 Defensins
"Defensins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Family of antimicrobial peptides that have been identified in humans, animals, and plants. They are thought to play a role in host defenses against infections, inflammation, wound repair, and acquired immunity.
| Descriptor ID |
D023082
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| MeSH Number(s) |
D12.644.050.200 D12.776.543.695.054.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Defensins".
Below are MeSH descriptors whose meaning is more specific than "Defensins".
This graph shows the total number of publications written about "Defensins" by people in this website by year, and whether "Defensins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Defensins" by people in Profiles.
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Simon A, Kullberg BJ, Tripet B, Boerman OC, Zeeuwen P, van der Ven-Jongekrijg J, Verweij P, Schalkwijk J, Hodges R, van der Meer JW, Netea MG. Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity. Antimicrob Agents Chemother. 2008 Apr; 52(4):1407-12.
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Suzuki T, Chow CW, Downey GP. Role of innate immune cells and their products in lung immunopathology. Int J Biochem Cell Biol. 2008; 40(6-7):1348-61.
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Moraes TJ, Zurawska JH, Downey GP. Neutrophil granule contents in the pathogenesis of lung injury. Curr Opin Hematol. 2006 Jan; 13(1):21-7.
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Singh PK, Jia HP, Wiles K, Hesselberth J, Liu L, Conway BA, Greenberg EP, Valore EV, Welsh MJ, Ganz T, Tack BF, McCray PB. Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14961-6.
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Zimmermann GR, Legault P, Selsted ME, Pardi A. Solution structure of bovine neutrophil beta-defensin-12: the peptide fold of the beta-defensins is identical to that of the classical defensins. Biochemistry. 1995 Oct 17; 34(41):13663-71.
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Casteels-Josson K, Zhang W, Capaci T, Casteels P, Tempst P. Acute transcriptional response of the honeybee peptide-antibiotics gene repertoire and required post-translational conversion of the precursor structures. J Biol Chem. 1994 Nov 18; 269(46):28569-75.
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Skalicky JJ, Selsted ME, Pardi A. Structure and dynamics of the neutrophil defensins NP-2, NP-5, and HNP-1: NMR studies of amide hydrogen exchange kinetics. Proteins. 1994 Sep; 20(1):52-67.
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Pardi A, Zhang XL, Selsted ME, Skalicky JJ, Yip PF. NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1. Biochemistry. 1992 Nov 24; 31(46):11357-64.
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Zhang XL, Selsted ME, Pardi A. NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1. Biochemistry. 1992 Nov 24; 31(46):11348-56.
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Kominos D, Bassolino DA, Levy RM, Pardi A. Analysis of side-chain conformational distributions in neutrophil peptide-5 NMR structures. Biopolymers. 1990 Dec; 29(14):1807-22.
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