 Receptors, Bradykinin
"Receptors, Bradykinin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell surface receptors that bind BRADYKININ and related KININS with high affinity and trigger intracellular changes which influence the behavior of cells. The identified receptor types (B-1 and B-2, or BK-1 and BK-2) recognize endogenous KALLIDIN; t-kinins; and certain bradykinin fragments as well as bradykinin itself.
| Descriptor ID |
D018002
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| MeSH Number(s) |
D12.776.543.750.695.080 D12.776.543.750.720.600.220 D12.776.543.750.750.555.220
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Receptors, Bradykinin".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Bradykinin [D12.776.543.750.695.080]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Neuropeptide [D12.776.543.750.720.600]
- Receptors, Bradykinin [D12.776.543.750.720.600.220]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Neuropeptide [D12.776.543.750.750.555]
- Receptors, Bradykinin [D12.776.543.750.750.555.220]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Bradykinin".
This graph shows the total number of publications written about "Receptors, Bradykinin" by people in this website by year, and whether "Receptors, Bradykinin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 | | 2002 | 0 | 2 | 2 | | 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptors, Bradykinin" by people in Profiles.
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Gera L, Roy C, Bawolak MT, Charest-Morin X, Marceau F. N-terminal extended conjugates of the agonists and antagonists of both bradykinin receptor subtypes: structure-activity relationship, cell imaging using ligands conjugated with fluorophores and prospect for functionally active cargoes. Peptides. 2012 Apr; 34(2):433-46.
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Gera L, Roy C, Bawolak MT, Bouthillier J, Adam A, Marceau F. Met-Lys-bradykinin-Ser-Ser, a peptide produced by the neutrophil from kininogen, is metabolically activated by angiotensin converting enzyme in vascular tissue. Pharmacol Res. 2011 Nov; 64(5):528-34.
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Jutras S, Bachvarova M, Keita M, Bascands JL, Mes-Masson AM, Stewart JM, Gera L, Bachvarov D. Strong cytotoxic effect of the bradykinin antagonist BKM-570 in ovarian cancer cells--analysis of the molecular mechanisms of its antiproliferative action. FEBS J. 2010 Dec; 277(24):5146-60.
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Arndt PG, Young SK, Poch KR, Nick JA, Falk S, Schrier RW, Worthen GS. Systemic inhibition of the angiotensin-converting enzyme limits lipopolysaccharide-induced lung neutrophil recruitment through both bradykinin and angiotensin II-regulated pathways. J Immunol. 2006 Nov 15; 177(10):7233-41.
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Schroeder C, Breit A, B?ning H, Dedio J, Gera L, Stewart J, M?ller-Esterl W. Changes in amino-terminal portion of human B2 receptor selectively increase efficacy of synthetic ligand HOE 140 but not of cognate ligand bradykinin. Am J Physiol Heart Circ Physiol. 2003 Jun; 284(6):H1924-32.
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Stewart JM, Chan DC, Simkeviciene V, Bunn PA, Helfrich B, York EJ, Taraseviciene-Stewart L, Bironaite D, Gera L. Bradykinin antagonists as new drugs for prostate cancer. Int Immunopharmacol. 2002 Dec; 2(13-14):1781-6.
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Taraseviciene-Stewart L, Gera L, Hirth P, Voelkel NF, Tuder RM, Stewart JM. A bradykinin antagonist and a caspase inhibitor prevent severe pulmonary hypertension in a rat model. Can J Physiol Pharmacol. 2002 Apr; 80(4):269-74.
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Banik RK, Kozaki Y, Sato J, Gera L, Mizumura K. B2 receptor-mediated enhanced bradykinin sensitivity of rat cutaneous C-fiber nociceptors during persistent inflammation. J Neurophysiol. 2001 Dec; 86(6):2727-35.
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Yang XP, Liu YH, Mehta D, Cavasin MA, Shesely E, Xu J, Liu F, Carretero OA. Diminished cardioprotective response to inhibition of angiotensin-converting enzyme and angiotensin II type 1 receptor in B(2) kinin receptor gene knockout mice. Circ Res. 2001 May 25; 88(10):1072-9.
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Wieczorek M, Pilyavskaya A, Burkard M, Zuzack JS, Jones SW, Francis MD, Beckey VE, Ross SE, Goodfellow VS, Fitzpatrick TD, Marathe MV, Gyorkos A, Spruce LW, Selig WM, Stewart JM, Gera L, Whalley ET. Bradykinin antagonists in human systems: correlation between receptor binding, calcium signalling in isolated cells, and functional activity in isolated ileum. Biochem Pharmacol. 1997 Jul 15; 54(2):283-91.
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