 Ubiquitin
"Ubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
| Descriptor ID |
D025801
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| MeSH Number(s) |
D12.776.947.500
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| Concept/Terms |
Ubiquitin- Ubiquitin
- ATP-Dependent Proteolysis Factor 1
- ATP Dependent Proteolysis Factor 1
- HMG-20
- APF-1
- High Mobility Protein 20
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Below are MeSH descriptors whose meaning is more general than "Ubiquitin".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin".
This graph shows the total number of publications written about "Ubiquitin" by people in this website by year, and whether "Ubiquitin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2002 | 0 | 1 | 1 | | 2003 | 1 | 1 | 2 | | 2004 | 1 | 6 | 7 | | 2005 | 2 | 1 | 3 | | 2006 | 0 | 3 | 3 | | 2007 | 3 | 3 | 6 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 3 | 4 | | 2010 | 0 | 2 | 2 | | 2011 | 1 | 8 | 9 | | 2012 | 2 | 4 | 6 | | 2013 | 0 | 2 | 2 | | 2014 | 2 | 0 | 2 | | 2015 | 1 | 1 | 2 | | 2017 | 0 | 5 | 5 | | 2018 | 1 | 1 | 2 | | 2019 | 0 | 1 | 1 | | 2020 | 0 | 3 | 3 | | 2021 | 0 | 5 | 5 | | 2022 | 1 | 4 | 5 | | 2023 | 2 | 1 | 3 | | 2024 | 0 | 3 | 3 | | 2025 | 0 | 1 | 1 | | 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ubiquitin" by people in Profiles.
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Zhang H, Wei T, Panchenko AR, Musselman CA, Peng Y. MD2NMR: Linking molecular dynamics with NMR relaxation. Biophys J. 2026 Jun 02; 125(11):2555-2566.
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Kim SH, Nouws J, Ruwisch J, Woodard GA, Cooley J, Khoury J, Sun H, Doherty E, Piecychna M, Manning EP, Kang MJ, Bruscia EM, Wei H, Zhang Y, Yarovinsky TO, Hwa J, Zacharias WJ, Ingram J, Lee CG, Elias JA, Kaminski N, Redente EF, Herzog EL, Prasse A, Bucala R, Sauler M. Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor-CD74 signaling. Sci Transl Med. 2025 Dec 03; 17(827):eadr2277.
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Rutherford KA, McManus KJ. PROTACs: Current and Future Potential as a Precision Medicine Strategy to Combat Cancer. Mol Cancer Ther. 2024 04 02; 23(4):454-463.
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Lu X, Chandravanshi M, Sabbasani VR, Gaikwad S, Hughitt VK, Gyabaah-Kessie N, Scroggins BT, Das S, Myint W, Clapp ME, Schwieters CD, Dyba MA, Bolhuis DL, Koscielniak JW, Andresson T, Emanuele MJ, Brown NG, Matsuo H, Chari R, Citrin DE, Mock BA, Swenson RE, Walters KJ. A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins. Nat Commun. 2024 Mar 20; 15(1):2485.
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Bolhuis DL, Emanuele MJ, Brown NG. Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases. Biochem Soc Trans. 2024 02 28; 52(1):241-267.
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Ledvin L, Gassaway BM, Tawil J, Urso O, Pizzo D, Welsh KA, Bolhuis DL, Fisher D, Bonni A, Gygi SP, Brown NG, Ferguson CJ. The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment. Dev Cell. 2023 12 04; 58(23):2666-2683.e9.
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Bodrug T, Welsh KA, Bolhuis DL, Paul?konis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG. Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nat Struct Mol Biol. 2023 11; 30(11):1663-1674.
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Hodáková Z, Grishkovskaya I, Brunner HL, Bolhuis DL, Belacic K, Schleiffer A, Kotisch H, Brown NG, Haselbach D. Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5. EMBO J. 2023 08 15; 42(16):e113348.
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Bolhuis DL, Martinez-Chacin RC, Welsh KA, Bodrug T, Cui L, Emanuele MJ, Brown NG. Examining the mechanistic relationship of APC/CCDH1 and its interphase inhibitor EMI1. Protein Sci. 2022 06; 31(6):e4324.
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Han KJ, Mikalayeva V, Gerber SA, Kettenbach AN, Skeberdis VA, Prekeris R. Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation. Life Sci Alliance. 2022 09; 5(9).
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