 Chromatin Assembly Factor-1
"Chromatin Assembly Factor-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A histone chaperone protein that plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA. It is comprised of three different subunits of 48, 60, and 150 kDa molecular size. The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling.
| Descriptor ID |
D056504
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| MeSH Number(s) |
D12.776.580.219.200
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| Concept/Terms |
Chromatin Assembly Factor-1- Chromatin Assembly Factor-1
- Assembly Factor-1, Chromatin
- Chromatin Assembly Factor 1
- Chromatin Assembly Complex-1
- Assembly Complex-1, Chromatin
- Chromatin Assembly Complex 1
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Below are MeSH descriptors whose meaning is more general than "Chromatin Assembly Factor-1".
Below are MeSH descriptors whose meaning is more specific than "Chromatin Assembly Factor-1".
This graph shows the total number of publications written about "Chromatin Assembly Factor-1" by people in this website by year, and whether "Chromatin Assembly Factor-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 1 | 2 | | 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Chromatin Assembly Factor-1" by people in Profiles.
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Rosas R, Aguilar RR, Arslanovic N, Seck A, Smith DJ, Tyler JK, Churchill MEA. A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function. Elife. 2023 07 11; 12.
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Workalemahu T, Dalton S, Son SL, Allshouse A, Carey AZ, Page JM, Blue NR, Thorsten V, Goldenberg RL, Pinar H, Reddy UM, Silver RM. Copy number variants and fetal structural abnormalities in stillborn fetuses: A secondary analysis of the Stillbirth Collaborative Research Network study. BJOG. 2024 Jan; 131(2):157-162.
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Sauer PV, Gu Y, Liu WH, Mattiroli F, Panne D, Luger K, Churchill ME. Mechanistic insights into histone deposition and nucleosome assembly by the chromatin assembly factor-1. Nucleic Acids Res. 2018 11 02; 46(19):9907-9917.
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Campbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJ. NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins. Elife. 2018 03 13; 7.
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Mattiroli F, Gu Y, Balsbaugh JL, Ahn NG, Luger K. The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1. Sci Rep. 2017 04 18; 7:46274.
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Mattiroli F, Gu Y, Yadav T, Balsbaugh JL, Harris MR, Findlay ES, Liu Y, Radebaugh CA, Stargell LA, Ahn NG, Whitehouse I, Luger K. DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNA replication. Elife. 2017 03 18; 6.
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Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, Rathert P, Jude J, Ferrari F, Blanco A, Fellner M, Wenzel D, Zinner M, Vidal SE, Bell O, Stadtfeld M, Chang HY, Almouzni G, Lowe SW, Rinn J, Wernig M, Aravin A, Shi Y, Park PJ, Penninger JM, Zuber J, Hochedlinger K. The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 2015 Dec 10; 528(7581):218-24.
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Liu WH, Roemer SC, Port AM, Churchill ME. CAF-1-induced oligomerization of histones H3/H4 and mutually exclusive interactions with Asf1 guide H3/H4 transitions among histone chaperones and DNA. Nucleic Acids Res. 2012 12; 40(22):11229-39.
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