Chong T, Rodriguez R, Pugazhenthi S. Glucagon-Like Peptide-1-Mediated Modulation of Inflammatory Pathways in the Diabetic Brain: Relevance to Alzheimer's Disease. Curr Alzheimer Res. 2016; 13(12):1346-1355.
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Serra MP, Marongiu F, Marongiu M, Contini A, Laconi E. Cell-autonomous decrease in proliferative competitiveness of the aged hepatocyte. J Hepatol. 2015 Jun; 62(6):1341-8.
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