 Polyubiquitin
"Polyubiquitin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An oligomer formed from the repetitive linking of the C-terminal glycine of one UBIQUITIN molecule via an isopeptide bond to a lysine residue on a second ubiquitin molecule. It is structurally distinct from UBIQUITIN C, which is a single protein containing a tandemly arrayed ubiquitin peptide sequence.
| Descriptor ID |
D025821
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| MeSH Number(s) |
D12.776.947.500.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polyubiquitin".
Below are MeSH descriptors whose meaning is more specific than "Polyubiquitin".
This graph shows the total number of publications written about "Polyubiquitin" by people in this website by year, and whether "Polyubiquitin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2014 | 0 | 2 | 2 |
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Below are the most recent publications written about "Polyubiquitin" by people in Profiles.
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Nawarathnage S, Tseng YJ, Soleimani S, Smith T, Pedroza Romo MJ, Abiodun WO, Egbert CM, Madhusanka D, Bunn D, Woods B, Tsubaki E, Stewart C, Brown S, Doukov T, Andersen JL, Moody JD. Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1?UBA domain. Structure. 2023 12 07; 31(12):1589-1603.e6.
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Bester SM, Daczkowski CM, Faaberg KS, Pegan SD. Insights into the Porcine Reproductive and Respiratory Syndrome Virus Viral Ovarian Tumor Domain Protease Specificity for Ubiquitin and Interferon Stimulated Gene Product 15. ACS Infect Dis. 2018 09 14; 4(9):1316-1326.
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Xu C, He X, Zheng Z, Zhang Z, Wei C, Guan K, Hou L, Zhang B, Zhu L, Cao Y, Zhang Y, Cao Y, Ma S, Wang P, Zhang P, Xu Q, Ling Y, Yang X, Zhong H. Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response. J Virol. 2014 Oct; 88(19):11356-68.
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Jacobson AD, MacFadden A, Wu Z, Peng J, Liu CW. Autoregulation of the 26S proteasome by in situ ubiquitination. Mol Biol Cell. 2014 Jun 15; 25(12):1824-35.
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Thein S, Tao-Cheng JH, Li Y, Bayer KU, Reese TS, Dosemeci A. CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. PLoS One. 2014; 9(3):e91312.
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van Rijt SH, Keller IE, John G, Kohse K, Yildirim A?, Eickelberg O, Meiners S. Acute cigarette smoke exposure impairs proteasome function in the lung. Am J Physiol Lung Cell Mol Physiol. 2012 Nov 01; 303(9):L814-23.
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Zhang NY, Jacobson AD, Macfadden A, Liu CW. Ubiquitin chain trimming recycles the substrate binding sites of the 26 S proteasome and promotes degradation of lysine 48-linked polyubiquitin conjugates. J Biol Chem. 2011 Jul 22; 286(29):25540-6.
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Zhou X, Shapiro L, Fellingham G, Willardson BM, Burton GF. HIV replication in CD4+ T lymphocytes in the presence and absence of follicular dendritic cells: inhibition of replication mediated by a-1-antitrypsin through altered I?Ba ubiquitination. J Immunol. 2011 Mar 01; 186(5):3148-55.
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Zhao M, Zhang NY, Zurawel A, Hansen KC, Liu CW. Degradation of some polyubiquitinated proteins requires an intrinsic proteasomal binding element in the substrates. J Biol Chem. 2010 Feb 12; 285(7):4771-80.
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McNatt MW, McKittrick I, West M, Odorizzi G. Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway. Mol Biol Cell. 2007 Feb; 18(2):697-706.
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