 Polymyxins
"Polymyxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Basic lipopeptide antibiotic group obtained from Bacillus polymyxa. They affect the cell membrane by detergent action and may cause neuromuscular and kidney damage. At least eleven different members of the polymyxin group have been identified, each designated by a letter.
| Descriptor ID |
D011113
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| MeSH Number(s) |
D04.345.566.780 D10.477.750 D12.644.050.600 D12.644.641.780 D12.776.543.695.054.600
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polymyxins".
Below are MeSH descriptors whose meaning is more specific than "Polymyxins".
This graph shows the total number of publications written about "Polymyxins" by people in this website by year, and whether "Polymyxins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 | | 2005 | 2 | 0 | 2 | | 2014 | 1 | 0 | 1 | | 2023 | 2 | 0 | 2 |
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Below are the most recent publications written about "Polymyxins" by people in Profiles.
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Mu?oz-Escudero D, Breazeale SD, Lee M, Guan Z, Raetz CRH, Sousa MC. Structure and Function of ArnD. A Deformylase Essential for Lipid A Modification with 4-Amino-4-deoxy-l-arabinose and Polymyxin Resistance. Biochemistry. 2023 10 17; 62(20):2970-2981.
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Mitchell ME, Gatzeva-Topalova PZ, Bargmann AD, Sammakia T, Sousa MC. Targeting the Conformational Change in ArnA Dehydrogenase for Selective Inhibition of Polymyxin Resistance. Biochemistry. 2023 07 18; 62(14):2216-2227.
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Lee M, Sousa MC. Structural basis for substrate specificity in ArnB. A key enzyme in the polymyxin resistance pathway of Gram-negative bacteria. Biochemistry. 2014 Feb 04; 53(4):796-805.
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Gatzeva-Topalova PZ, May AP, Sousa MC. Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance. Structure. 2005 Jun; 13(6):929-42.
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Gatzeva-Topalova PZ, May AP, Sousa MC. Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. Biochemistry. 2005 Apr 12; 44(14):5328-38.
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Gatzeva-Topalova PZ, May AP, Sousa MC. Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. Biochemistry. 2004 Oct 26; 43(42):13370-9.
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Pugazhenthi S, Mantha SV, Khandelwal RL. Inhibitory effect of H-7, H-8 and polymyxin B on liver protein kinase C-induced phosphorylation of endogenous substrates. Biochem Int. 1990; 20(5):941-8.
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Flynn PM, Shenep JL, Stokes DC, Fairclough D, Hildner WK. Polymyxin B moderates acidosis and hypotension in established, experimental gram-negative septicemia. J Infect Dis. 1987 Nov; 156(5):706-12.
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Morrison DC, Roser JF, Cochrane CG, Henson PM. The initiation of mast cell degranulation: activation at the cell membrane. J Immunol. 1975 Mar; 114(3):966-70.
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Morrison DC, Roser JF, Henson PM, Cochrane CG. Activation of rat mast cells by low molecular weight stimuli. J Immunol. 1974 Feb; 112(2):573-82.
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