 Frizzled Receptors
"Frizzled Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of seven-pass transmembrane cell-surface proteins that combines with LOW DENSITY LIPROTEIN RECEPTOR-RELATED PROTEIN-5 or LOW DENSITY LIPROTEIN RECEPTOR-RELATED PROTEIN-5 to form receptors for WNT PROTEINS. Frizzled receptors often couple with HETEROTRIMERIC G PROTEINS and regulate the WNT SIGNALING PATHWAY.
| Descriptor ID |
D051157
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| MeSH Number(s) |
D12.776.543.750.695.017 D12.776.543.750.850.500
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| Concept/Terms |
Frizzled Receptors- Frizzled Receptors
- Frizzled Receptor
- Receptor, Frizzled
- Receptors, Frizzled
- Frizzled Proteins
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Below are MeSH descriptors whose meaning is more general than "Frizzled Receptors".
Below are MeSH descriptors whose meaning is more specific than "Frizzled Receptors".
This graph shows the total number of publications written about "Frizzled Receptors" by people in this website by year, and whether "Frizzled Receptors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2010 | 1 | 1 | 2 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 2 | 0 | 2 | | 2020 | 0 | 1 | 1 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Frizzled Receptors" by people in Profiles.
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Smith AJ, Do P, Sompel K, Elango A, Tennis MA. miR-520a-5p regulates Frizzled 9 expression and mediates effects of cigarette smoke and iloprost chemoprevention. Sci Rep. 2022 02 11; 12(1):2388.
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Vladar EK, K?nigshoff M. Noncanonical Wnt planar cell polarity signaling in lung development and disease. Biochem Soc Trans. 2020 02 28; 48(1):231-243.
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Wang Y, Cho C, Williams J, Smallwood PM, Zhang C, Junge HJ, Nathans J. Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proc Natl Acad Sci U S A. 2018 12 11; 115(50):E11827-E11836.
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Skronska-Wasek W, Mutze K, Baarsma HA, Bracke KR, Alsafadi HN, Lehmann M, Costa R, Stornaiuolo M, Novellino E, Brusselle GG, Wagner DE, Yildirim A?, K?nigshoff M. Reduced Frizzled Receptor 4 Expression Prevents WNT/?-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 07 15; 196(2):172-185.
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Zhang C, Lai MB, Khandan L, Lee LA, Chen Z, Junge HJ. Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function. Nat Commun. 2017 07 04; 8:16050.
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Lai MB, Zhang C, Shi J, Johnson V, Khandan L, McVey J, Klymkowsky MW, Chen Z, Junge HJ. TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling. Cell Rep. 2017 06 27; 19(13):2809-2822.
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Tennis MA, New ML, McArthur DG, Merrick DT, Dwyer-Nield LD, Keith RL. Prostacyclin reverses the cigarette smoke-induced decrease in pulmonary Frizzled 9 expression through miR-31. Sci Rep. 2016 06 24; 6:28519.
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Lee HJ, Bao J, Miller A, Zhang C, Wu J, Baday YC, Guibao C, Li L, Wu D, Zheng JJ. Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. J Biol Chem. 2015 Dec 18; 290(51):30596-606.
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Vladar EK, Lee YL, Stearns T, Axelrod JD. Observing planar cell polarity in multiciliated mouse airway epithelial cells. Methods Cell Biol. 2015; 127:37-54.
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Yuan K, Orcholski ME, Panaroni C, Shuffle EM, Huang NF, Jiang X, Tian W, Vladar EK, Wang L, Nicolls MR, Wu JY, de Jesus Perez VA. Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis. Am J Pathol. 2015 Jan; 185(1):69-84.
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