 Multiple Sclerosis
"Multiple Sclerosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Descriptor ID |
D009103
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| MeSH Number(s) |
C10.114.375.500 C10.314.350.500 C20.111.258.250.500
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| Concept/Terms |
Multiple Sclerosis- Multiple Sclerosis
- Sclerosis, Multiple
- Sclerosis, Disseminated
- Disseminated Sclerosis
- MS (Multiple Sclerosis)
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Below are MeSH descriptors whose meaning is more general than "Multiple Sclerosis".
Below are MeSH descriptors whose meaning is more specific than "Multiple Sclerosis".
This graph shows the total number of publications written about "Multiple Sclerosis" by people in this website by year, and whether "Multiple Sclerosis" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 2 | 0 | 2 | | 1998 | 1 | 0 | 1 | | 2000 | 2 | 0 | 2 | | 2001 | 3 | 0 | 3 | | 2002 | 1 | 1 | 2 | | 2003 | 6 | 0 | 6 | | 2004 | 2 | 1 | 3 | | 2005 | 9 | 0 | 9 | | 2006 | 7 | 1 | 8 | | 2007 | 7 | 1 | 8 | | 2008 | 6 | 1 | 7 | | 2009 | 8 | 0 | 8 | | 2010 | 8 | 0 | 8 | | 2011 | 8 | 2 | 10 | | 2012 | 6 | 2 | 8 | | 2013 | 5 | 3 | 8 | | 2014 | 9 | 1 | 10 | | 2015 | 8 | 0 | 8 | | 2016 | 10 | 4 | 14 | | 2017 | 23 | 2 | 25 | | 2018 | 18 | 0 | 18 | | 2019 | 17 | 1 | 18 | | 2020 | 18 | 2 | 20 | | 2021 | 18 | 2 | 20 | | 2022 | 24 | 1 | 25 | | 2023 | 38 | 0 | 38 | | 2024 | 23 | 2 | 25 | | 2025 | 18 | 1 | 19 | | 2026 | 7 | 2 | 9 |
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Below are the most recent publications written about "Multiple Sclerosis" by people in Profiles.
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Scharf A, Cohen JA, Marrie RA, Miller AE, Waubant E, Kilbane M, Luskin E, Azevedo CJ, Dever M, Alvarez E, Calabresi PA, Chahin S, Freeman L, Nakamura K, Longbrake EE, Mowry EM, Oh J, Rodrigues PR, Ramos M, Sotirchos ES, Cutter GR, Kaisey M, Amin M, Toljan K, Illenberger N, Bilello M, Lee J, Maya M, Obusez EC, Schindler MK, Suthiphosuwan S, Ulano A, Shinohara RT, Reich DS, Solomon AJ, Sicotte NL, Sati P, Ontaneda D. Application of the 2024 McDonald Criteria in Individuals With Nonspecific Symptoms or Incidental Imaging Findings in a Multicenter Study. Neurology. 2026 Jul 14; 107(1):e218183.
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Tallantyre EC, Planchon SM, Howard H, Mays J, Frowd N, Cohen JA, Coles A, Hersh CM, Miller DM, Dever M, Gray EH, LaRocca NG, Nakamura K, Bale C, Covey-Crump G, Alvarez E, Arun T, Brownlee WJ, Craner M, Freeman L, Frost N, Goldman MD, Gupta RK, Harding KE, Hobart J, Hutton GJ, Hyland MH, Kalra S, Kannan M, Kantarci O, Lashley D, Lily O, Mahad D, Nicholas JA, Nicholas R, Paling D, Pearson OR, Rice CM, Samudralwar R, Schmalstieg WF, Singh M, Zune The E, Weinstock-Guttman B, Zabeti A, Love TE, Gunzler DD, Liu Y, Gerry S, Evangelou N, Ontaneda D. Disease-modifying treatment preferences and decision-making in a multiple sclerosis randomized and observational clinical trial (DELIVER-MS). Mult Scler. 2026 Jun; 32(7):722-736.
