 Ubiquitin
"Ubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
| Descriptor ID |
D025801
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| MeSH Number(s) |
D12.776.947.500
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| Concept/Terms |
Ubiquitin- Ubiquitin
- ATP-Dependent Proteolysis Factor 1
- ATP Dependent Proteolysis Factor 1
- HMG-20
- APF-1
- High Mobility Protein 20
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Below are MeSH descriptors whose meaning is more general than "Ubiquitin".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin".
This graph shows the total number of publications written about "Ubiquitin" by people in this website by year, and whether "Ubiquitin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 1 | 2 | | 2004 | 1 | 6 | 7 | | 2005 | 2 | 1 | 3 | | 2006 | 0 | 3 | 3 | | 2007 | 1 | 4 | 5 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 1 | 2 | 3 | | 2011 | 1 | 6 | 7 | | 2012 | 2 | 3 | 5 | | 2013 | 0 | 2 | 2 | | 2014 | 2 | 0 | 2 | | 2015 | 0 | 1 | 1 | | 2017 | 0 | 3 | 3 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 2 | 2 | 4 | | 2021 | 0 | 1 | 1 | | 2022 | 2 | 3 | 5 |
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Below are the most recent publications written about "Ubiquitin" by people in Profiles.
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Han KJ, Mikalayeva V, Gerber SA, Kettenbach AN, Skeberdis VA, Prekeris R. Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation. Life Sci Alliance. 2022 09; 5(9).
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Song A, Wen AQ, Wen YE, Dzieciatkowska M, Kellems RE, Juneja HS, D'Alessandro A, Xia Y. p97 dysfunction underlies a loss of quality control of damaged membrane proteins and promotes oxidative stress and sickling in sickle cell disease. FASEB J. 2022 05; 36(5):e22246.
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Tencer AH, Liu J, Zhu J, Burkholder NT, Zhang Y, Wu W, Strahl BD, Ohta T, Kutateladze TG. The ZZ domain of HERC2 is a receptor of arginylated substrates. Sci Rep. 2022 04 11; 12(1):6063.
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Freitas BT, Ahiadorme DA, Bagul RS, Durie IA, Ghosh S, Hill J, Kramer NE, Murray J, O'Boyle BM, Onobun E, Pirrone MG, Shepard JD, Enos S, Subedi YP, Upadhyaya K, Tripp RA, Cummings BS, Crich D, Pegan SD. Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses. ACS Infect Dis. 2022 03 11; 8(3):596-611.
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Shepard JD, Freitas BT, Rodriguez SE, Scholte FEM, Baker K, Hutchison MR, Longo JE, Miller HC, O'Boyle BM, Tandon A, Zhao P, Grimsey NJ, Wells L, Bergeron ?, Pegan SD. The Structure and Immune Regulatory Implications of the Ubiquitin-Like Tandem Domain Within an Avian 2'-5' Oligoadenylate Synthetase-Like Protein. Front Immunol. 2021; 12:794664.
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Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, Nogales E. JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science. 2021 01 22; 371(6527).
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Dzimianski JV, Mace SL, Williams IL, Freitas BT, Pegan SD. Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis. Acta Crystallogr D Struct Biol. 2020 Nov 01; 76(Pt 11):1114-1123.
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Zavortink M, Rutt LN, Dzitoyeva S, Henriksen JC, Barrington C, Bilodeau DY, Wang M, Chen XXL, Rissland OS. The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition. Elife. 2020 06 23; 9.
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Freitas BT, Durie IA, Murray J, Longo JE, Miller HC, Crich D, Hogan RJ, Tripp RA, Pegan SD. Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease. ACS Infect Dis. 2020 08 14; 6(8):2099-2109.
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Buysse D, Pfitzner AK, West M, Roux A, Odorizzi G. The ubiquitin hydrolase Doa4 directly binds Snf7 to inhibit recruitment of ESCRT-III remodeling factors in S. cerevisiae. J Cell Sci. 2020 04 28; 133(8).
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