 Xiang Wang
| Title | Associate Professor |
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| Institution | University of Colorado Boulder |
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| Department | Chemistry |
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| Phone | 303/492-6266 |
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 Research R41CA291231 (FORD, HEIDE L.)Aug 15, 2024 - Jul 31, 2025 NIH
Preclinical Studies to Develop an Eya2 Tyr Phosphatase Inhibitor as a Novel Medulloblastoma Therapeutic
Role: Co-Principal Investigator |
| R33AI121365 (DETWEILER, CORRELLA)Dec 1, 2015 - Nov 30, 2021 NIH
A Novel Screen for Antibacterials that Are Non-Toxic to Mammals
Role: Co-Principal Investigator |
| R33AI121581 (WANG, XIANG)Dec 1, 2015 - Nov 30, 2021 NIH
Development of Novel Resistance-Modifying Agents for MRSA
Role: Principal Investigator |
| R21AI121365 (DETWEILER, CORRELLA)Dec 1, 2015 - Nov 30, 2017 NIH
A Novel Screen for Antibacterials that Are Non-Toxic to Mammals
Role: Co-Principal Investigator |
| R21AI121581 (WANG, XIANG)Dec 1, 2015 - Nov 30, 2017 NIH
Development of Novel Resistance-Modifying Agents for MRSA
Role: Principal Investigator |
| R01GM098390 (WANG, XIANG)Aug 1, 2012 - Jul 31, 2018 NIH
Specific Chemical Probes for Histone Demethylases
Role: Principal Investigator |
Bibliographic
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Harris SL, Dutta S, Liu N, Wollenberg T, Wang X. Extended structure-activity relationship studies of the [1,2,5]oxadiazolo[3,4-b]pyrazine-containing colistin adjuvants. Bioorg Med Chem Lett. 2025 Jan 01; 115:130008. PMID: 39481690.
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Dutta S, Eyolfson S, Zhu Y, Gao Y, Wang X. Practical synthesis of isoindolines yields potent colistin potentiators for multidrug-resistant Acinetobacter baumannii. Org Biomol Chem. 2024 05 22; 22(20):4057-4061. PMID: 38716633.
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Dutta S, Liu N, Gao Y, Beck L, Wang X. Structure-activity relationship studies of [1,2,5]oxadiazolo[3,4-b]pyrazine-containing polymyxin-selective resistance-modifying agents. Bioorg Med Chem Lett. 2022 09 15; 72:128878. PMID: 35788034.
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Wang X, Chen J, Wang W, Jaunarajs A, Wang X. Tryptoline-based benzothiazoles re-sensitize MRSA to ß-lactam antibiotics. Bioorg Med Chem. 2019 11 01; 27(21):115095. PMID: 31521461.
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He W, Griffiths BM, Wang W, Wang X. Diastereoselective synthesis and biological evaluation of enantiomerically pure tricyclic indolines. Org Biomol Chem. 2017 May 16; 15(19):4241-4245. PMID: 28466945.
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Zhu Y, Cleaver L, Wang W, Podoll JD, Walls S, Jolly A, Wang X. Tetracyclic indolines as a novel class of ß-lactam-selective resistance-modifying agent for MRSA. Eur J Med Chem. 2017 Jan 05; 125:130-142. PMID: 27657810.
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Xu W, Wang W, Wang X. Gold-Catalyzed Cyclization Leads to a Bridged Tetracyclic Indolenine that Represses ß-Lactam Resistance. Angew Chem Int Ed Engl. 2015 Aug 10; 54(33):9546-9. PMID: 26074499.
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Wang W, Marholz LJ, Wang X. Novel Scaffolds of Cell-Active Histone Demethylase Inhibitors Identified from High-Throughput Screening. J Biomol Screen. 2015 Jul; 20(6):821-7. PMID: 25883088.
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Michael Barbour P, Podoll JD, Marholz LJ, Wang X. Discovery and initial structure-activity relationships of N-benzyl tricyclic indolines as antibacterials for methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett. 2014 Dec 15; 24(24):5602-5605. PMID: 25466183.
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Wang XA, Cianci CW, Yu KL, Combrink KD, Thuring JW, Zhang Y, Civiello RL, Kadow KF, Roach J, Li Z, Langley DR, Krystal M, Meanwell NA. Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity. Bioorg Med Chem Lett. 2007 Aug 15; 17(16):4592-8. PMID: 17576060.
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Yu KL, Wang XA, Civiello RL, Trehan AK, Pearce BC, Yin Z, Combrink KD, Gulgeze HB, Zhang Y, Kadow KF, Cianci CW, Clarke J, Genovesi EV, Medina I, Lamb L, Wyde PR, Krystal M, Meanwell NA. Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo. Bioorg Med Chem Lett. 2006 Mar 01; 16(5):1115-22. PMID: 16368233.
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Yu KL, Zhang Y, Civiello RL, Trehan AK, Pearce BC, Yin Z, Combrink KD, Gulgeze HB, Wang XA, Kadow KF, Cianci CW, Krystal M, Meanwell NA. Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives. Bioorg Med Chem Lett. 2004 Mar 08; 14(5):1133-7. PMID: 14980651.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2004 | 1 | | 2005 | 1 | | 2007 | 1 | | 2014 | 1 | | 2015 | 2 | | 2016 | 1 | | 2017 | 1 | | 2019 | 1 | | 2022 | 1 | | 2024 | 2 |
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