 Multiple Sclerosis
"Multiple Sclerosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Descriptor ID |
D009103
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| MeSH Number(s) |
C10.114.375.500 C10.314.350.500 C20.111.258.250.500
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| Concept/Terms |
Multiple Sclerosis- Multiple Sclerosis
- Sclerosis, Multiple
- Sclerosis, Disseminated
- Disseminated Sclerosis
- MS (Multiple Sclerosis)
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Below are MeSH descriptors whose meaning is more general than "Multiple Sclerosis".
Below are MeSH descriptors whose meaning is more specific than "Multiple Sclerosis".
This graph shows the total number of publications written about "Multiple Sclerosis" by people in this website by year, and whether "Multiple Sclerosis" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 2 | 0 | 2 | | 1998 | 1 | 0 | 1 | | 2000 | 2 | 0 | 2 | | 2001 | 3 | 0 | 3 | | 2002 | 1 | 1 | 2 | | 2003 | 6 | 0 | 6 | | 2004 | 2 | 1 | 3 | | 2005 | 8 | 0 | 8 | | 2006 | 7 | 1 | 8 | | 2007 | 7 | 1 | 8 | | 2008 | 6 | 1 | 7 | | 2009 | 8 | 0 | 8 | | 2010 | 8 | 0 | 8 | | 2011 | 8 | 2 | 10 | | 2012 | 6 | 2 | 8 | | 2013 | 5 | 3 | 8 | | 2014 | 9 | 1 | 10 | | 2015 | 8 | 0 | 8 | | 2016 | 10 | 3 | 13 | | 2017 | 23 | 3 | 26 | | 2018 | 18 | 0 | 18 | | 2019 | 18 | 2 | 20 | | 2020 | 18 | 2 | 20 | | 2021 | 19 | 2 | 21 | | 2022 | 24 | 1 | 25 | | 2023 | 38 | 0 | 38 | | 2024 | 24 | 2 | 26 | | 2025 | 18 | 1 | 19 | | 2026 | 4 | 1 | 5 |
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Below are the most recent publications written about "Multiple Sclerosis" by people in Profiles.
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Apeltsin L, Asokan S, Freitas B, Karekar K, Guzman S, Alvarez E, Yu X. Multiplex Detection of Immunoglobulins Uncovers Intrathecal IgA Elevation in Multiple Sclerosis. Cells. 2026 May 10; 15(10).
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Morcom L, Xia W, Xu Z, Awasthi Y, Geywitz C, Ellis MO, Noli T, Zulji A, Yamamoto D, Girdler GC, Kai L, Zhu K, Wei M, Tang XY, Hoi KK, Gonzalez-Maya J, Duncan GJ, Vaquie AM, Gold Diaz D, Kawaguchi R, Liu E, Sun Y, Yang D, Jordan GD, Lu IL, Holmqvist S, Bartels T, Ridley K, Choi JJ, Franco SJ, Huang EJ, Emery B, Geschwind D, Schirmer L, Balmus G, Popko B, Fancy SPJ, Rowitch DH. DNA damage burden causes selective CUX2 neuron loss in neuroinflammation. Nature. 2026 May; 653(8115):809-818.
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Asokan S, Zhou W, Fringuello A, Pointon T, Kennedy A, Freitas B, Tumas French J, Zhao H, Coughlan C, Alvarez E, Yu X. CNS-compartmentalized IgG aggregates and glycosylation in multiple sclerosis contribute to oligoclonal bands and neuronal cytotoxicity. Front Immunol. 2026; 17:1689835.
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Jacques K, Race J, Goyne C, Fair A, Schuette A, Yang JH, Caillier S, Aaen GS, Abrams A, Benson L, Casper TC, Chitnis T, Gorman MP, Lotze T, Krupp L, Mar S, Ness J, Rensel M, Rodriguez M, Rose J, Schreiner T, Tillema JM, Waldman A, Wheeler Y, Oksenberg J, Lin J, Waubant E, Graves JS. Telomere length as a marker of biological age in paediatric multiple sclerosis. J Neurol Neurosurg Psychiatry. 2026 Mar 13; 97(4):302-308.
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Henry M, Crompton T, Alvarez E, Enoka RM. Impaired force control and muscle activation during isometric contractions in people with multiple sclerosis. J Electromyogr Kinesiol. 2026 Apr; 87:103124.
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Marrie RA, Dobson R, Baranzini SE, Salvetti M, Bailey C, Bebo B, Davis B, Greenland R, Lyden J, Mckay F, Morahan J, Petrin J, Valentine P, Taylor B. Toward a global research agenda for preventing multiple sclerosis. Mult Scler. 2026 Feb; 32(2):151-162.
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Sherman SR, Lima NS, Motl RW, Reder AT, Baynard T, Fernhall B, Hibner BA. Impaired inactive limb blood flow regulation in adults with multiple sclerosis during sympathoexcitatory stimuli. Physiol Rep. 2025 Dec; 13(23):e70694.
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Abrams AW, Waltz M, Casper TC, Aaen G, Benson LA, Bernfeld EM, Charvet LE, Chitnis T, Francisco C, Gorman MP, Graves JS, Krupp L, O'Neill K, Lotze TE, Mar S, Ness J, Rensel M, Rodriguez M, Rose J, Rutatangwa A, Schreiner T, Shukla N, Tillema JM, Weinstock-Guttman B, Wheeler Y, Waubant E, Krysko KM. Real-World Effectiveness of Switching to Oral or Infusion Versus Injectable Disease-Modifying Therapy in Pediatric Multiple Sclerosis. Ann Neurol. 2026 03; 99(3):715-729.
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Yang JH, Race J, Sumowski P, Jacques K, Fardad S, Fair A, Hazlett A, Lin J, Yilmaz D, Aaen G, Abrams A, Benson L, Casper TC, Chitnis T, Gorman M, Lotze T, Krupp L, Mar S, Ness J, Rensel M, Rose J, Schreiner T, Tillema JM, Waldman A, Wheeler Y, Barcellos LF, Waubant E, Graves JS. Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis. Mult Scler. 2025 Dec; 31(14):1641-1650.
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Kammeyer R, Sillau S, Chapman K, Lindwall JJ, Hutaff-Lee C, Schreiner T. Self-reported quality of life related to cognitive function and fatigue in adults with multiple sclerosis. Mult Scler Relat Disord. 2025 Dec; 104:106809.
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