 Dactinomycin
"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
| Descriptor ID |
D003609
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| MeSH Number(s) |
D03.633.300.200 D04.345.566.252 D12.644.641.252
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| Concept/Terms |
Cosmegen- Cosmegen
- Cosmegen Lyovac
- Lyovac, Cosmegen
- Lyovac-Cosmegen
- Lyovac Cosmegen
- LyovacCosmegen
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Below are MeSH descriptors whose meaning is more general than "Dactinomycin".
Below are MeSH descriptors whose meaning is more specific than "Dactinomycin".
This graph shows the total number of publications written about "Dactinomycin" by people in this website by year, and whether "Dactinomycin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2001 | 0 | 2 | 2 | | 2002 | 1 | 0 | 1 | | 2005 | 1 | 1 | 2 | | 2012 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dactinomycin" by people in Profiles.
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Child JR, Chen Q, Reid DW, Jagannathan S, Nicchitta CV. Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. RNA. 2021 10; 27(10):1241-1256.
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Barutcu AR, Blencowe BJ, Rinn JL. Differential contribution of steady-state RNA and active transcription in chromatin organization. EMBO Rep. 2019 10 04; 20(10):e48068.
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Onyiah JC, Schaefer REM, Colgan SP. A Central Role for Heme Oxygenase-1 in the Control of Intestinal Epithelial Chemokine Expression. J Innate Immun. 2018; 10(3):228-238.
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Lu S, Natarajan SK, Mott JL, Kharbanda KK, Harrison-Findik DD. Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway. PLoS One. 2016; 11(1):e0147474.
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Goulart-Silva F, Serrano-Nascimento C, Texeira SS, Nunes MT. Triiodothyronine (T3) induces proinsulin gene expression by activating PI3K: possible roles for GSK-3? and the transcriptional factor PDX-1. Exp Clin Endocrinol Diabetes. 2013 Jan; 121(1):14-9.
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Golkar L, Ding XZ, Ujiki MB, Salabat MR, Kelly DL, Scholtens D, Fought AJ, Bentrem DJ, Talamonti MS, Bell RH, Adrian TE. Resveratrol inhibits pancreatic cancer cell proliferation through transcriptional induction of macrophage inhibitory cytokine-1. J Surg Res. 2007 Apr; 138(2):163-9.
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Benoit MR, Li W, Stodieck LS, Lam KS, Winther CL, Roane TM, Klaus DM. Microbial antibiotic production aboard the International Space Station. Appl Microbiol Biotechnol. 2006 Apr; 70(4):403-11.
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Barnhart BC, Pietras EM, Algeciras-Schimnich A, Salmena L, Sayama K, Hakem R, Peter ME. CD95 apoptosis resistance in certain cells can be overcome by noncanonical activation of caspase-8. Cell Death Differ. 2005 Jan; 12(1):25-37.
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Lam KS, Gustavson DR, Pirnik DL, Pack E, Bulanhagui C, Mamber SW, Forenza S, Stodieck LS, Klaus DM. The effect of space flight on the production of actinomycin D by Streptomyces plicatus. J Ind Microbiol Biotechnol. 2002 Dec; 29(6):299-302.
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Verneris M, McDougall IR, Becton D, Link MP. Thyroid carcinoma after successful treatment of osteosarcoma: a report of three patients. J Pediatr Hematol Oncol. 2001 Jun-Jul; 23(5):312-5.
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