 Catalytic Domain
"Catalytic Domain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
| Descriptor ID |
D020134
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| MeSH Number(s) |
G02.111.570.120.704 G02.111.570.820.709.275.750.188
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| Concept/Terms |
Catalytic Domain- Catalytic Domain
- Catalytic Domains
- Domain, Catalytic
- Domains, Catalytic
- Catalytic Subunit
- Catalytic Subunits
- Subunit, Catalytic
- Subunits, Catalytic
- Catalytic Region
- Catalytic Regions
- Region, Catalytic
- Regions, Catalytic
- Catalytic Core
- Catalytic Cores
- Core, Catalytic
- Cores, Catalytic
Active Site- Active Site
- Active Sites
- Site, Active
- Sites, Active
- Catalytic Site
- Catalytic Sites
- Site, Catalytic
- Sites, Catalytic
- Reactive Site
- Reactive Sites
- Site, Reactive
- Sites, Reactive
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Below are MeSH descriptors whose meaning is more general than "Catalytic Domain".
Below are MeSH descriptors whose meaning is more specific than "Catalytic Domain".
This graph shows the total number of publications written about "Catalytic Domain" by people in this website by year, and whether "Catalytic Domain" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 1 | 2 | | 1999 | 2 | 4 | 6 | | 2000 | 0 | 8 | 8 | | 2001 | 0 | 6 | 6 | | 2002 | 1 | 4 | 5 | | 2003 | 0 | 7 | 7 | | 2004 | 1 | 4 | 5 | | 2005 | 0 | 3 | 3 | | 2006 | 0 | 4 | 4 | | 2007 | 0 | 7 | 7 | | 2008 | 0 | 7 | 7 | | 2009 | 1 | 7 | 8 | | 2010 | 1 | 10 | 11 | | 2011 | 0 | 7 | 7 | | 2012 | 2 | 13 | 15 | | 2013 | 1 | 17 | 18 | | 2014 | 2 | 9 | 11 | | 2015 | 0 | 15 | 15 | | 2016 | 2 | 7 | 9 | | 2017 | 0 | 9 | 9 | | 2018 | 1 | 9 | 10 | | 2019 | 0 | 6 | 6 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Catalytic Domain" by people in Profiles.
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Zhang J, Balsbaugh JL, Gao S, Ahn NG, Klinman JP. Hydrogen deuterium exchange defines catalytically linked regions of protein flexibility in the catechol O-methyltransferase reaction. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):10797-10805.
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Prates ET, Crowley MF, Skaf MS, Beckham GT. Catalytic Mechanism of Aryl-Ether Bond Cleavage in Lignin by LigF and LigG. J Phys Chem B. 2019 12 05; 123(48):10142-10151.
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Vermaas JV, Kont R, Beckham GT, Crowley MF, Gudmundsson M, Sandgren M, Ståhlberg J, Väljamäe P, Knott BC. The dissociation mechanism of processive cellulases. Proc Natl Acad Sci U S A. 2019 11 12; 116(46):23061-23067.
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Pegram LM, Liddle JC, Xiao Y, Hoh M, Rudolph J, Iverson DB, Vigers GP, Smith D, Zhang H, Wang W, Moffat JG, Ahn NG. Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2. Proc Natl Acad Sci U S A. 2019 07 30; 116(31):15463-15468.
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El Bakkouri M, Kouidmi I, Wernimont AK, Amani M, Hutchinson A, Loppnau P, Kim JJ, Flueck C, Walker JR, Seitova A, Senisterra G, Kakihara Y, Kim C, Blackman MJ, Calmettes C, Baker DA, Hui R. Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):14164-14173.
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Raeeszadeh-Sarmazdeh M, Greene KA, Sankaran B, Downey GP, Radisky DC, Radisky ES. Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition. J Biol Chem. 2019 06 14; 294(24):9476-9488.
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Zhang Y, Klein BJ, Cox KL, Bertulat B, Tencer AH, Holden MR, Wright GM, Black J, Cardoso MC, Poirier MG, Kutateladze TG. Mechanism for autoinhibition and activation of the MORC3 ATPase. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6111-6119.
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Bester SM, Guelta MA, Cheung J, Winemiller MD, Bae SY, Myslinski J, Pegan SD, Height JJ. Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6. Chem Res Toxicol. 2018 12 17; 31(12):1405-1417.
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Romero Romero ML, Yang F, Lin YR, Toth-Petroczy A, Berezovsky IN, Goncearenco A, Yang W, Wellner A, Kumar-Deshmukh F, Sharon M, Baker D, Varani G, Tawfik DS. Simple yet functional phosphate-loop proteins. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E11943-E11950.
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Hjortness MK, Riccardi L, Hongdusit A, Zwart PH, Sankaran B, De Vivo M, Fox JM. Evolutionarily Conserved Allosteric Communication in Protein Tyrosine Phosphatases. Biochemistry. 2018 11 13; 57(45):6443-6451.
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