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Search Results to Lynn E Heasley

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Heasley, Lynn

One or more keywords matched the following items that are connected to Heasley, Lynn

Item Type	Name
Academic Article	Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation.
Academic Article	Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes.
Academic Article	gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation.
Academic Article	Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of G alpha 12 and G alpha 13.
Academic Article	The beta-PDGF receptor induces neuronal differentiation of PC12 cells.
Academic Article	Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.
Academic Article	Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH 3T3 and rat 1a cells.
Academic Article	GTPase-deficient G alpha 16 and G alpha q induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinases.
Academic Article	Multiple mitogen-activated protein kinases are regulated by hyperosmolality in mouse IMCD cells.
Academic Article	c-Jun NH2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation.
Academic Article	Dominant-negative c-Jun NH2-terminal kinase 2 sensitizes renal inner medullary collecting duct cells to hypertonicity-induced lethality independent of organic osmolyte transport.
Academic Article	Expression of catalytically inactive phospholipase Cbeta disrupts phospholipase Cbeta and mitogen-activated protein kinase signaling and inhibits small cell lung cancer growth.
Academic Article	Expression of GTPase-deficient Ras inhibits vasopressin signaling in cultured cortical collecting duct cells.
Academic Article	Hormonal regulation of MAP kinase in cultured rat inner medullary collecting tubule cells.
Academic Article	New therapeutic strategies for lung cancer: biology and molecular biology come of age.
Academic Article	MAPK mediation of hypertonicity-stimulated cyclooxygenase-2 expression in renal medullary collecting duct cells.
Academic Article	Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes.
Academic Article	Isoforms of Jun kinase are differentially expressed and activated in human monocyte/macrophage (THP-1) cells.
Academic Article	Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation.
Academic Article	Collaboration of JNKs and ERKs in nerve growth factor regulation of the neurofilament light chain promoter in PC12 cells.
Academic Article	Galpha16 mimics vasoconstrictor action to induce smooth muscle alpha-actin in vascular smooth muscle cells through a Jun-NH2-terminal kinase-dependent pathway.
Academic Article	In vivo regulation of MAP kinases in Ratus norvegicus renal papilla by water loading and restriction.
Academic Article	Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells.
Academic Article	Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation.
Academic Article	The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer.
Academic Article	Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model.
Academic Article	Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression.
Academic Article	TRH regulates Kv1.5 gene expression through a Galphaq-mediated PLC-independent pathway.
Academic Article	Protein kinase C d is a downstream effector of oncogenic K-ras in lung tumors.
Academic Article	Induction of cytosolic phospholipase A2 by oncogenic Ras is mediated through the JNK and ERK pathways in rat epithelial cells.
Academic Article	Prolactin stimulates activation of c-jun N-terminal kinase (JNK).
Academic Article	Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.
Academic Article	Detection of nerve growth factor and epidermal growth factor-regulated protein kinases in PC12 cells with synthetic peptide substrates.
Academic Article	Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells.
Academic Article	Differential modulation of bombesin-stimulated phospholipase C beta and mitogen-activated protein kinase activity by [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P.
Academic Article	MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts.
Academic Article	Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation.
Academic Article	Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases.
Academic Article	Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.
Academic Article	Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms.
Academic Article	Inhibited neurogenesis in JNK1-deficient embryonic stem cells.
Academic Article	JNK regulation of oncogenesis.
Academic Article	Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.
Academic Article	Akt negatively regulates the cJun N-terminal kinase pathway in PC12 cells.
Academic Article	Interferon-beta-induced activation of c-Jun NH2-terminal kinase mediates apoptosis through up-regulation of CD95 in CH31 B lymphoma cells.
Academic Article	Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma.
Academic Article	Concise review: regulation of embryonic stem cell lineage commitment by mitogen-activated protein kinases.
