 Potassium Channel Blockers
"Potassium Channel Blockers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.
| Descriptor ID |
D026902
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| MeSH Number(s) |
D27.505.519.562.500 D27.505.954.411.645
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Potassium Channel Blockers".
Below are MeSH descriptors whose meaning is more specific than "Potassium Channel Blockers".
This graph shows the total number of publications written about "Potassium Channel Blockers" by people in this website by year, and whether "Potassium Channel Blockers" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 1 | 1 | 2 | | 2001 | 1 | 2 | 3 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 4 | 5 | | 2013 | 0 | 5 | 5 | | 2014 | 0 | 2 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Potassium Channel Blockers" by people in Profiles.
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Kushner JK, Hoffman PB, Brzezinski CR, O'Neill BR, Hankinson TC, Wilkinson CC, Handler MH, Hoeffer CA, Alexander AL. 4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2-5 (Kv7.2-Kv7.5) channels. Neurobiol Dis. 2026 Jan; 218:107252.
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Ruiz-Pick YI, Richey RE, Garfield TC, Kichloo A, Olivencia-Yurvati AH, Dick GM, Romero SA. KV channel antagonism blunts vasodilatation in skeletal muscle of humans. J Physiol. 2025 Nov; 603(22):6801-6810.
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Aretz CD, Vadukoot AK, Hopkins CR. Discovery of Small Molecule Renal Outer Medullary Potassium (ROMK) Channel Inhibitors: A Brief History of Medicinal Chemistry Approaches To Develop Novel Diuretic Therapeutics. J Med Chem. 2019 10 10; 62(19):8682-8694.
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Modrak M, Sundem L, Gupta R, Zuscik MJ, Elfar J. Pharmacological Attenuation of Electrical Effects in a Model of Compression Neuropathy. J Bone Joint Surg Am. 2019 Mar 20; 101(6):523-530.
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Hearon CM, Richards JC, Racine ML, Luckasen GJ, Larson DG, Dinenno FA. Amplification of endothelium-dependent vasodilatation in contracting human skeletal muscle: role of KIR channels. J Physiol. 2019 03; 597(5):1321-1335.
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Guo A, Niyazov A, Macaulay D, Terasawa E, Schmerold L, Wu EQ, Krieger S. Inpatient Admissions and Costs Associated with Persistent Use of Dalfampridine Extended-Release in Multiple Sclerosis: A Claims Database Analysis. J Manag Care Spec Pharm. 2017 Jul; 23(7):771-780.
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Tseng KC, Li H, Clark A, Sundem L, Zuscik M, Noble M, Elfar J. 4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury. EMBO Mol Med. 2016 12; 8(12):1409-1420.
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Holdsworth CT, Ferguson SK, Poole DC, Musch TI. Modulation of rat skeletal muscle microvascular O2 pressure via KATP channel inhibition following the onset of contractions. Respir Physiol Neurobiol. 2016 Feb 01; 222:48-54.
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Simpson DM, Goldenberg J, Kasner S, Nash M, Reding MJ, Zweifler RM, Suarez G, Zhao P, Henney HR, Rabinowicz AL, Carrazana E. Dalfampridine in chronic sensorimotor deficits after ischemic stroke: A proof of concept study. J Rehabil Med. 2015 11; 47(10):924-31.
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Shiraishi T, Tamura Y, Taniguchi K, Higaki M, Ueda S, Shima T, Nagura M, Nakagawa T, Johnson RJ, Uchida S. Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1313-22.
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