 HMG-Box Domains
"HMG-Box Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB PROTEINS, a number of sequence specific TRANSCRIPTION FACTORS, and other DNA-BINDING PROTEINS. The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. The domain has the capacity to recognize and/or induce specific DNA structures and effect the accessibility of the DNA to other proteins involved in transcription, recombination, or DNA repair. (Note that not all HIGH MOBILITY GROUP PROTEINS contain this domain.)
| Descriptor ID |
D024742
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| MeSH Number(s) |
G02.111.570.820.709.275.750.235
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| Concept/Terms |
HMG-Box Domains- HMG-Box Domains
- Domain, HMG-Box
- Domains, HMG-Box
- HMG Box Domains
- High Mobility Group-Box Domains
- High Mobility Group Box Domains
- HMG-Box Domain
- HMG Box Domain
- HMG-1-Box Domain
- Domain, HMG-1-Box
- Domains, HMG-1-Box
- HMG 1 Box Domain
- HMG-1-Box Domains
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Below are MeSH descriptors whose meaning is more general than "HMG-Box Domains".
Below are MeSH descriptors whose meaning is more specific than "HMG-Box Domains".
This graph shows the total number of publications written about "HMG-Box Domains" by people in this website by year, and whether "HMG-Box Domains" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "HMG-Box Domains" by people in Profiles.
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S?nchez-Giraldo R, Acosta-Reyes FJ, Malarkey CS, Saperas N, Churchill ME, Campos JL. Two high-mobility group box domains act together to underwind and kink DNA. Acta Crystallogr D Biol Crystallogr. 2015 Jul; 71(Pt 7):1423-32.
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Gangelhoff TA, Mungalachetty PS, Nix JC, Churchill ME. Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A. Nucleic Acids Res. 2009 Jun; 37(10):3153-64.
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Dragan AI, Read CM, Makeyeva EN, Milgotina EI, Churchill ME, Crane-Robinson C, Privalov PL. DNA binding and bending by HMG boxes: energetic determinants of specificity. J Mol Biol. 2004 Oct 15; 343(2):371-93.
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