Academic Article	Chimeras of the Gs alpha subunit that had the NH2- or COOH-terminal sequence substituted for the corresponding region of the Gi alpha subunit constitutively activate adenylyl cyclase.
Academic Article	Mutation of glycine 49 to valine in the alpha subunit of GS results in the constitutive elevation of cyclic AMP synthesis.
Academic Article	Analysis of Wnt7a-stimulated JNK activity and cJun phosphorylation in non-small cell lung cancer cells.
Academic Article	Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells.
Academic Article	A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines.
Concept	MAP Kinase Signaling System
Concept	Protein Kinase C
Concept	Phosphotransferases (Alcohol Group Acceptor)
Concept	Mitogen-Activated Protein Kinase 8
Concept	Protein-Tyrosine Kinases
Concept	Mitogen-Activated Protein Kinases
Concept	Calcium-Calmodulin-Dependent Protein Kinases
Concept	p38 Mitogen-Activated Protein Kinases
Concept	MAP Kinase Kinase 7
Concept	Mitogen-Activated Protein Kinase Kinases
Concept	MAP Kinase Kinase Kinase 4
Concept	Receptor Protein-Tyrosine Kinases
Concept	Mitogen-Activated Protein Kinase 7
Concept	Receptor Tyrosine Kinase-like Orphan Receptors
Concept	Protein Kinase Inhibitors
Concept	Cyclin-Dependent Kinase Inhibitor p21
Concept	Mitogen-Activated Protein Kinase 1
Concept	Mitogen-Activated Protein Kinase 9
Concept	src-Family Kinases
Concept	Cyclic AMP-Dependent Protein Kinases
Concept	Protein Kinases
Concept	Extracellular Signal-Regulated MAP Kinases
Concept	JNK Mitogen-Activated Protein Kinases
Concept	Mitogen-Activated Protein Kinase 10
Concept	Mitogen-Activated Protein Kinase 3
Concept	MAP Kinase Kinase 4
Concept	Phosphatidylinositol 3-Kinases
Concept	Protein Kinase C-delta
Concept	Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Academic Article	Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer.
Academic Article	Heterotrimeric G-protein, Ga16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.
Academic Article	Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer.
Academic Article	Hypoxia regulates alternative splicing of HIF and non-HIF target genes.
Academic Article	FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies.
Academic Article	Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy.
Academic Article	Nonamplified FGFR1 is a growth driver in malignant pleural mesothelioma.
Academic Article	An Inducible TGF-?2-TGF?R Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.
Academic Article	FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers.
Academic Article	Identifying kinase dependency in cancer cells by integrating high-throughput drug screening and kinase inhibition data.
Academic Article	Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC.
Academic Article	An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer.
Academic Article	MERTK as a novel therapeutic target in head and neck cancer.
Academic Article	PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines.
Academic Article	Co-dependency of PKCd and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer.
Grant	FGF-2 Autocrine Signaling in Lung Cancer
Grant	An FGFR1 oncogene driver pathway in head and neck cancer
Grant	Role of JNK Pathway in Lung Tumorigenesis
Grant	Integrated MAP Kinase Signaling In Cell Differentiation
Grant	PERSISTENT KINASE SIGNALS IN PC12 CELL DIFFERENTIATION
Grant	MAP KINASES AS MEDIATORS OF DIABETIC NEUROPATHY
Academic Article	EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases.
Academic Article	Analysis of Drug Resistance Using Kinome-Wide Functional Screens.
Academic Article	Mechanisms of rapid cancer cell reprogramming initiated by targeted receptor tyrosine kinase inhibitors and inherent therapeutic vulnerabilities.
Academic Article	Role of EphB3 Receptor in Mediating Head and Neck Tumor Growth, Cell Migration, and Response to PI3K Inhibitor.
Academic Article	Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia.
Academic Article	Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) ? Isoform are Regulated through Binding to the Phosphatase Calcineurin.
Academic Article	Linking tyrosine kinase inhibitor-mediated inflammation with normal epithelial cell homeostasis and tumor therapeutic responses.
Concept	Class I Phosphatidylinositol 3-Kinases
Concept	c-Mer Tyrosine Kinase
Concept	TOR Serine-Threonine Kinases
Academic Article	Therapeutic opportunity in innate immune response induction by oncogene-targeted drugs.
Academic Article	Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines.
Academic Article	Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms.
Academic Article	A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer.
Academic Article	Novel EGFR-mutant mouse models of lung adenocarcinoma reveal adaptive immunity requirement for durable osimertinib response.
Academic Article	A functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes.

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