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Apeltsin L, Asokan S, Freitas B, Karekar K, Guzman S, Alvarez E, Yu X. Multiplex Detection of Immunoglobulins Uncovers Intrathecal IgA Elevation in Multiple Sclerosis. Cells. 2026 May 10; 15(10).
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Hamdy E, Talaat F, Ramadan I, Oertel FC, Bennett JL, Abousteit A, Almashad SS, Zeineddine M, Hassan A, Said SM, Carnero Contentti E, Gaber D, Zakaria M, Ahmed S, Grigoriadis N, Fouda BH, Shalaby NM, Nasr N, Paul F, Zamzam D, Krupp L, Sayed A, Hassan SS, Naseer MA, Hegazy MI, Galeel AA, Elmesnshawy I, Salama S. Development and expert refinement of a stratified framework for progression independent of relapse activity (PIRA) in multiple sclerosis. Clin Neurol Neurosurg. 2026 Aug; 267:109430.
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Vasilenko N, Ruschil C, Stadelmaier J, Tieck MP, Schembecker S, Owens GP, Bennett JL, Berthele A, Ziemann U, Poli S, Snaidero N, Nahnsen S, Jarboui MA, Bichmann L, Gabernet G, Kowarik MC. Extensive peripheral immunoglobulin repertoire analyses in people with multiple sclerosis reveal disease-specific signatures and distinct treatment effects of disease modifying drugs. J Neuroinflammation. 2026 Apr 14; 23(1).
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Morcom L, Xia W, Xu Z, Awasthi Y, Geywitz C, Ellis MO, Noli T, Zulji A, Yamamoto D, Girdler GC, Kai L, Zhu K, Wei M, Tang XY, Hoi KK, Gonzalez-Maya J, Duncan GJ, Vaquie AM, Gold Diaz D, Kawaguchi R, Liu E, Sun Y, Yang D, Jordan GD, Lu IL, Holmqvist S, Bartels T, Ridley K, Choi JJ, Franco SJ, Huang EJ, Emery B, Geschwind D, Schirmer L, Balmus G, Popko B, Fancy SPJ, Rowitch DH. DNA damage burden causes selective CUX2 neuron loss in neuroinflammation. Nature. 2026 May; 653(8115):809-818.
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Asokan S, Zhou W, Fringuello A, Pointon T, Kennedy A, Freitas B, Tumas French J, Zhao H, Coughlan C, Alvarez E, Yu X. CNS-compartmentalized IgG aggregates and glycosylation in multiple sclerosis contribute to oligoclonal bands and neuronal cytotoxicity. Front Immunol. 2026; 17:1689835.
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Jacques K, Race J, Goyne C, Fair A, Schuette A, Yang JH, Caillier S, Aaen GS, Abrams A, Benson L, Casper TC, Chitnis T, Gorman MP, Lotze T, Krupp L, Mar S, Ness J, Rensel M, Rodriguez M, Rose J, Schreiner T, Tillema JM, Waldman A, Wheeler Y, Oksenberg J, Lin J, Waubant E, Graves JS. Telomere length as a marker of biological age in paediatric multiple sclerosis. J Neurol Neurosurg Psychiatry. 2026 Mar 13; 97(4):302-308.
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Henry M, Crompton T, Alvarez E, Enoka RM. Impaired force control and muscle activation during isometric contractions in people with multiple sclerosis. J Electromyogr Kinesiol. 2026 Apr; 87:103124.
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Marrie RA, Dobson R, Baranzini SE, Salvetti M, Bailey C, Bebo B, Davis B, Greenland R, Lyden J, Mckay F, Morahan J, Petrin J, Valentine P, Taylor B. Toward a global research agenda for preventing multiple sclerosis. Mult Scler. 2026 Feb; 32(2):151-162.
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