 Mitogen-Activated Protein Kinase 7
"Mitogen-Activated Protein Kinase 7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 110-kDa extracellular signal-regulated MAP kinase that is activated in response to cellular stress and by GROWTH FACTOR RECEPTORS-mediated pathways.
| Descriptor ID |
D048054
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| MeSH Number(s) |
D08.811.913.696.620.682.700.567.249.937 D12.644.360.450.169.937 D12.776.476.450.169.937
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| Concept/Terms |
Mitogen-Activated Protein Kinase 7- Mitogen-Activated Protein Kinase 7
- Mitogen Activated Protein Kinase 7
- Extracellular Signal-Regulated Kinase 5
- Extracellular Signal Regulated Kinase 5
- MAPK7 Mitogen-Activated Protein Kinase
- MAPK7 Mitogen Activated Protein Kinase
- ERK5 Kinase
- Kinase, ERK5
- Big MAP Kinase 1
- BMK1 Kinase
- Kinase, BMK1
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Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 7".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 7".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 7" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 7" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2000 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 2 | 1 | 3 | | 2007 | 1 | 0 | 1 | | 2011 | 2 | 0 | 2 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinase 7" by people in Profiles.
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Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Moczygemba M, Isgandarova S, Schadler KL, Chung C, Milgrom SA, Banchs J, Yusuf SW, Amaya DN, Guo H, Thomas TN, Shen YH, Deswal A, Herrmann J, Kleinerman ES, Entman ML, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Gupte AA, Krishnan S, Patel ZS, Yoon Y, Burks JK, Fujiwara K, Brookes PS, Le NT, Hamilton DJ, Abe JI. Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. Redox Biol. 2021 11; 47:102132.
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Saleiro D, Blyth GT, Kosciuczuk EM, Ozark PA, Majchrzak-Kita B, Arslan AD, Fischietti M, Reddy NK, Horvath CM, Davis RJ, Fish EN, Platanias LC. IFN-?-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5. Sci Signal. 2018 11 20; 11(557).
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Stankiewicz TR, Ramaswami SA, Bouchard RJ, Aktories K, Linseman DA. Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. J Biol Chem. 2015 Apr 10; 290(15):9363-76.
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Mackesy DZ, Goalstone ML. Extracellular signal-regulated kinase-5: Novel mediator of insulin and tumor necrosis factor a-stimulated vascular cell adhesion molecule-1 expression in vascular cells. J Diabetes. 2014 Nov; 6(6):595-602.
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Avasarala S, Bikkavilli RK, Van Scoyk M, Zhang W, Lapite A, Hostetter L, Byers JT, Heasley LE, Sohn JW, Winn RA. Heterotrimeric G-protein, Ga16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer. PLoS One. 2013; 8(10):e76895.
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Brown RD, Ambler SK, Li M, Sullivan TM, Henry LN, Crossno JT, Long CS, Garrington TP, Stenmark KR. MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2013 Jan 15; 304(2):H269-81.
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Waldron T, De Dominici M, Soliera AR, Audia A, Iacobucci I, Lonetti A, Martinelli G, Zhang Y, Martinez R, Hyslop T, Bender TP, Calabretta B. c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells. Leukemia. 2012 Apr; 26(4):644-53.
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Goalstone ML. ERK5: a novel IKKa-kinase in rat hippocampal neurons. Can J Neurol Sci. 2011 Jul; 38(4):639-48.
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Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR. A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. Blood. 2009 Nov 12; 114(20):4592-600.
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Sharma G, Goalstone ML. Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells. Biochem Biophys Res Commun. 2007 Mar 23; 354(4):1078-83.
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