 Cyclosporins
"Cyclosporins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
| Descriptor ID |
D003524
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| MeSH Number(s) |
D04.345.566.235 D12.644.641.235
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cyclosporins".
Below are MeSH descriptors whose meaning is more specific than "Cyclosporins".
This graph shows the total number of publications written about "Cyclosporins" by people in this website by year, and whether "Cyclosporins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cyclosporins" by people in Profiles.
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Liu Y, Lillehei K, Cobb WN, Christians U, Ng KY. Overcoming MDR by ultrasound-induced hyperthermia and P-glycoprotein modulation. Biochem Biophys Res Commun. 2001 Nov 23; 289(1):62-8.
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Cho CW, Liu Y, Yan X, Henthorn T, Ng KY. Carrier-mediated uptake of rhodamine 123: implications on its use for MDR research. Biochem Biophys Res Commun. 2000 Dec 09; 279(1):124-30.
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Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb; 27(2):173-9.
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Christians U, Kohlhaw K, S?rig T, Bader A, Schottmann R, Linck A, Ringe B, Sewing KF. Parallel blood concentrations of second-generation cyclosporine metabolites and bilirubin in liver graft recipients. Ther Drug Monit. 1995 Oct; 17(5):487-98.
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Radeke HH, Christians U, Sewing KF, Resch K. The synergistic immunosuppressive potential of cyclosporin metabolite combinations. Int J Immunopharmacol. 1992 May; 14(4):595-604.
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Nussenblatt RB, Palestine AG, Chan CC, Stevens G, Mellow SD, Green SB. Randomized, double-masked study of cyclosporine compared to prednisolone in the treatment of endogenous uveitis. Am J Ophthalmol. 1991 Aug 15; 112(2):138-46.
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Chan CC, Palestine AG, Davis JL, de Smet MD, McLean IW, Burnier M, Drouilhet JH, Nussenblatt RB. Role of chorioretinal biopsy in inflammatory eye disease. Ophthalmology. 1991 Aug; 98(8):1281-6.
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Sokol RJ, Johnson KE, Karrer FM, Narkewicz MR, Smith D, Kam I. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet. 1991 Jul 27; 338(8761):212-4.
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Radeke HH, Christians U, Bleck JS, Sewing KF, Resch K. Additive and synergistic effects of cyclosporine metabolites on glomerular mesangial cells. Kidney Int. 1991 Jun; 39(6):1255-66.
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Christians U, Radeke HH, Kownatzki R, Schiebel HM, Schottmann R, Sewing KF. Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations. Clin Biochem. 1991 Jun; 24(3):271-5.
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