 NADPH Oxidases
"NADPH Oxidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
| Descriptor ID |
D019255
|
| MeSH Number(s) |
D08.811.682.608.575 D12.776.331.894 D12.776.543.653
|
| Concept/Terms |
NADPH Oxidases- NADPH Oxidases
- Oxidases, NADPH
- NAD(P)H oxidase
- NADPH Oxidase
- Oxidase, NADPH
- Nox Proteins
- NAD(P)H Oxidases
|
Below are MeSH descriptors whose meaning is more general than "NADPH Oxidases".
Below are MeSH descriptors whose meaning is more specific than "NADPH Oxidases".
This graph shows the total number of publications written about "NADPH Oxidases" by people in this website by year, and whether "NADPH Oxidases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1996 | 0 | 2 | 2 | | 1999 | 0 | 1 | 1 | | 2000 | 1 | 1 | 2 | | 2001 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 2 | 3 | | 2004 | 2 | 1 | 3 | | 2005 | 5 | 0 | 5 | | 2006 | 1 | 2 | 3 | | 2007 | 3 | 5 | 8 | | 2008 | 1 | 4 | 5 | | 2009 | 0 | 4 | 4 | | 2010 | 1 | 1 | 2 | | 2011 | 3 | 3 | 6 | | 2012 | 0 | 1 | 1 | | 2013 | 4 | 2 | 6 | | 2014 | 1 | 2 | 3 | | 2016 | 2 | 1 | 3 | | 2017 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 | | 2022 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "NADPH Oxidases" by people in Profiles.
-
Gibbings SL, Haist KC, Nick H, Frasch SC, Glass TH, Vestal B, Danhorn T, Mould KJ, Henson PM, Bratton DL. Heightened turnover and failed maturation of monocyte-derived macrophages in murine chronic granulomatous disease. Blood. 2022 03 17; 139(11):1707-1721.
-
Ambruso DR, Briones NJ, Baroffio AF, Murphy JR, Tran AD, Gowan K, Sanford B, Ellison M, Jones KL. In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype. PLoS One. 2022; 17(2):e0263370.
-
Amjadi MF, Avner BS, Greenlee-Wacker MC, Horswill AR, Nauseef WM. Neutrophil-derived extracellular vesicles modulate the phenotype of naïve human neutrophils. J Leukoc Biol. 2021 11; 110(5):917-925.
-
Craighead DH, Freeberg KA, Seals DR. Vascular Endothelial Function in Midlife/Older Adults Classified According to 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines. J Am Heart Assoc. 2020 09; 9(17):e016625.
-
Ronis MJ, Blackburn ML, Shankar K, Ferguson M, Cleves MA, Badger TM. Estradiol and NADPH oxidase crosstalk regulates responses to high fat feeding in female mice. Exp Biol Med (Maywood). 2019 07; 244(10):834-845.
-
Zgheib C, Hodges MM, Hu J, Liechty KW, Xu J. Long non-coding RNA Lethe regulates hyperglycemia-induced reactive oxygen species production in macrophages. PLoS One. 2017; 12(5):e0177453.
-
Grace PM, Gaudet AD, Staikopoulos V, Maier SF, Hutchinson MR, Salvemini D, Watkins LR. Nitroxidative Signaling Mechanisms in Pathological Pain. Trends Neurosci. 2016 12; 39(12):862-879.
-
Kelher MR, McLaughlin NJ, Banerjee A, Elzi DJ, Gamboni F, Khan SY, Meng X, Mitra S, Silliman CC. LysoPCs induce Hck- and PKCd-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol. 2017 01; 101(1):261-273.
-
Deep G, Kumar R, Jain AK, Dhar D, Panigrahi GK, Hussain A, Agarwal C, El-Elimat T, Sica VP, Oberlies NH, Agarwal R. Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity. Sci Rep. 2016 Mar 16; 6:23135.
-
Kumar R, Kohli S, Ali Z, Duhan K, Ram R, Gupta M, Tyagi S, Mohammad G, Pasha MQ. CYBA (p22phox) variants associate with blood pressure and oxidative stress markers in hypertension: a replication study in populations of diverse altitudes. Hypertens Res. 2015 Jul; 38(7):498-506.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|