 NADPH Oxidases
"NADPH Oxidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
| Descriptor ID |
D019255
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| MeSH Number(s) |
D08.811.682.608.575 D12.776.331.894 D12.776.543.653
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| Concept/Terms |
NADPH Oxidases- NADPH Oxidases
- Oxidases, NADPH
- NAD(P)H oxidase
- NADPH Oxidase
- Oxidase, NADPH
- Nox Proteins
- NAD(P)H Oxidases
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Below are MeSH descriptors whose meaning is more general than "NADPH Oxidases".
Below are MeSH descriptors whose meaning is more specific than "NADPH Oxidases".
This graph shows the total number of publications written about "NADPH Oxidases" by people in this website by year, and whether "NADPH Oxidases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 2 | 0 | 2 | | 2001 | 2 | 0 | 2 | | 2002 | 0 | 3 | 3 | | 2003 | 0 | 1 | 1 | | 2004 | 2 | 1 | 3 | | 2005 | 2 | 3 | 5 | | 2006 | 0 | 3 | 3 | | 2007 | 2 | 4 | 6 | | 2008 | 1 | 5 | 6 | | 2009 | 1 | 3 | 4 | | 2010 | 1 | 1 | 2 | | 2011 | 3 | 5 | 8 | | 2012 | 0 | 2 | 2 | | 2013 | 3 | 3 | 6 | | 2014 | 1 | 4 | 5 | | 2015 | 1 | 1 | 2 | | 2016 | 2 | 1 | 3 | | 2017 | 1 | 3 | 4 | | 2020 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "NADPH Oxidases" by people in Profiles.
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Gibbings SL, Haist KC, Redente EF, Henson PM, Bratton DL. TNFa: TNFR1 signaling inhibits maturation and maintains the pro-inflammatory programming of monocyte-derived macrophages in murine chronic granulomatous disease. Front Immunol. 2024; 15:1354836.
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Kim JS, Liu L, Kant S, Orlicky DJ, Uppalapati S, Margolis A, Davenport BJ, Morrison TE, Matsuda J, McClelland M, Jones-Carson J, Vazquez-Torres A. Anaerobic respiration of host-derived methionine sulfoxide protects intracellular Salmonella from the phagocyte NADPH oxidase. Cell Host Microbe. 2024 Mar 13; 32(3):411-424.e10.
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Kant S, Liu L, Vazquez-Torres A. The methylglyoxal pathway is a sink for glutathione in Salmonella experiencing oxidative stress. PLoS Pathog. 2023 06; 19(6):e1011441.
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Kant S, Till JKA, Liu L, Margolis A, Uppalapati S, Kim JS, Vazquez-Torres A. Gre factors help Salmonella adapt to oxidative stress by improving transcription elongation and fidelity of metabolic genes. PLoS Biol. 2023 04; 21(4):e3002051.
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Gibbings SL, Haist KC, Nick H, Frasch SC, Glass TH, Vestal B, Danhorn T, Mould KJ, Henson PM, Bratton DL. Heightened turnover and failed maturation of monocyte-derived macrophages in murine chronic granulomatous disease. Blood. 2022 03 17; 139(11):1707-1721.
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Ambruso DR, Briones NJ, Baroffio AF, Murphy JR, Tran AD, Gowan K, Sanford B, Ellison M, Jones KL. In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype. PLoS One. 2022; 17(2):e0263370.
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Amjadi MF, Avner BS, Greenlee-Wacker MC, Horswill AR, Nauseef WM. Neutrophil-derived extracellular vesicles modulate the phenotype of na?ve human neutrophils. J Leukoc Biol. 2021 11; 110(5):917-925.
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Craighead DH, Freeberg KA, Seals DR. Vascular Endothelial Function in Midlife/Older Adults Classified According to 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines. J Am Heart Assoc. 2020 09; 9(17):e016625.
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Loth MK, Guariglia SR, Re DB, Perez J, de Paiva VN, Dziedzic JL, Chambers JW, Azzam DJ, Guilarte TR. A Novel Interaction of Translocator Protein 18?kDa (TSPO) with NADPH Oxidase in Microglia. Mol Neurobiol. 2020 Nov; 57(11):4467-4487.
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Ronis MJ, Blackburn ML, Shankar K, Ferguson M, Cleves MA, Badger TM. Estradiol and NADPH oxidase crosstalk regulates responses to high fat feeding in female mice. Exp Biol Med (Maywood). 2019 07; 244(10):834-845.
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