 Cytochrome-B(5) Reductase
"Cytochrome-B(5) Reductase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
| Descriptor ID |
D042966
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| MeSH Number(s) |
D08.811.682.608.191.237 D12.776.331.186
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| Concept/Terms |
Cytochrome-B(5) Reductase- Cytochrome-B(5) Reductase
- NADH-Cytochrome B5 Reductase
- B5 Reductase, NADH-Cytochrome
- NADH Cytochrome B5 Reductase
Methemoglobin Reductase- Methemoglobin Reductase
- Reductase, Methemoglobin
- NADH-Ferrihemoglobin Reductase
- NADH Ferrihemoglobin Reductase
- Reductase, NADH-Ferrihemoglobin
- NADH Methemoglobin Reductase
- Methemoglobin Reductase, NADH
- Reductase, NADH Methemoglobin
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Below are MeSH descriptors whose meaning is more general than "Cytochrome-B(5) Reductase".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome-B(5) Reductase".
This graph shows the total number of publications written about "Cytochrome-B(5) Reductase" by people in this website by year, and whether "Cytochrome-B(5) Reductase" was a major or minor topic of these publications.
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Below are the most recent publications written about "Cytochrome-B(5) Reductase" by people in Profiles.
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Pink JJ, Planchon SM, Tagliarino C, Varnes ME, Siegel D, Boothman DA. NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J Biol Chem. 2000 Feb 25; 275(8):5416-24.
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Gustafson DL, Beall HD, Bolton EM, Ross D, Waldren CA. Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones. Mol Pharmacol. 1996 Oct; 50(4):728-35.
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Hall AH, Kulig KW, Rumack BH. Drug- and chemical-induced methaemoglobinaemia. Clinical features and management. Med Toxicol. 1986 Jul-Aug; 1(4):253-60.
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Harris JC, Rumack BH, Peterson RG, McGuire BM. Methemoglobinemia resulting from absorption of nitrates. JAMA. 1979 Dec 28; 242(26):2869-71.
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